오소포름산에틸 C화학적 특성, 용도, 생산
화학적 성질
Colorless liquid; pungent odor. Highly flammable. Slightly soluble in water; soluble in alcohol,
ether; decomposes in water.
용도
Triethyl orthoformate is used in Bodroux-Chichibabin aldehyde synthesis to prepare an aldehyde with one carbon higher by reacting with Grignard reagent. It is also used in the electrophilic formylation of activated aromatic species such as phenol.
주요 응용
Sweet, somewhat camphoraceous-herbaceous odor with a Fimecdle-like note.
Triethyl orthoformate has been suggested for use in industrial
fragrances for masking, etc. and may find
some application in that field. It tends to lift
the odor of the conventional components of a
pine fragrance and increase the radiation, an
effect often desirable for masking purposes.
일반 설명
A clear, colorless liquid with a pungent odor. Less dense than water. Flash point 86°F. Vapors heavier than air. May irritate skin and eyes. Used to make other chemicals.
반응 프로필
Triethyl orthoformate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
위험도
Flammable, moderate fire risk.
건강위험
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
화재위험
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Safety Profile
Moderately toxic by
ingestion. Mddly toxic by inhalation, skin
contact, and subcutaneous routes. A skin
and eye irritant. A very dangerous fire
hazard when exposed to heat or flame; can
react vigorously with oxidzing materials. To
fight fire, use foam, CO2, dry chemical.
When heated to decomposition it emits
acrid smoke and irritating fumes. See also
ESTERS.
Purification Methods
Fractionate it first at atmospheric pressure, then in a vacuum. If impure, then shake it with aqueous 2% NaOH, dry it with solid KOH and distil it from sodium through a 20cm Vigreux column (p 11). Alternatively, wash it with H2O, dry it over anhydrous K2CO3, filter and fractionate it through a Widmer column (p 11). [Sah & Ma J Am Chem Soc 54 2964 1932, Ohme & Schmitz Justus Liebigs Ann Chem 716 207 1968, Beilstein 2 IV 25.] IRRITANT and FLAMMABLE.
오소포름산에틸 준비 용품 및 원자재
원자재
준비 용품
5-CARBETHOXYURACIL
Ethyl 2-hydroxy-4-methyl-5-pyrimidinecarboxylate
2-AMINO-6-CHLORO-3,5-DICYANOPYRIDINE
ETHYL 2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLATE
4, 6-DIHYDROXYNICOTINIC ACID ETHYL ESTER
Chloromethyltriethoxysilane
4(3H)-피리미디논,5-메틸-2-(메틸티오)-
1-클로로-4-이소시아노벤젠
3-(1,3,4-옥사디아졸-2-일)피리딘
1-CYCLOHEXYLURACIL
METHYL 5-AMINOISOXAZOLE-4-CARBOXYLATE
2,4-DIAMINOPYRIMIDINE-5-CARBOXYLIC ACID
2-AMINO-3,5-DICYANOPYRIDINE
Ethyl 4-amino-2-(ethylthio)-5-pyrimidinecarboxylate
2,4-DIAMINOPYRIMIDINE-5-CARBONITRILE
4-Methylpyrimidine
3-(2-FLUOROBENZYL)THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
에틸4-하이드록시-6-(트리플루오로메탄)퀴놀린-3-카복실레이트
4-Chloro-7-(trifluoromethyl)quinoline
3-Aminopyrazole-4-carboxylic acid
ETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE
4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBONITRILE
4,5-Dicyanoimidazole
ETHYL(Z)-2-CYANO-3-ETHOXY-2-PROPENOATE
Ethoxylated
1-Cyclohexyl-1,2,3,4-tetrahydro-2,4-dioxopyrimidine-5-carbonitrile ,97%
에틸3-(트리플루오로메틸)피라졸-4-카르복실레이트
4-AMINO-2-(ETHYLTHIO)-5-(HYDROXYMETHYL)PYRIMIDINE
에틸4-클로로-6-(트리플루오로메틸)-3-퀴놀린카복실레이트
N-FORMYLGLYCINE ETHYL ESTER
1-(4-메틸-2-(메틸티오)피리미딘-5-일)에타논
4-HYDROXY-5,7-BIS-TRIFLUOROMETHYL-QUINOLINE-3-CARBOXYLICACID에틸에스테르
2-HYDROXY-4-METHYLPYRIMIDINE-5-CARBOXYLIC ACID
4-Acetylphenylboronic acid
2-Formylfuran-5-boronic acid
Diethoxymethyl acetate
Estazolam
5-아미노-4-카르베톡시-1-페닐피라졸
2-HYDROXY-4-PHENYLPYRIMIDINE-5-CARBOXYLIC ACID
5-아미노-1-페닐피라졸-4-카보니트릴