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벤질벤조에이트

벤질벤조에이트
벤질벤조에이트 구조식 이미지
카스 번호:
120-51-4
한글명:
벤질벤조에이트
동의어(한글):
벤질벤조에이트;벤조산벤질;안식향산벤질;벤조산벤질
상품명:
Benzyl benzoate
동의어(영문):
Zylate;ASCABIN;Scabide;Benylate;ASCABIOL;Colebenz;Scabagen;Scabanca;Scabitox;Scobenol
CBNumber:
CB9152283
분자식:
C14H12O2
포뮬러 무게:
212.24
MOL 파일:
120-51-4.mol

벤질벤조에이트 속성

녹는점
18 °C
끓는 점
323-324 °C(lit.)
밀도
1.118 g/mL at 20 °C(lit.)
증기압
1 mm Hg ( 125 °C)
굴절률
n20/D 1.568(lit.)
FEMA
2138 | BENZYL BENZOATE
FEMA
2797 | OCTANAL
인화점
298 °F
저장 조건
2-8°C
용해도
Miscible with ethanol, alcohol, chloroform, ether, oils.
물리적 상태
Liquid
색상
Clear colorless
수용성
practically insoluble
Merck
14,1127
JECFA Number
24
BRN
2049280
안정성
Stable. Substances to be avoided include strong oxidizing agents. Combustible.
InChIKey
SESFRYSPDFLNCH-UHFFFAOYSA-N
CAS 데이터베이스
120-51-4(CAS DataBase Reference)
NIST
Benzyl Benzoate(120-51-4)
EPA
Benzoic acid, phenylmethyl ester(120-51-4)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,N
위험 카페고리 넘버 22-51/53
안전지침서 25-61-46
유엔번호(UN No.) UN 3082 9 / PGIII
WGK 독일 2
RTECS 번호 DG4200000
자연 발화 온도 896 °F
TSCA Yes
위험 등급 9
HS 번호 29163100
유해 물질 데이터 120-51-4(Hazardous Substances Data)
독성 LD50 in rats, mice, rabbits, guinea pigs (g/kg): 1.7, 1.4, 1.8, 1.0 orally (Draize)
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H401 수생생물에 유독함 수생 환경유해성 물질 - 급성 구분 2 P273, P501
H411 장기적 영향에 의해 수생생물에 유독함 수생 환경유해성 물질 - 만성 구분 2
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P270 이 제품을 사용할 때에는 먹거나, 마시거나 흡연하지 마시오.
P273 환경으로 배출하지 마시오.
P330 입을 씻어내시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

벤질벤조에이트 MSDS


Benzyl benzoate

벤질벤조에이트 C화학적 특성, 용도, 생산

개요

그것은 벤질 알콜과 벤조산의 에스테르이다.그것은 점성의 액체 또는 고체 플레이크를 형성하고 약한, 달콤한 발사믹 냄새를 갖는다. 그것은 많은 꽃 (e. g. tuberose, hyacinth)이며 페루와 톨루스 봉숭아의 balsam의 구성 성분이다.

용도

벤질 벤조 에이트는 수의학 병원의 살비제, 살충제 및 살균제로 사용됩니다. 벤질 벤조 에이트의 다른 용도는 염료 담체이다, 셀룰로스 유도체 용 용매, 가소제, 향수 업계의 정착액.벤질 벤조 에이트 (BnBzO)는 중개 및 곤충 방충제이다. 그것은 진드기에 치명적이기 때문에 진드기의 scarcoptes scabiei에 의한 피부 감염 인 옴을 치료하기 위해 사용되는 오래된 제제 중 하나입니다. 그것은 또한 머리와 몸의 이가 출몰의 치료를 위해 사용될 수 있습니다. 그 작용 메카니즘은 곤충의 신경계에 대한 독성 효과를 발휘함으로써 더욱더 죽음을 초래한다. 또한 알려지지 않은 메커니즘을 통해 진드기 난에 유독합니다. 또한 염료 운반체, 셀룰로오스 유도체의 용매, 가소제 및 정착액뿐만 아니라 츠거 (chiggers), 진드기 (ticks) 및 모기 (mogquitoes)에 대한 방충제로 사용될 수 있습니다.

생산

벤질 벤조 에이트는 염기의 존재 하에서 벤조산과 벤질 알콜의 반응에 의해 공업 적으로 제조된다. 택일 적으로, 이는 메틸 벤조 에이트와 벤질 알콜의 에스테르 교환 반응에 의해 생성된다.그것은 또한 톨루엔 산화에 의한 벤조산 합성의 부산물이다.그것은 또한 벤즈 알데하이드의 tishchenko 반응에 의해 생성 될 수있다.

개요

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.

화학적 성질

Benzyl Benzoate is the main component of Peru balsam oil. It occurs in fairly large amounts in a number of blossom concretes and absolutes (e.g., tuberose and hyacinth). It forms either a viscous liquid or solid flakes (mp 21–22°C) and has a weak, sweet, balsamic odor. It is prepared either by transesterification of technical methyl benzoate with benzyl alcohol or from benzyl chloride and sodium benzoate. A third process starts with benzaldehyde, which is converted in high yield into benzyl benzoate in the presence of sodium or aluminum benzylate (Tishchenko reaction). Benzyl benzoate is used in perfumery as a fixative and as a modifier in heavy blossom fragrances.

화학적 성질

Benzyl benzoate has a light, balsamic odor reminiscent of almond and a sharp, pungent taste.

화학적 성질

Colourless oily liquid with pleasant aromatic odour

화학적 성질

Benzyl benzoate is a clear, colorless, oily liquid with a slightly aromatic odor. It produces a sharp, burning sensation on the tongue. At temperatures below 178℃ it exists as clear, colorless crystals.

출처

Contained in Peru balsam and in the concrete and absolute of tuberose flowers, hyacinth, Narcissus jonquilla L., and Dianthus caryophillus L.; also in the oil of ylang-ylang and in Tolu balsam. Reported found in American cranberry, cinnamon bark, cassia leaf, corn oil and hog plum (Spondias mombins L.).

용도

Benzyl benzoate, as a topical solution, may be used as an antiparasitic insecticide to kill the mites responsible for the skin condition scabies , for example as a combination drug of benzyl benzoate/disulfiram.
It has other uses :
a fixative in fragrances to improve the stability and other characteristics of the main ingredients
a food additive in artificial flavors
a plasticizer in cellulose and other polymers
a solvent for various chemical reactions
a treatment for sweet itch in horses
a treatment for scaly leg mites in chickens.

용도

benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.

용도

antiarteriosclerotic, hypolipaemic, hepatoprotectant

용도

Benzyl Benzoate has seen use as an insecticide, as well as a solvent for various chemical reactions.

용도

Used to kill lice and the mites responsible for the skin condition scabies.

용도

As solvent of cellulose acetate, nitrocellulose and artificial musk; substitute for camphor in celluloid and plastic pyroxylin Compounds; perfume fixative; in confectionery and chewing gum flavors.

생산 방법

Benzyl benzoate is a constituent of Peru balsam and occurs naturally in certain plant species. Commercially, benzyl benzoate is produced synthetically by the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by the reaction of sodium benzylate with benzaldehyde.

제조 방법

By the dry esterification of sodium benzoate and benzoyl chloride in the presence of triethylamine or by reaction of sodium benzylate on benzaldehyde.

상표명

Pharmaceutic necessity for Dimercaprol [Injection]. Benylate (Sterling Winthrop).

Taste threshold values

Taste characteristics at 30 ppm: balsamic, fruity with powdery and berry nuances.

위험도

Irritant to eyes, skin.

Pharmaceutical Applications

Benzyl benzoate is used as a solubilizing agent and nonaqueous solvent in intramuscular injections at concentrations of 0.01–46.0% v/v, and as a solvent and plasticizer for cellulose and nitrocellulose. It is also used in the preparation of spray-dried powders using nanocapsules.
However, the most widespread pharmaceutical use of benzyl benzoate is as a topical therapeutic agent in the treatment of scabies. Benzyl benzoate is also used therapeutically as a parasiticide in veterinary medicine.
Other applications of benzyl benzoate include its use as a pediculicide, and as a solvent and fixative for flavors and perfumes in cosmetics and food products.

색상 색인 번호

Benzyl benzoate is the ester of benzyl alcohol and benzoic acid. It is contained in Myroxylon pereirae and Tolu balsam. It is used in acaricide preparations against Sarcoptes scabiei or as a pediculicide. Direct contact may cause skin irritation, but rarely allergic contact dermatitis. As a fragrance allergen, benzyl benzoate has to be mentioned by name in EU cosmetics.

Clinical Use

Benzyl benzoate is a naturally occurring ester obtained fromPeru balsam and other resins. It is also prepared syntheticallyfrom benzyl alcohol and benzoyl chloride. The ester isa clear colorless liquid with a faint aromatic odor. It is insolublein water but soluble in organic solvents.
Benzyl benzoate is an effective scabicide when appliedtopically. Immediate relief from itching probably resultsfrom a local anesthetic effect; however, a complete cureis frequently achieved with a single application of a 25%emulsion of benzyl benzoate in oleic acid, stabilized withtriethanolamine. This preparation has the additionaladvantage of being essentially odorless, nonstaining, andnonirritating to the skin. It is applied topically as a lotionover the entire dampened body, except the face.

Safety

Benzyl benzoate is metabolized by rapid hydrolysis to benzoic acid and benzyl alcohol. Benzyl alcohol is then further metabolized to hippuric acid, which is excreted in the urine.
Benzyl benzoate is widely used as a 25% v/v topical application in the treatment of scabies and as an excipient in intramuscular injections and oral products. Adverse reactions to benzyl benzoate include skin irritation and hypersensitivity reactions. Oral ingestion may cause harmful stimulation of the CNS and convulsions. Benzyl benzoate should be avoided by perople with perfume allergy.
LD50 (cat, oral): 2.24 g/kg
LD50 (dog, oral): 22.44 g/kg
LD50 (guinea pig, oral): 1.0 g/kg
LD50 (mouse, oral): 1.4 g/kg
LD50 (rabbit, oral): 1.68 g/kg
LD50 (rabbit, skin): 4.0 g/kg
LD50 (rat, oral): 0.5 g/kg
LD50 (rat, skin): 4.0 g/kg

Chemical Synthesis

This colorless liquid is formally the condensation product of benzoic acid and benzyl alcohol. It can also be generated from benzaldehyde by the Tishchenko reaction.

저장

Benzyl benzoate is stable when stored in tight, well-filled, lightresistant containers. Exposure to excessive heat (above 408℃) should be avoided.

비 호환성

Benzyl benzoate is incompatible with alkalis and oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (IM injections and oral capsules). Included, as an active ingredient, in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

벤질벤조에이트 준비 용품 및 원자재

원자재

준비 용품


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