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Dimethyl phosphite

Dimethyl phosphite
Dimethyl phosphite structure
Chemical Name:
Dimethyl phosphite
(CH3O)2PHO;NCI-C54773;Dimethylfosfit;Dimethylfosfonat;Dimethylphosphit;DIMETHYL PHOSPHITE;Dimethyl phosphonat;DIMETHYL PHOSPHONATE;dimethylacidphosphite;Dimethylphosphite,98+%
Molecular Formula:
Formula Weight:
MOL File:

Dimethyl phosphite Properties

Boiling point:
170-171 °C(lit.)
1.2 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.402(lit.)
Flash point:
71 °C
Colorless liquid with a mild odor
Water Solubility 
Soluble in water.
Moisture Sensitive
Stable. Moisture sensitive. Incompatible with water, strong oxidizing agents, acid chlorides, strong bases.
CAS DataBase Reference
868-85-9(CAS DataBase Reference)
3 (Vol. 48, 71) 1999
NIST Chemistry Reference
Phosphonic acid, dimethyl ester(868-85-9)
EPA Substance Registry System
Dimethyl phosphite (868-85-9)
  • Risk and Safety Statements
Signal word  Warning
Hazard statements  H227-H303-H311-H315-H319-H335-H317-H341-H351-H412
Precautionary statements  P273-P280-P201-P210e-P261-P305+P351+P338-P405-P501a
Hazard Codes  Xn
Risk Statements  21-36-10-68-52/53-43-40
Safety Statements  26-36/37-61
RIDADR  UN 3278 6.1/PG 3
WGK Germany  1
RTECS  SZ7710000
HazardClass  3.2
PackingGroup  III
HS Code  29209013
NFPA 704
2 0

Dimethyl phosphite price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich D178454 Dimethyl phosphite 98% 868-85-9 25g $42.1 2021-03-22 Buy
Sigma-Aldrich D178454 Dimethyl phosphite 98% 868-85-9 500g $61.1 2021-03-22 Buy

Dimethyl phosphite Chemical Properties,Uses,Production

Chemical Properties

colourless liquid


  1. Dimethyl Phosphite(DMP)is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
  2. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.
  3. Dimethyl Phosphite is a degradation product of the pesticides trichlorphon and malathion and may be released into the envionment following their application. It is a contaminant (approxiately 2%) in the chemical intermediate triethyl phosphite, which hydrolyses readily to dimethyl hydrogen phosphite in the presence of moist air or water.
  4. Dimethyl Phosphite is used as a flame retardant on Nylon 6 fibres  and, in combination with guanidine and formaldehyde, to impart flame and crease resistance to cotton textiles. The compound is also used to increase fire resistance to cellulosic textiles, acrolein-grafted polyamide fibres and y-irdiated polyethylene.
  5. lt is used as a lubricant additive, as a chemical intermediate in the production of organophosphorous pesticides and as an adhesive.
  6. Dimethyl Phosphite has also been used as a stabilizer in oil and plaster and, in combination with pyroctechol, as a corrosion inhibitor on steel.


As a flame retardant on Nylon 6 fibers; intermediate in the production of pesticides and herbicides; as a stabilizer in oil and plaster; an additive to lubricants


DMP is a basic chemical which is used industrially as an intermediate. Because of its reactivity
DMP participates in a large number of chemical reactions: Due to these properties DMP is used as an intermediate for the manufacturing of

Synthesis Reference(s)

Canadian Journal of Chemistry, 34, p. 1819, 1956 DOI: 10.1139/v56-235

Health Hazard

Dimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice.
An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice.
Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available.
Proposed metabolic pathways of DMP in rats and mice
Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997).

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POx


Dimethyl hydrogen phosphite was not mutagenic to several strains of Salmonella typhimurium, but it did cause sister chromatid exchanges and chromosomal aberrations in the Chinese hamster CHO line.
An ACGIH threshold limit value (TLV) has not been established for dimethyl hydrogen phosphite.

Dimethyl phosphite Preparation Products And Raw materials

Raw materials

Preparation Products

Dimethyl phosphite Suppliers

Global( 216)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886 China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693 CHINA 22607 55
career henan chemical co
+86-371-86658258 CHINA 29961 58
Hubei Jusheng Technology Co.,Ltd.
027-59599243 CHINA 28229 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114 CHINA 6369 58
Hubei xin bonus chemical co. LTD
027-59338440 CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873 CHINA 37282 58
86-18523575427 CHINA 47496 58
Hebei Yirun Sega Biological Technology Co. Ltd
19932103556 +8619932103556
+8619932103556 CHINA 727 58
ShenZhen Ipure Biology import and export company co.,ltd
18071025641 18071025641 CHINA 11336 58

View Lastest Price from Dimethyl phosphite manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-15 Dimethyl phosphite
US $13.00 / ml 100ml 99% 500ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-10-14 Dimethyl phosphite
US $1.20 / ml 100ml 99% 5ton/Month Hebei Yirun Sega Biological Technology Co. Ltd
2021-08-26 Dimethyl phosphite
US $9.10 / KG 1KG 99% 10 ton Hebei Crovell Biotech Co Ltd

Dimethyl phosphite Spectrum

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