다이메틸 히드로겐 포스피트
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다이메틸 히드로겐 포스피트 속성
- 끓는 점
- 170-171 °C(lit.)
- 밀도
- 1.2 g/mL at 25 °C(lit.)
- 굴절률
- n
20/D 1.402(lit.)
- 인화점
- 71 °C
- 용해도
- 클로로포름(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- Colorless liquid with a mild odor
- 수용성
- 물에 용해됩니다.
- 감도
- Moisture Sensitive
- BRN
- 1697490
- 안정성
- 안정적인. 수분에 민감합니다. 물, 강산화제, 산염화물, 강염기와 혼합할 수 없습니다.
- CAS 데이터베이스
- 868-85-9(CAS DataBase Reference)
- IARC
- 3 (Vol. 48, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 21-36-10-68-52/53-43-40 | ||
안전지침서 | 26-36/37-61 | ||
유엔번호(UN No.) | UN 3278 6.1/PG 3 | ||
WGK 독일 | 1 | ||
RTECS 번호 | SZ7710000 | ||
TSCA | Yes | ||
위험 등급 | 3.2 | ||
포장분류 | III | ||
HS 번호 | 29209013 | ||
유해 물질 데이터 | 868-85-9(Hazardous Substances Data) | ||
기존화학 물질 | KE-28494 |
다이메틸 히드로겐 포스피트 C화학적 특성, 용도, 생산
화학적 성질
colourless liquid용도
- Dimethyl Phosphite(DMP)is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
- It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.
- Dimethyl Phosphite is a degradation product of the pesticides trichlorphon and malathion and may be released into the envionment following their application. It is a contaminant (approxiately 2%) in the chemical intermediate triethyl phosphite, which hydrolyses readily to dimethyl hydrogen phosphite in the presence of moist air or water.
- Dimethyl Phosphite is used as a flame retardant on Nylon 6 fibres and, in combination with guanidine and formaldehyde, to impart flame and crease resistance to cotton textiles. The compound is also used to increase fire resistance to cellulosic textiles, acrolein-grafted polyamide fibres and y-irdiated polyethylene.
- lt is used as a lubricant additive, as a chemical intermediate in the production of organophosphorous pesticides and as an adhesive.
- Dimethyl Phosphite has also been used as a stabilizer in oil and plaster and, in combination with pyroctechol, as a corrosion inhibitor on steel.
주요 응용
DMP is a basic chemical which is used industrially as an intermediate. Because of its reactivityDMP participates in a large number of chemical reactions:
- Addition to oxo compounds
- Addition to oxo compounds with subsequent condensation e.g. with amines
- Oxidation with oxygen or chlorine
- Addition to alkenes
- water treatment chemicals e.g. corrosion inhibitors for cooling-water circuits (about 50 %)
- pesticides and pharmaceuticals (about 20 %)
- flame retardants and other specialities (about 15 %)
- textile finishing products (about 15 %)
건강위험
Dimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice.An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice.
Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available.
Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997).
Safety Profile
Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POxCarcinogenicity
Dimethyl hydrogen phosphite was not mutagenic to several strains of Salmonella typhimurium, but it did cause sister chromatid exchanges and chromosomal aberrations in the Chinese hamster CHO line.An ACGIH threshold limit value (TLV) has not been established for dimethyl hydrogen phosphite.
다이메틸 히드로겐 포스피트 준비 용품 및 원자재
원자재
준비 용품
DIMETHYL PHOSPHOROCHLORIDATE
2-포스포노-1,2,4-부탄트리카복실산
ammonium O,O-dimethyl thiophosphate
Phosphite
Azamethiphos
오메토산
트리클로르폰
글리포세이트
페닐포스폰산디메틸
DIMETHYL-P-NITROPHENYLPHOSPHATE
Dibenzoic thioanhydride
sodium O,O-dimethyl thiophosphate
DIISOBUTYL PHOSPHITE
4-Bromophenyl methyl sulfone
3-oxo-1,3-dihydroisobenzofuran-1-ylphosphonic acid
다이메틸 히드로겐 포스피트 공급 업체
글로벌( 300)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 951 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |