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다이메틸 히드로겐 포스피트

다이메틸 히드로겐 포스피트
다이메틸 히드로겐 포스피트 구조식 이미지
카스 번호:
다이메틸 히드로겐 포스피트
다이메틸히드로겐포스피트;다이메틸히드로겐포스피트(DIMETHYLHYDROGENPHOSPHITE);다이메틸 하이드로겐 포스파이트;DMHP;다이메틸 무기인 산;다이메틸 포스포네이트;다이메틸 포스피트;다이메틸 하이드로겐 포스피트;다이메틸하이드로겐 포스피트;무기인 산 다이메틸 에스터;포스폰 산, 다이메틸 에스터;하이드로겐 다이메틸 포스피트
Dimethyl phosphite
(CH3O)2PHO;NCI-C54773;Dimethylfosfit;Dimethylfosfonat;Dimethylphosphit;DIMETHYL PHOSPHITE;Dimethyl phosphonat;DIMETHYL PHOSPHONATE;dimethylacidphosphite;Dimethylphosphite,98+%
포뮬러 무게:
MOL 파일:

다이메틸 히드로겐 포스피트 속성

끓는 점
170-171 °C(lit.)
1.2 g/mL at 25 °C(lit.)
n20/D 1.402(lit.)
71 °C
물리적 상태
Colorless liquid with a mild odor
Soluble in water.
Moisture Sensitive
Stable. Moisture sensitive. Incompatible with water, strong oxidizing agents, acid chlorides, strong bases.
CAS 데이터베이스
868-85-9(CAS DataBase Reference)
Phosphonic acid, dimethyl ester(868-85-9)
3 (Vol. 48, 71) 1999
Dimethyl phosphite (868-85-9)
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 21-36-10-68-52/53-43-40
안전지침서 26-36/37-61
유엔번호(UN No.) UN 3278 6.1/PG 3
WGK 독일 1
RTECS 번호 SZ7710000
위험 등급 3.2
포장분류 III
HS 번호 29209013
유해 물질 데이터 868-85-9(Hazardous Substances Data)
기존화학 물질 KE-28494
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H303 삼키면 유해할 수 있음 급성 독성 물질 - 경구 구분 5 P312
H311 피부와 접촉하면 유독함 급성 독성 물질 - 경피 구분 3 위험 P280, P302+P352, P312, P322, P361,P363, P405, P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H412 장기적 영향에 의해 수생생물에 유해함 수생 환경유해성 물질 - 만성 구분 3 P273, P501
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.
NFPA 704
2 0

다이메틸 히드로겐 포스피트 MSDS

Dimethyl phosphite

다이메틸 히드로겐 포스피트 C화학적 특성, 용도, 생산

화학적 성질

colourless liquid


  1. Dimethyl Phosphite(DMP)is used as a reagent in the synthesis of 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors.
  2. It is also used as a reagent in the synthesis of estafiatin phosphonate derivatives which exhibit antibacterial and antifungal activity.
  3. Dimethyl Phosphite is a degradation product of the pesticides trichlorphon and malathion and may be released into the envionment following their application. It is a contaminant (approxiately 2%) in the chemical intermediate triethyl phosphite, which hydrolyses readily to dimethyl hydrogen phosphite in the presence of moist air or water.
  4. Dimethyl Phosphite is used as a flame retardant on Nylon 6 fibres  and, in combination with guanidine and formaldehyde, to impart flame and crease resistance to cotton textiles. The compound is also used to increase fire resistance to cellulosic textiles, acrolein-grafted polyamide fibres and y-irdiated polyethylene.
  5. lt is used as a lubricant additive, as a chemical intermediate in the production of organophosphorous pesticides and as an adhesive.
  6. Dimethyl Phosphite has also been used as a stabilizer in oil and plaster and, in combination with pyroctechol, as a corrosion inhibitor on steel.


As a flame retardant on Nylon 6 fibers; intermediate in the production of pesticides and herbicides; as a stabilizer in oil and plaster; an additive to lubricants

주요 응용

DMP is a basic chemical which is used industrially as an intermediate. Because of its reactivity
DMP participates in a large number of chemical reactions: Due to these properties DMP is used as an intermediate for the manufacturing of

Synthesis Reference(s)

Canadian Journal of Chemistry, 34, p. 1819, 1956 DOI: 10.1139/v56-235


Dimethyl Phosphite (DMP) is rapidly absorbed via the oral and dermal routes. The main metabolic pathway in rodents is demethylation to monomethyl hydrogen phosphite (MMP) and further oxidation to CO2. DMP was mainly eliminated via urine and expired air. Over the studied dose range between 10 and 200 mg/kg bw and 5 x 200 mg/kg bw, respectively, only little evidence of bioaccumulation or saturation of absorption and elimination was observed. The only difference in studied toxicokinetics between rats and mice was the more rapid metabolism and elimination in mice.
An inhalation LC50 value is not available, but an exposure of 7100 mg/m³ (concentration estimated based on air flow and net loss of material) over 6 hours was not lethal for rats, mice and guinea pigs. Clinical signs were observed in mice only, and included occasionally laboured respiration after approximately 2 hours of exposure and ptosis after 5 hours. The acute dermal LD50 was 681 mg/kg bw (rabbits). Signs of intoxication were depression, ptosis, labored respiration, ataxia and placidity. The acute oral LD50 values were: 3283 mg/kg bw for male rats, 3040 mg/kg bw for female rats, 2815 mg/kg bw for male mice, and between 2150 and 3160 mg/kg bw for female mice. Clinical signs were inactivity, weakness, prostration and shallow breathing at doses near to or exceeding the LD50 values. White opaque eyes were seen in male mice.
Dimethyl Phosphite is irritating to the skin and eyes of rabbits. After prolonged or repeated exposures moderate to severe irritation of skin and mucosa was observed in rats. No sensitisation studies are available.
Proposed metabolic pathways of DMP in rats and mice
Proposed metabolic pathways of DMP in rats and mice (Nomeir and Matthews, 1997).

Safety Profile

Suspected carcinogen with experimental carcinogenic data. Moderately toxic by ingestion and skin contact. A skin and eye irritant. Mutation data reported. When heated to decomposition it emits toxic fumes of POx


Dimethyl hydrogen phosphite was not mutagenic to several strains of Salmonella typhimurium, but it did cause sister chromatid exchanges and chromosomal aberrations in the Chinese hamster CHO line.
An ACGIH threshold limit value (TLV) has not been established for dimethyl hydrogen phosphite.

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