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산성아황산나트륨

	산성아황산나트륨
산성아황산나트륨 구조식 이미지
카스 번호:
7681-57-4
한글명:
산성아황산나트륨
동의어(한글):
디나트륨디아황산염;나트륨디아황산염;나트륨디아황산염(NA2S2O5);나트륨메타비아황산염(NA2S2O5);나트륨메타이아황산염;나트륨피로아황산염(NA2S2O5);나트륨피로아황산염;디나트륨메타비아황산염;디나트륨피로아황산염;디나트륨피로아황산염(NA2S2O5);디아황산디나트륨염;디아황산,디나트륨염;메타중아황산나트륨;소듐메타바이설파이트;소디움메타디설파이트;소디움메타바이설파이트;피로아황산,디나트륨염;산성아황산나트륨;소디움메타바이설파이트; 산성아황산나트륨
상품명:
Sodium metabisulfite
동의어(영문):
E223;fertisilo;Sodium disulphite;SodiuM pyrosulfit;Sodium pyrosulfite;Sodiummetabisufite;Sodium dissulfite ;Disodium disulphite;Sodium pyrosulphite;Sodiummetadisulfite
CBNumber:
CB9854280
분자식:
2Na.O5S2
포뮬러 무게:
190.11
MOL 파일:
7681-57-4.mol

산성아황산나트륨 속성

녹는점
150 °C
밀도
1.48
저장 조건
Store at RT.
용해도
540 g/L (20°C)
물리적 상태
Powder/Solid
Specific Gravity
1.48
색상
White to slightly yellow
수소이온지수(pH)
3.5-5 (50g/l, H2O, 20℃)
수용성
540 g/L (20 ºC)
감도
Air & Moisture Sensitive
Merck
14,8638
안정성
Stable. Incompatible with strong oxidizing agents, strong acids. Contact with strong acids releases a poisonous gas. May be moisture and air sensitive.
InChIKey
HRZFUMHJMZEROT-UHFFFAOYSA-L
CAS 데이터베이스
7681-57-4(CAS DataBase Reference)
EPA
Disulfurous acid, disodium salt(7681-57-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-31-41-36/37/38-52
안전지침서 26-39-46-36-16
유엔번호(UN No.) 3260
WGK 독일 1
RTECS 번호 UX8225000
TSCA Yes
HS 번호 2832 10 00
포장분류 III
유해 물질 데이터 7681-57-4(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 1540 mg/kg LD50 dermal Rat > 2000 mg/kg
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

산성아황산나트륨 C화학적 특성, 용도, 생산

물성

외관:백색 결정 또는 분말.

용도

도금폐수처리, 아크릴 중합제, 식품보존제, 펄프 표백제, 사진현상제.

화학적 성질

white crystalline powder with a sulfur smell

화학적 성질

Sodium metabisulfite is a white crystalline powder. Sulfur dioxide odor. It may be considered the anhydride of 2 molecules of sodium disulfite.

화학적 성질

Sodium metabisulfite occurs as colorless, prismatic crystals or as a white to creamy-white crystalline powder that has the odor of sulfur dioxide and an acidic, saline taste. Sodium metabisulfite crystallizes from cold water as a hydrate containing seven water molecules.

용도

Sodium Metabisulfite is a preservative and antioxidant that exists as crystals or powder having a sulfur dioxide odor. it is readily solu- ble in water. it is used in dried fruits to preserve flavor, color, and to inhibit undesirable microorganism growth. it prevents “black spots” due to oxidative deterioration in shrimp. it is used in maraschino cherries. it is found in lemon drinks as a preservative. see sulfur dioxide.

용도

Pharmaceutic aid (antioxidant).

용도

sodium metabisulfite is an anti-oxidant and reducing agent.

정의

ChEBI: An inorganic sodium salt composed of sodium and disulfite ions in a 2:1 ratio.

생산 방법

Sodium metabisulfite is prepared by saturating a solution of sodium hydroxide with sulfur dioxide and allowing crystallization to occur; hydrogen is passed through the solution to exclude air. Sodium metabisulfite may also be prepared by saturating a solution of sodium carbonate with sulfur dioxide and allowing crystallization to occur, or by thermally dehydrating sodium bisulfite.

위험도

Toxic by inhalation. Upper respiratory tract irritant. Questionable carcinogen.

Pharmaceutical Applications

Sodium metabisulfite is used as an antioxidant in oral, parenteral, and topical pharmaceutical formulations, at concentrations of 0.01–1.0% w/v, and at a concentration of approximately 27% w/v in intramuscular injection preparations. Primarily, sodium metabisulfite is used in acidic preparations; for alkaline preparations, sodium sulfite is usually preferred. Sodium metabisulfite also has some antimicrobial activity, which is greatest at acid pH, and may be used as a preservative in oral preparations such as syrups.
In the food industry and in wine production, sodium metabisulfite is similarly used as an antioxidant, antimicrobial preservative, and antibrowning agent. However, at concentrations above about 550 ppm it imparts a noticeable flavor to preparations. Sodium metabisulfite usually contains small amounts of sodium sulfite and sodium sulfate.

색상 색인 번호

This agent is frequently used as a preservative in pharmaceutical products, in the bread-making industry as an antioxidant, and it can induce contact dermatitis. It can be used as a reducing agent in photography and caused dermatitis in a photographic technician, probably acting as an aggravating irritative factor. Sodium metabisulfite contains a certain amount of sodium sulfite and sodium sulfate.

Safety Profile

An inhalation hazard. Poison by intravenous route. Moderately toxic by parenteral route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of SOx and Na2O.

Safety

Sodium metabisulfite is widely used as an antioxidant in oral, topical, and parenteral pharmaceutical formulations; it is also widely used in food products.
Although it is extensively used in a variety of preparations, sodium metabisulfite and other sulfites have been associated with a number of severe to fatal adverse reactions. These are usually hypersensitivity-type reactions and include bronchospasm and anaphylaxis. Allergy to sulfite antioxidants is estimated to occur in 5–10% of asthmatics, although adverse reactions may also occur in nonasthmatics with no history of allergy.
Following oral ingestion, sodium metabisulfite is oxidized to sulfate and is excreted in urine. Ingestion may result in gastric irritation, owing to the liberation of sulfurous acid, while ingestion of large amounts of sodium metabisulfite can cause colic, diarrhea, circulatory disturbances, CNS depression, and death.
In Europe, the acceptable daily intake of sodium metabisulfite and other sulfites used in foodstuffs has been set at up to 3.5 mg/kg body-weight, calculated as sulfur dioxide (SO2). The WHO has similarly also set an acceptable daily intake of sodium metabisulfite, and other sulfites, at up to 7.0 mg/kg body-weight, calculated as sulfur dioxide (SO2).
LD50 (rat, IV): 0.12 g/kg

잠재적 노출

Sodium metabisulfite is used as an antioxidant in pharmaceutical preparations and as a preservative in foods. People with asthma have a greater chance of having an allergic reaction with this chemical. Individuals allergic to sodium bisulfite (a food preservative found in some wine, fresh shrimp; packaged foods; and restaurant salads and potatoes) may have a severe reaction when exposed to sodium metabisulfite.

저장

On exposure to air and moisture, sodium metabisulfite is slowly oxidized to sodium sulfate with disintegration of the crystals. Addition of strong acids to the solid liberates sulfur dioxide.
In water, sodium metabisulfite is immediately converted to sodium (Na+) and bisulfite (HSO3-) ions. Aqueous sodium metabisulfite solutions also decompose in air, especially on heating. Solutions that are to be sterilized by autoclaving should be filled into containers in which the air has been replaced with an inert gas, such as nitrogen. The addition of dextrose to aqueous sodium metabisulfite solutions results in a decrease in the stability of the metabisulfite.
The bulk material should be stored in a well-closed container, protected from light, in a cool, dry place.

운송 방법

UN1759 Corrosive solids, n.o.s., Hazard class: 8; Labels: 8-Corrosive material, Technical Name required. UN2693 Bisulfites, inorganic, aqueous solutions, n.o.s., Hazard class: 8; Labels: 8-Corrosive material.

비 호환성

Sodium metabisulfite reacts with sympathomimetics and other drugs that are ortho- or para-hydroxybenzyl alcohol derivatives to form sulfonic acid derivatives possessing little or no pharmacological activity. The most important drugs subject to this inactivation are epinephrine (adrenaline) and its derivatives. In addition, sodium metabisulfite is incompatible with chloramphenicol owing to a more complex reaction; it also inactivates cisplatin in solution.
It is incompatible with phenylmercuric acetate when autoclaved in eye drop preparations.
Sodium metabisulfite may react with the rubber caps of multidose vials, which should therefore be pretreated with sodium metabisulfite solution.

비 호환성

A strong reducing agent. Keep away from oxidizers. Mixtures with water forms a strong corrosive. Contact with acids releases toxic fumes. Heat causes decomposition. Slowly oxidized to the sulfate on exposure to air and moisture. Attacks metals

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (epidural;inhalation; IM and IV injections; ophthalmic solutions; oral preparations; rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

산성아황산나트륨 준비 용품 및 원자재

원자재

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