티메로살
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티메로살 속성
- 녹는점
- 234-237 °C (dec.)(lit.)
- 인화점
- 250 °C
- 저장 조건
- Store at RT.
- 용해도
- 메탄올: 0.1 g/mL, ≤ 10 테 CF
- 물리적 상태
- 가루
- 색상
- 흰색에서 황백색까지
- 수소이온지수(pH)
- 6.0~8.0 (10g/L, 25℃)
- 수용성
- 1G/ML(20℃)
- Merck
- 13,9389
- BRN
- 8169555
- 안정성
- 안정적인. 햇빛에 분해될 수 있습니다. 강산, 강염기, 강산화제, 요오드, 중금속 염과 호환되지 않습니다.
- InChI
- InChI=1S/C7H6O2S.C2H4.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H,2H3;;/q;-1;2*+1/p-1
- InChIKey
- RTKIYNMVFMVABJ-UHFFFAOYSA-L
- SMILES
- O=C1[O-][Hg+2]([CH-]C)[SH-]C2=CC=CC=C12.[Na+]
- CAS 데이터베이스
- 54-64-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+,N,T | ||
---|---|---|---|
위험 카페고리 넘버 | 26/27/28-33-50/53 | ||
안전지침서 | 13-28-36-45-60-61-28A | ||
유엔번호(UN No.) | UN 2025 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | OV8400000 | ||
F 고인화성물질 | 8 | ||
TSCA | Yes | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29310095 | ||
유해 물질 데이터 | 54-64-8(Hazardous Substances Data) | ||
독성 | LD50 s.c. in rats: 98 mg/kg (Mason) | ||
기존화학 물질 | KE-13896 | ||
유해화학물질 필터링 | 97-1-140 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 수은 또는 그 화합물과 수은화합물을 1% 이상 함유한 혼합물. 다만 황화 제이수은(Mercuric sulfide), 요오드화 제일수은(Mercuric iodide), 오레인산 수은(Mercuric oleate), 아미노 염화 제이수은(Amino mercury(II) chloride), 뇌산 제이수은(Mercury(II) fulminate) 및 그 중 하나를 함유한 혼합물은 제외 |
티메로살 C화학적 특성, 용도, 생산
화학적 성질
Thimerosal is a light cream-colored crystalline powder with a slight, characteristic odor.용도
Thimerosal is used as ophthalmie preservative; topieal anti-infective; topical veterinary antibacterial and antifungal agent; bacteriostat; fungistat; preservative in vaccines, antitoxins, skin-testing allergens, antiseptics, contact-Iens solutions, and cosmetic products like eye makeup.정의
ChEBI: An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.생산 방법
Thimerosal is prepared by the interaction of ethylmercuric chloride, or hydroxide, with thiosalicylic acid and sodium hydroxide, in ethanol (95%).일반 설명
Light cream-colored crystalline powder with a slight odor: pH (1% aqueous solution) 6.7. Slight odor.공기와 물의 반응
Water soluble.반응 프로필
Thimerosal is incompatible with strong oxidizing agents and strong bases. The oxidation of Thimerosal is greatly accelerated by traces of copper ions. Incompatible with acids, iodine, heavy metal salts and many alkaloids. Can be absorbed by rubber caps. . Stable in air, but not sunlight. May discolor on exposure to light. Dilute aqueous solutions are fairly stable to heat but sensitive to light. Solutions are less stable to heat when acidic than when alkaline. Solutions are most stable to light at pH 5 to 7. Solutions are unstable to heat but not to light in the presence of copper, iron or zinc ions but not in the presence of calcium or magnesium ions.위험도
Toxic by ingestion, inhalation.화재위험
Flash point data for Thimerosal are not available; however, Thimerosal is probably combustible.Pharmaceutical Applications
Thimerosal has been used as an antimicrobial preservative in biological and pharmaceutical preparations since the 1930s.It is used as an alternative to benzalkonium chloride and other phenylmercuric preservatives, and has both bacteriostatic and fungistatic activity. Increasing concerns over its safety have, however, led to questions regarding its continued use in formulations.
Thimerosal is also used in cosmetics and to preserve soft contact lens solutions.
Therapeutically, thimerosal is occasionally used as a bacteriostatic and fungistatic mercurial antiseptic, which is usually applied topically at a concentration of 0.1% w/w. However, its use is declining owing to its toxicity and effects on the environment.
색상 색인 번호
Thiomersal is an organic mercury salt prepared by react- ing ethylmercuric chloride (or ethylmercuric hydroxide) with thiosalicylic acid. It is still used as a disinfectant and a preservative agent, but less commonly than previ- ously, especially in contact lens fluids, eyedrops, and vaccines. The ethylmercuric moiety is the major aller- genic determinant, sometimes associated with mercury sensitivity. Thiomersal is an indicator of photosensitiv- ity to piroxicam, through its thiosalicylic moiety.Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. An eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. An ophthalmic preservative, a topical anti-infective, topical veterinary antibacterial and antifungal agent. An FDA over-the-counter drug. When heated to decomposition it emits very toxic fumes of Hg, Na2O, and SOx. See also MERCURY COMPOUNDS.환경귀착
Thimerosal is a cream-colored crystalline powder; it is water soluble and thus the compound can leach into groundwater. Aquatic toxicity has been demonstrated at relatively high concentrations.저장
Thimerosal is stable at normal temperatures and pressures; exposure to light may cause discoloration.Aqueous solutions may be sterilized by autoclaving but are sensitive to light. The rate of oxidation in solutions is increased by the presence of trace amounts of copper and other metals. Edetic acid or edetates may be used to stabilize solutions but have been reported to reduce the antimicrobial efficacy of thimerosal solutions.
The solid material should be stored in a well-closed container, protected from light, in a cool, dry place.
Purification Methods
Recrystallise this antibacterial from EtOH/Et2O. HIGHLY TOXIC. [Trikojus Nature 158 472 1940, Beilstein 10 III 213.]비 호환성
Incompatible with aluminum and other metals, strong oxidizing agents, strong acids and bases, sodium chloride solutions, lecithin, phenylmercuric compounds, quaternary ammonium compounds, thioglycolate, and proteins. The presence of sodium metabisulfite, edetic acid, and edetates in solutions can reduce the preservative efficacy of thimerosal.In solution, thimerosal may be adsorbed by plastic packaging materials, particularly polyethylene. It is strongly adsorbed by treated or untreated rubber caps that are in contact with solutions.
When it was used with cyclodextrin, the effectiveness of thimerosal was reduced; however, this was related to the lipid nature of the other ingredients in the preparation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; ophthalmic, otic, and topical preparations). Included in nonparenteral and parenteral medicines licensed in the UK. In the UK, the use of thimerosal in cosmetics is limited to 0.003% w/w (calculated as mercury) as a preservative in shampoos and haircreams, which contain nonionic emulsifiers that would render other preservatives ineffective. The total permitted concentration (calculated as mercury) when mixed with other mercury compounds is 0.007% w/w. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.티메로살 준비 용품 및 원자재
원자재
준비 용품
티메로살 공급 업체
글로벌( 229)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shanghai Rochi Pharmaceutical Co.,Ltd. | 21-38751876 +8615000076078 |
info@rochipharma.com | China | 431 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9357 | 55 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29823 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |