잘시타빈
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잘시타빈 속성
- 녹는점
- 217-218 °C(lit.)
- 끓는 점
- 350.9°C (rough estimate)
- 알파
- D25 +81° (c = 0.635 in water)
- 밀도
- 1.2605 (rough estimate)
- 굴절률
- 78 ° (C=0.5, H2O)
- 저장 조건
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- 용해도
- DMSO(약간 용해됨, 가열), 메탄올(약간 용해됨), 물(약간 용해됨, 초음파 처리)
- 물리적 상태
- 가루
- 산도 계수 (pKa)
- 14.44±0.10(Predicted)
- 색상
- 무색의
- 수용성
- 19&C에서 5~10g/100mL
- Merck
- 14,10109
- BRN
- 654956
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
- InChIKey
- WREGKURFCTUGRC-POYBYMJQSA-N
- CAS 데이터베이스
- 7481-89-2(CAS DataBase Reference)
- IARC
- 2B (Vol. 76) 2000
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,C | ||
---|---|---|---|
위험 카페고리 넘버 | 40-36/37-34 | ||
안전지침서 | 22-36-45-36/37/39-27-26 | ||
WGK 독일 | 3 | ||
RTECS 번호 | HA3870000 | ||
F 고인화성물질 | 10-23 | ||
HS 번호 | 2934990002 | ||
유해 물질 데이터 | 7481-89-2(Hazardous Substances Data) |
잘시타빈 C화학적 특성, 용도, 생산
개요
Zalcitabine is an orally active dideoxynucleoside andog for combination use with zidovudine in advanced HIV infection and also as monotherapy for AIDS patients who cannot tolerate or have not responded to zidovudine. It has a similar mechanism of action (inhibition of reverse transcriptase) to didanosine. Like didanosine, its side effect profile includes peripheral neuropathy. Unlike zidovudine, zalcitabine does not cause bone marrow suppression.화학적 성질
White to Off-White Cyrstalline PowderIndications
Zalcitabine (ddC, Hivid) is a cytidine analogue active against HIV-1, HIV-2, and hepatitis B virus. It is used for the treatment of HIV infection in adults and asymptomatic children as part of a multidrug regimen. It may be less effective than the other nucleoside inhibitors and is used less frequently.정의
ChEBI: A pyrimidine 2',3'-dideoxyribonucleoside compound having cytosine as the nucleobase.일반 설명
Zalcitabine, 2',3'-dideoxycytidine or ddCyd, is an analog ofcytosine that demonstrates activity against HIV-1 and HIV-2,including strains resistant to AZT. The potency (in peripheralblood mononuclear cells) is similar to that of AZT, but thedrug is more active in populations of monocytes andmacrophages as well as in resting cells.The oral bioavailability of zalcitabine is over 80% in adultsand less in children.The major dose-limiting side effect isperipheral neuropathy, characterized by pain, paresthesias,and hypesthesia, beginning in the distal lower extremities.These side effects are typically evident after several months oftherapy with zalcitabine. A potentially fatal pancreatitis is anothertoxic effect of treatment with ddC. The drug has beenapproved for the treatment of HIV infection in adults with advanceddisease who are intolerant to AZT or who have diseaseprogression while receiving AZT. ddC is combined with AZTfor the treatment of advanced HIV infection.
공기와 물의 반응
Water soluble.반응 프로필
Zalcitabine may be sensitive to prolonged exposure to light.화재위험
Flash point data for Zalcitabine are not available; however, Zalcitabine is probably combustible.Pharmacology
Peripheral neuropathy occurs in up to 50% of patients taking zalcitabine. Stomatitis, esophageal ulceration, hepatotoxicity, rash, and pancreatitis may occur. Zalcitabine should be used with caution in individuals with a history of pancreatitis, liver disease, or alcohol abuse. Dosage adjustment is necessary for individuals with renal impairment. Zalcitabine should not be used in combination with didanosine, lamivudine, or stavudine.Pharmacokinetics
Zalcitabine (ddC) is a useful alternate drug to ZDV and is given in combination with ZDV when CD4 cell counts fall to less than 300 cells/mm3 . Monotherapy with ddC is more active than ZDV. Its oral bioavailability is 87%, and its plasma half-life is approximately 1 hour. In low doses (0.005 mg/kg every 4 hours), ddC produces sustained decrease in p24 antigen level and increase in CD4 cell counts. The CSF fluid/plasma ratio of ddC is 0.2. Following oral administration, bioavailability of ddC is less than 80%, which is further reduced when taken with food. The mean maximum plasma concentration of the drug also is reduced from 25.2 to 15.5 ng/mL when the drug was taken with food.부작용
It has side effects, such as stomatitis, rash, fever, malaise, arthritis, and arthralgia.신진 대사
Dideoxyuridine is the major metabolite in urine and feces. The drug penetrates the blood-brain barrier. The major toxicity of ddC is peripheral neuropathy, in which case it should be discontinued. In some cases, pancreatitis occurs when given alone or in combination with ZDV."잘시타빈 준비 용품 및 원자재
원자재
아세틸브로마이드
팔라듐
수소
시틴딘
암모니아(가스)
에틸렌다이아민테트라아세트산
2-아세톡시-2-메틸프로피오닐브로마이드
수산화 트리메틸벤질암모늄
Palladium hydroxide
무수초산
N4-Acetylcytidine
아연
POLY(4-VINYLPYRIDINE)
ZALCITABINE관련화합물A(50MG)(2′,3′-DIDEHYDRO-2′,3′-DIDEOXYCYTIDINE)
(S)-5-Hydroxymethyldihydrofuran-2-one
암모니아수
준비 용품
잘시타빈 공급 업체
글로벌( 358)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12446 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 973 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7621 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Nanjing Baifuli Technology Co., Ltd. | +86-15335185688 |
sales@unisyn.cn | CHINA | 332 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |