Pomalidomide-PEG6-butyl iodide
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Pomalidomide-PEG6-butyl iodide 속성
- 끓는 점
- 853.5±65.0 °C(Predicted)
- 밀도
- 1.448±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- DMSO : 100 mg/mL (131.30 mM; Need ultrasonic)
- 산도 계수 (pKa)
- 10.68±0.40(Predicted)
- 물리적 상태
- Solid
- 색상
- White to off-white
안전
Pomalidomide-PEG6-butyl iodide C화학적 특성, 용도, 생산
용도
Protein degrader builiding block Pomalidomide-PEG6-butyl iodide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant iodoalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant iodo group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.Pomalidomide-PEG6-butyl iodide 준비 용품 및 원자재
원자재
준비 용품
Pomalidomide-PEG6-butyl iodide 공급 업체
글로벌( 18)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 |
1924344760@confluore.cn | China | 2996 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 |
info@SuperLan-chem.com | China | 9943 | 58 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 |
1924344760@qq.com | China | 4824 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 |
1927928688@qq.com | China | 1385 | 58 |
Shaanxi borno biotechnology co., LTD | +86-13759708231 |
asherw9@hotmail.com | China | 2351 | 58 |
Shanghai Haohong Pharmaceutical Co., Ltd. | 4008210725 4008210725 |
malulu@leyan.com | China | 54986 | 58 |
Zhengzhou convergence chemical co., LTD | 0371-0371-55153829 18003835034 |
2853979819@qq.com | China | 9530 | 58 |
Pomalidomide-PEG6-butyl iodide 관련 검색:
E3 ligase Ligand-Linker Conjugates 50
Pomalidomide-PEG3-CO2H
Pomalidomide-PEG2-N3
Pomalidomide-PEG4-azide
Pomalidomide-PEG2-butyl iodide
E3 Ligase Ligand-Linker Conjugates 22
4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Pomalidomide-PEG4-CO2H
E3 Ligase Ligand-Linker Conjugates 1
POMALIDOMIDE-PEG2-CO2H
Pomalidomide-PEG1-azide
Pomalidomide-PEG5-CO2H
POMALIDOMIDE-PEG1-CO2H
Pomalidomide-O-C4-NH2
Propanoic acid, 3-[[17-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-3,6,9,12,15-pentaoxaheptadec-1-yl]oxy]-
Pomalidomide-PEG3-N3