벤즈히드롤
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벤즈히드롤 속성
- 녹는점
- 65-67 °C (lit.)
- 끓는 점
- 297-298 °C (lit.)
- 밀도
- 1.0120 (rough estimate)
- 증기압
- 0.000076 hPa (20 °C)
- 굴절률
- 1.5727 (estimate)
- 인화점
- 160 °C
- 저장 조건
- Store below +30°C.
- 용해도
- 0.52g/l 불용성
- 물리적 상태
- 결정질 고체
- 산도 계수 (pKa)
- 13.55±0.20(Predicted)
- 색상
- 흰색에서 베이지색
- 냄새
- 100.00%에서. 잡초가 많은 녹색 장미
- ?? ??
- 녹색
- 수용성
- 물에 약간 용해됩니다.
- Merck
- 14,1090
- BRN
- 1424379
- 안정성
- 안정적인. 타기 쉬운. 강한 산화제, 산 염화물, 산 무수물, 산과 호환되지 않습니다.
- LogP
- 2.670
- CAS 데이터베이스
- 91-01-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36-24/25 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | DC7452000 | ||
| 위험 참고 사항 | Irritant | ||
| TSCA | Yes | ||
| HS 번호 | 29062900 | ||
| 독성 | LD50 orally in Rabbit: 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg | ||
| 기존화학 물질 | KE-28311 |
벤즈히드롤 C화학적 특성, 용도, 생산
화학적 성질
off-white powder용도
- Benzhydrols are industrially important compounds. On oxidation Benzhydrols yields Benzophenone, which are useful synthones for fullerenes, bioactive oxygen heterocycles, dyes and medicines. Various Cr (VI) and other oxidizing agents are used for oxidizing benzhydrol.
- Benzhydrol is widely used as intermediates in pharmaceuticals (including antihistamines), agrochemicals, perfumes and other organic compounds. It is used as a fixative in the perfume industry. It is involved in polymerization reaction as a terminating group. It is used as precursor to prepare modafinil, benztropine and diphehydramine.
- Intermediate in the preparation of Modafinil (M482500).
화학 반응
Benzhydrol is oxidized to benzophenone, by sodium hypochlorite (commonly known as bleach) in the presence of a phase-transfer catalyst.Synthesis: In a 20-mL green capped vial, place 1.5 mL of ethyl acetate, 100 mg (0.54 mmol) of benzhydrol and a few drops of methyltricaprylammonium chloride solution (Stark's catalyst or tricaprylmethylammonium chloride). Add a half-inch magnetic stirring bar, and stir until all reagents are dissolved. Cool the solution in an ice bath and add 2 mL of 5% NaOCl (aq) (bleach) dropwise using a 2.5- mL syringe. After the addition of the hypochlorite is complete, allow the reaction to stir for five minutes in the ice-water bath and then stir for a period of one hour at room temperature.
Reduction of benzophenone to benzhydrol.
4MPDC (4-Methyl pyridinium di chromate) is used as oxidizing agent to oxidize benzhydrol. PDC is a mild and selective oxidizing agent and is soluble in water and many organic solvents. Therefore, advantage over inorganic dichromate.
일반 설명
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standardsPurification Methods
Crystallise benzhydrol from hot H2O or pet ether (b 60-70o), pet ether containing a little *benzene, from CCl4, or EtOH (1mL/g). An additional purification step includes passage of a *benzene solution through an activated alumina column. It sublimes in a vacuum. Also recrystallise it three times from MeOH/H2O [Naguib J Am Chem Soc 108 128 1986]. [Beilstein 6 IV 4648.]벤즈히드롤 준비 용품 및 원자재
원자재
아연
벤조페논
(Trimethylsiloxy)diphenylmethane
2H-Pyran, 2-(diphenylmethoxy)tetrahydro-
TRIMETHYL(PHENYL)TIN
2,4,6-Triphenylboroxin
디페닐메탄
디펜히드라민
디페닐 메틸 브롬화물
준비 용품
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
C.I. 산 녹색 16
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
1-BENZHYDRYLPIPERAZINE
인디고 카르민
2-Chlorotrityl chloride
1,1',1'',1'''-(Oxydimethylidyne)Tetrakis Benzene
BENZHYDRYL ACETATE
benzhydryl thiocyanate
Stearoylbenzoylmethane
벤즈히드롤 공급 업체
글로벌( 590)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| TAIZHOU DKD CHEMICAL CO., LTD. | +8618658336633 |
yf.chen@tzdkdchem.com | China | 134 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12456 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 |
admin@hbouhuang.com | China | 2259 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15928 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
| Jiangsu Qingquan Chemical Co., Ltd. | +86-571-86589381,86589382,86589383 |
sales1@qqpharm.com | CHINA | 154 | 55 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 |
kaia@neputrading.com | China | 1011 | 58 |