Acetazolamide
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Acetazolamide 속성
- 녹는점
- 258-259 °C
- 밀도
- 1.610 (estimate)
- 굴절률
- 1.6270 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- NH4OH(50mg/mL), DMSO, 메탄올에 용해되고 에탄올에는 약간 용해됩니다.
- 산도 계수 (pKa)
- 7.2(at 25℃)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 흰색에서 황백색까지
- 수용성
- 22&C에서 <0.1g/100mL
- 최대 파장(λmax)
- 265nm(H2O)(lit.)
- Merck
- 14,53
- BRN
- 212994
- BCS Class
- 4
- 안정성
- 흡습성
- InChIKey
- BZKPWHYZMXOIDC-UHFFFAOYSA-N
- CAS 데이터베이스
- 59-66-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38-36/37/38 | ||
| 안전지침서 | 26-36 | ||
| 유엔번호(UN No.) | 2811 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | AC8225000 | ||
| TSCA | Yes | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | III | ||
| HS 번호 | 29350090 | ||
| 유해 물질 데이터 | 59-66-5(Hazardous Substances Data) | ||
| 독성 | LD50 oral in mouse: 4300mg/kg |
Acetazolamide C화학적 특성, 용도, 생산
개요
Acetazolamide is a weak diuretic with limited use in edema associated with cardiac insufficiency, glaucoma, minor epileptic attacks, and altitude sickness.화학적 성질
White Solid용도
Acetazolamide is used for epilepsy in the absence of attacks and also in conjunction with other antiepileptic drugs.일반 설명
White to yellowish-white fine crystalline powder. No odor or taste.공기와 물의 반응
Insoluble in water.반응 프로필
A weak acid and a diazo derivative. Azo, diazo, azido compounds can detonate. This applies in particular to organic azides that have been sensitized by the addition of metal salts or strong acids. Toxic gases are formed by mixing materials of this class with acids, aldehydes, amides, carbamates, cyanides, inorganic fluorides, halogenated organics, isocyanates, ketones, metals, nitrides, peroxides, phenols, epoxides, acyl halides, and strong oxidizing or reducing agents. Flammable gases are formed by mixing materials in this group with alkali metals. Explosive combination can occur with strong oxidizing agents, metal salts, peroxides, and sulfides.화재위험
Flash point data for Acetazolamide are not available; however, Acetazolamide is probably combustible.Mechanism of action
Acetazolamide is an aromatic sulfonamide used as a carbonic anhydrase inhibitor. It facilitates production of alkaline urine with an elevated biocarbonate, sodium, and potassium ion concentrations. By inhibiting carbonic anhydrase, the drug suppresses reabsorption of sodium ions in exchange for hydrogen ions, increases reflux of bicarbonate and sodium ions and reduces reflux of chloride ions. During this process, chloride ions are kept in the kidneys to cover of insufficiency of bicarbonate ions, and for keeping an ion balance. Electrolytic contents of fluid secreted by the kidneys in patients taking carbonic anhydrase inhibitors are characterized by elevated levels of sodium, potassium, and bicarbonate ions and a moderate increase in water level. Urine becomes basic, and the concentration of bicarbonate in the plasma is reduced.Clinical Use
Acetazolamide was the first of the carbonic anhydrase inhibitors to be introduced as an orally effective diuretic, with a diuretic effect that lasts approximately 8 to 12 hours. As mentioned earlier, its diuretic action is limited because of the systemic acidosis it produces. Acetazolamide reduces the rate of aqueous humor formation and is used primarily for reducing intraocular pressure in the treatment of glaucoma. The dose is 250 mg to 1 g per day.Safety Profile
Poison by subcutaneous and intravenous routes. Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: dyspnea. An experimental teratogen by many routes. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NOx, and SOx,. A carbonic anhydrase inhibitor and dmretic used to treat glaucoma.Purification Methods
It is recrystallised from water. [Roblin & Clapp J Am Chem Soc 72 4890 1950, Beilstein 27 III/IV 8219.]Acetazolamide 준비 용품 및 원자재
원자재
아세틸 염화물
싸이오사이안산암모늄(로단암몬)
염화설퍼릴
2-Acetylamino-5-mercapto-1,3,4-thiadiazole
산성아황산나트륨
Butanedioic acid,1-[1-[[(1-methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl] ester
Benzoic acid, 2-[[[[5-(acetylamino)-1,3,4-thiadiazol-2-yl]sulfonyl]amino]carbonyl]-, 1-[[(1-methylethyl)amino]methyl]-2-(1-naphthalenyloxy)ethyl ester
5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
2-ACETAMIDO-5-BENZYLTHIO-1 3 4-
2-(ACETAMIDO)-5-(CHLOROSULFONYL)-1,3,4-THIADIAZOLE
준비 용품
Acetazolamide 공급 업체
글로벌( 397)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 |
CHINA | 115 | 55 | |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Acetazolamide 관련 검색:
4-(아세틸아미노)벤젠설포닐 클로라이드 아세트아미노펜 5-메틸-1,3,4-티아디아졸-2-티올 설파닐아미드 에이사이클로비르
2,1,3-Benzothiadiazole
2,5-Dimethoxyacetoacetanilide
4'-Methoxyacetoacetanilide
2-CHLORO-N-1,3,4-THIADIAZOL-2-YLACETAMIDE
bis(2-Acetamido-1,3,4-thiadiazol-5-yl) Disulfide
4'-Chloro-2',5'-dimethoxyacetoacetanilide
2',4'-Dimethylacetoacetanilide
ACETAZOLAMIDE-D3
5-AMINO-1,3,4-THIADIAZOLE-2-SULFONAMIDE
5-Amino-1,3,4-thiadiazole-2-thiol
NSC 231656
2-Acetylamino-5-mercapto-1,3,4-thiadiazole
2-(AcetylaMino)-5-sulfo-1,3,4-thiadiazole