노르에티스테론
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노르에티스테론 속성
- 녹는점
- 205-206 °C (lit.)
- 알파
- D20 -31.7° (chloroform); D20 -25° (chloroform)
- 끓는 점
- 379.83°C (rough estimate)
- 밀도
- 1.0766 (rough estimate)
- 굴절률
- 1.4800 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름: 50mg/mL, 투명, 무색
- 산도 계수 (pKa)
- 13.09±0.40(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수용성
- 7.043mg/L(25 ºC)
- Merck
- 6697
- BRN
- 1915671
- BCS Class
- 1
- InChIKey
- VIKNJXKGJWUCNN-XGXHKTLJSA-N
- CAS 데이터베이스
- 68-22-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 40-36/37/38-20/21/22 | ||
안전지침서 | 22-36/37/39-45-37/39-26 | ||
유엔번호(UN No.) | UN 3077 9 / PGIII | ||
WGK 독일 | 3 | ||
RTECS 번호 | RC8975000 | ||
HS 번호 | 29144000 | ||
유해 물질 데이터 | 68-22-4(Hazardous Substances Data) | ||
독성 | LD50 oral in mouse: 6gm/kg | ||
기존화학 물질 | KE-20746 |
노르에티스테론 C화학적 특성, 용도, 생산
개요
Norethindrone is a progestin (a synthetic substance with properties similar to progesterone) that is best known as the first female oral contraceptive, or the “pill.”Norethindrone’s global impact on society and culture has made it one of the most important inventions in history.화학적 성질
Off-White to Pale Yellow Solid역사
The development of norethindrone as a female oral contraceptive took place indirectly over 30 years as a result of steroid research.This research accelerated in the 1930s when structures and medical applications of steroidal compounds were determined.Steroids are lipids, which include cholesterol, bile salts,and sex hormones,that are characterized by a structure of three fused six-carbon rings and a five-carbon ring.In 1957, both norethindrone and norethynodrel were approved by the Food and Drug Administration (FDA) for treating menstrual problems and infertility. In 1960, the FDA approved Searle's norethynodrel under the trade name Enovid. Norethindrone was approved as an oral contraceptive in 1962 under the trade name Ortho-Novum.
용도
Progesteron. Norethindrone and acetate in combination with estrogen as contraceptive (oral). It is reasonably anticipated to be a human carcinogen정의
ChEBI: A 17beta-hydroxy steroid that is testosterone in which the hydrogen at position 17 is replaced by an ethynyl group and in which the methyl group attached to position 10 is replaced by hydrogen.부작용
Some of the more common side effects of Norethindrone include breast tenderness, hair growth, especially on the face; pimples, weight gain, frequent and irregular bleeding; and menstrual changes. Possible side effects may include: blindness, blue-yellow colour blindness, breast pain, tightness in the chest, chills, clay-coloured stools, cough, dark-coloured urine, diarrhoea, difficulty swallowing, headache and dizziness, eye pain, fast heartbeat, feeling sad or empty, fever, general tiredness and weakness, heavy non-menstrual vaginal bleeding, hives, itching or rash, loss of appetite, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue Swelling; Stomach ache, etc.Safety Profile
Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Mddly toxic by ingestion. Human systemic effects by ingestion: dermatitis and androgenic effects. Human teratogenic effects: developmental abnormalities of the musculoskeletal system and urogenital system; and behavioral effects in the newborn. Human reproductive effects: spermatogenesis; testes, epididymis, sperm duct changes; impotence; male breast development; other male effects; ovaries, fallopian tube changes; menstrual cycle effects; postpartum effects; changes in female fertility. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.Carcinogenicity
Norethisterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.노르에티스테론 준비 용품 및 원자재
원자재
테트라하이드로푸란
암모니아(가스)
Lithium
칼륨
아세틸렌
삼산화크롬무수물
오소포름산에틸
Estrone 3-methyl ether
Norandrostenedione
19-ALDOANDROSTENEDIONE
3-에톡시에스트라-3,5-디엔-17-온
3-메톡시에스트라-2,5(10)-디엔-17베타-올
19-Norpregna-2,5(10)-dien-20-yn-17-ol, 3-methoxy-, (17α)- (9CI)
19-HYDROXY-4-ANDROSTENE-3,17-DIONE
19-CARBOXYANDROST-4-ENE-3,17-DIONE
Norethindrone-3-ethyldienolether
난드롤론
준비 용품
노르에티스테론 공급 업체
글로벌( 484)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Henan Tengmao Chemical Technology Co. LTD | +8615238638457 |
salesvip2@hntmhg.com | China | 415 | 58 |
Wuhan Haorong Biotechnology Co.,ltd | +8618565342920 |
sales@chembj.net | China | 269 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 |
admin@guyunchem.com | China | 616 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
Nanjing Finetech Chemical Co., Ltd. | 025-85710122 17714198479 |
sales@fine-chemtech.com | CHINA | 885 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
노르에티스테론 관련 검색:
레보노게스트렐 메드록시프로게스테론 아세트산 에티스테론 프로게스테론 노르에틴드론 아세트산 노르에티스테론
Premarin
CHLOROPHOSPHONAZO III
Norgestrel
(17α)-13-Ethyl-3-methoxy-18,19-dinorpregna-3,5-dien-20-yn-17-ol
5(6)-Dehydro-4(5)-dihydro D-(-)-Norgestrel
6-Oxo D-(-)-Norgestrel
(±)-13-ethyl-3-methoxygona-2,5(10)-dien-17beta-ol
18-Methyl Mestranol
13-ethyl-3-methoxy-18,19-dinor-17alpha-pregna-2,5(10)-dien-20-yn-17-ol
6β-Hydroxy Norgestrel
Levonorgestrel EP Impurity I
13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one