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프로게스테론

프로게스테론
프로게스테론 구조식 이미지
카스 번호:
57-83-0
한글명:
프로게스테론
동의어(한글):
프로게스테론;루테인
상품명:
Progesterone
동의어(영문):
CIDR;Lutex;Lutin;U 3672;Lutein;Luteol;Luteum;lutren;Prolets;Luteine
CBNumber:
CB4224484
분자식:
C21H30O2
포뮬러 무게:
314.46
MOL 파일:
57-83-0.mol

프로게스테론 속성

녹는점
128-132 °C(lit.)
알파
186 º (c=1, ethanol)
끓는 점
394.13°C (rough estimate)
밀도
d23 1.166; d20 1.171
굴절률
182 ° (C=2, Dioxane)
인화점
2℃
저장 조건
Store at RT
용해도
H2O: 25 mg/mL, may be clear to slightly hazy
물리적 상태
powder
색상
Yellow to yellow-brown
수용성
<0.1 g/100 mL at 19 ºC
Merck
7773
BRN
1915950
안정성
Stable. Incompatible with strong oxidizing agents.
InChIKey
RJKFOVLPORLFTN-LEKSSAKUSA-N
CAS 데이터베이스
57-83-0(CAS DataBase Reference)
NIST
Progesterone(57-83-0)
EPA
Pregn-4-ene-3,20- dione(57-83-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,T,F
위험 카페고리 넘버 40-45-62-36-20/21/22-11
안전지침서 36/37-45-53-16
유엔번호(UN No.) UN 1648 3 / PGII
WGK 독일 3
RTECS 번호 TW0175000
HS 번호 29372390
유해 물질 데이터 57-83-0(Hazardous Substances Data)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P370+P378 화재 시 불을 끄기 위해 (Section 5. 폭발, 화재시 대처방법의 적절한 소화제)을(를) 사용하시오.
P403+P235 환기가 잘 되는 곳에 보관하고 저온으로 유지하시오.

프로게스테론 MSDS


4-Pregnene-3,20-dione

프로게스테론 C화학적 특성, 용도, 생산

화학적 성질

White powder. Melting point 121°C. Stable in air. Insoluble in water. A female sex hormone. Low toxicity.

출처

Colchicum luteum also yields this alkaloid.

용도

Sterid hormone produced by the corpus luteum. Induces maturation and secretory activity of the uterine endothelium; suppresses ovulation. Progesterone is implicated in the etiology of breast cancer

정의

progesterone: hormone, producedprimarily by the corpus luteumof the ovary but also by theplacenta, that prepares the inner liningof the uterus for implantation ofa fertilized egg cell. If implantationfails, the corpus luteum degeneratesand progesterone production ceasesaccordingly. If implantation occurs,the corpus luteum continues to secreteprogesterone, under the influenceof luteinizing hormone andprolactin, for several months of pregnancy,by which time the placentahas taken over this function. Duringpregnancy, progesterone maintainsthe constitution of the uterus andprevents further release of eggs fromthe ovary. Small amounts of progesteroneare produced by the testes.

정의

ChEBI: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and ot er species.

상표명

Crinone (Columbia); Prometrium (Unimed).

일반 설명

Progesterone, pregn-4-en-3,20-dione, is so rapidly metabolized that it is not particularlyeffective orally, being only one twelfth as active as intramuscularly.An oral formulation of micronized progesterone(Prometrium) is available. Progesterone given intramuscularlycan be very irritating. A vaginal gel containing 4% or8% progesterone offers an alternative dosage form.Progesterone was originally obtained from animal ovariesbut is now prepared synthetically from plant sterol precursors.The discovery of 19-nortestosterones with progesteroneactivity made synthetically modified progestins of tremendoustherapeutic importance.
Progesterone (and all other steroid 4-ene-3-ones) is lightsensitive and should be protected from light.

공기와 물의 반응

Insoluble in water.

반응 프로필

Progesterone is sensitive to light .

위험도

A carcinogen (OSHA).

건강위험

ACUTE/CHRONIC HAZARDS: Progesterone may be absorbed through the skin.

화재위험

Flash point data for Progesterone are not available; however, Progesterone is probably combustible.

생물학적 활성

Endogenous progesterone receptor (PR) agonist (EC 50 = 0.5 nM).

Safety Profile

NTP 10th Report on Carcinogens. IARC Cancer Review: Animal Lirmted Evidence IMEMDT 21,491,79; Animal Sufficient Evidence IMEMDT 6,135,74. EPA Genetic Toxicology Program. Reported in EPA TSCA Inventory. SAFETY PROFILE: Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by intravenous and intraperitoneal routes. Human teratogenic effects by ingestion and parenteral routes: developmental abnormalities of the urogenital system. Human male reproductive effects by intramuscular route: changes in spermatogenesis, the prostate, seminal vesicle, Cowper's gland and accessory glands, impotence, and breast development. Human female reproductive effects by ingestion, parenteral, and intravaginal routes: ferthty changes; menstrual cycle changes and disorders; uterus, cervix, and vagina changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

Carcinogenicity

Progesterone is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Purification Methods

The form crystallises from EtOH with m 127-131o. The -form crystallises from pet ether or aqueous pet ether/aqueous Et2O with m 119-120o or 121o. It also crystallises from Et2O, Me2CO/EtOAc, MeOH, aqueous Et2O, aqueous MeOH, wet pet ether, Et2O/pet ether, pet ether/*C6H6, Et2O/pentane and isopropyl ether. The is at 240nm with log 4.25 (EtOH). [Wintersteiner & Allen J Biol Chem 107 max 321 1934, Beilstein 7 III 3648, 7 IV 2395.]

법규

Consumer Product Safety Commission (CPSC)
Any orally administered prescription drug for human use requires child-resistant packaging.
Food and Drug Administration (FDA)
Progesterone is a prescription drug subject to labeling and other requirements.
Maximum levels of progesterone in edible animal tissues are prescribed in 21 CFR 556.540.
Progesterone in topically applied hormone-containing drugs for over the counter use is no longer considered generally recognized as safe and effective.

프로게스테론 준비 용품 및 원자재

원자재

준비 용품


프로게스테론 공급 업체

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