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N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 구조식 이미지
카스 번호:
93102-05-7
상품명:
N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine
동의어(영문):
)-N-trimethyL;cas:93102-05-7;-N-(methoxymethyL;N-(Methoxymethyl)-N-(trimethyl;N-(Methoxymethyl)-N-(trimethylsilyl) benzylamine;Benzyl-methoxymethyl-trimethylsilanylmethylamine;N-Benzyl-N-methoxymethyltrimethylsilylmethanamine;N-(Methoxymethyl)-N-(Trimethylsilylmethyl)Benzylam;benzyl(MethoxyMethyl)[(triMethylsilyl)Methyl]aMine;N-Benzyl-N-(methoxymethyl)trimethylsilylmethylamine
CBNumber:
CB2715045
분자식:
C13H23NOSi
포뮬러 무게:
237.41
MOL 파일:
93102-05-7.mol

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 속성

끓는 점
76 °C0.3 mm Hg(lit.)
밀도
0.928 g/mL at 25 °C(lit.)
굴절률
n20/D 1.492(lit.)
인화점
151 °F
저장 조건
Keep in dark place,Sealed in dry,Room Temperature
용해도
Soluble in chloroform, ethyl acetate.
물리적 상태
Liquid
산도 계수 (pKa)
7.29±0.50(Predicted)
Specific Gravity
0.928
색상
Clear colorless to light yellow
감도
Moisture & Light Sensitive
Hydrolytic Sensitivity
2: reacts with aqueous acid
BRN
4311216
InChIKey
RPZAAFUKDPKTKP-UHFFFAOYSA-N
CAS 데이터베이스
93102-05-7(CAS DataBase Reference)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-37/39
유엔번호(UN No.) 1993
WGK 독일 3
위험 등급 3
포장분류
HS 번호 29319090
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H227 가연성 액체 인화성 액체 구분 4 경고 P210, P280, P370+P378, P403+P235,P501
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
예방조치문구:
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine MSDS


N-Benzyl-N-(methoxymethyl)trimethylsilylmethylamine

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine C화학적 특성, 용도, 생산

화학적 성질

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine is clear colorless to light yellow liquid

물리적 성질

bp 77–80°C/0.5 mmHg.

용도

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine is useful reagent in synthesizing N-benzyl substituted pyrrolidines by [3+2] cycloaddition to α,ßunsaturated esters.

용도

N-Benzyl-N-(methoxymethyl)- N-trimethylsilylmethylamine (1) is a valuable reagent for in situ generation of the N-benzyl azomethine ylide (2). It is generally preferred over alternative silylmethylamine precursors6–8 because of ease of handling and use. The ylide (2) is most conveniently generated from (1) using a catalytic amount of trifluoroacetic acid as described by Achiwa.Alternative catalysts include LiF, TBAF,Me3SiOTf–CsF, or Me3SiI–CsF. Mechanistic studies provide evidence that the reactive intermediate generated from (1) with either CF3CO2H or F? is a 1,3-dipolar species. Reaction of (2) with alkenes provides an efficient convergent route to pyrrolidine derivatives. Alkynes afford 3-pyrrolines which can be converted into pyrroles.The ylide (2) reacts most readily with electron deficient alkenes and alkynes since this pairing results in a narrow dipole HOMO–dipolarophile LUMO energy gap.Examples of suitable dipolarophiles include unsaturated esters, ketones, imides,nitriles,and sulfones. Cycloaddition occurs with complete cis stereospecificity (eq 1) which is consistent with a concerted mechanism. Dipolarophiles containing an endocyclic double bond afford fused bicyclic pyrrolidines, whereas substrates with an exocyclic double bond provide access to spirocyclic systems.

제조 방법

most conveniently prepared by treatment of benzylamine with chloromethyltrimethylsilane followed by formaldehyde and methanol.Access to higher ether homologs is achieved by replacing methanol with the appropriate alcohol. An alternate procedure involves alkylation of lithium N-benzyltrimethylsilymethylamide with methoxymethyl chloride.

N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 준비 용품 및 원자재

원자재

준비 용품


N-(Methoxymethyl)-N-(trimethylsilylmethyl)benzylamine 공급 업체

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AB PharmaTech,LLC
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