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3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 구조식 이미지
카스 번호:
13669-70-0
상품명:
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
동의어(영문):
NEFOPAM;Nefopan;Nefopami;fenazoxine;HCL Nefopam;(?)-Nefopam;NEFOPAMI HCL;Induced insect;Nefopam HCL CP2000;Nefopanhydrochloride
CBNumber:
CB2379272
분자식:
C17H19NO
포뮬러 무게:
253.34
MOL 파일:
13669-70-0.mol

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 속성

끓는 점
396.54°C (rough estimate)
밀도
1.0078 (rough estimate)
굴절률
1.5400 (estimate)
저장 조건
Sealed in dry,2-8°C
산도 계수 (pKa)
9.16±0.70(Predicted)
CAS 데이터베이스
13669-70-0(CAS DataBase Reference)

안전

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene C화학적 특성, 용도, 생산

Originator

Ajan,Kettelhack Riker,W. Germany,1976

용도

Nefopam is a non-opioid non-steroidal centrally acting analgesic.

용도

Analgesic.

Manufacturing Process

The starting material is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol) of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml tetrahydrofuran and then slowly added in small portions to a solution of 5.5 grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with cooling and stirring. The mixture is then refluxed for 18 hours, cooled and then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium hydroxide and 16 ml water. After removal of precipitated salts by filtration, the solution remaining is concentrated under reduced pressure and the residue dried to yield 19.5 grams of crude product. Yield after conversion to the hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to 133°C.
5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until all the benzene is distilled off. The residual oil is heated to 105°C and held at this temperature for 1 hour, then cooled and dissolved in 30 ml water. This aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide, extracted with ether, and the extracts washed with water, dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP 238° to 242°C.

상표명

Acupan (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant, Antidepressant

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 준비 용품 및 원자재

원자재

준비 용품


3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene 공급 업체

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