Cefonicid
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Cefonicid 속성
- 밀도
- 1.92±0.1 g/cm3(Predicted)
- 산도 계수 (pKa)
- -1.23±0.50(Predicted)
안전
Cefonicid C화학적 특성, 용도, 생산
개요
Cefonicid has an unesterified D-mandelic acid moiety at C-7 and a methylsulfothiotetrazole group at C-3. The latter is related to the MTT moiety mentioned above under cefamandole nafate; however, the clotting problems and Antabuse-like side effects associated with MTT have not been reported with cefonicid. The extra acid group in the C-3 side chain leads to this molecule being sold as an injectable disodium salt. Pain and discomfort at IM sites is experienced by some patients, as is a burning sensation and phlebitis. Cefonicid has a longer half-life than the other members of its group but achieves this at the price of somewhat lower potency against Gram-positive bacteria and aerobes. The drug is somewhat unstable, needs to be protected from light and heat, and may yellow or darken. If modest, however, this does not necessarily mean that the potency has decreased significantly, but overt precipitation does. Kirby-Bauer disk testing may overestimate the sensitivity of β-lactamase–producing bacteria to this agent, so some extra caution in interpretation of laboratory results is required.용도
A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial정의
ChEBI: A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.Antimicrobial activity
Activity against Gram-positive and Gram-negative organisms in vitro is depressed by the presence of 50% serum. It is highly bound to plasma protein (98%) and has an extended plasma half-life of 4.5–5 h. A 1 g intramuscular dose achieves a mean peak plasma concentration of around 83 mg/L. Following a 1 g intravenous bolus dose, mean peak plasma concentrations of 130–300 mg/L have been reported. In patients treated for community-acquired pneumonia, concentrations of 2–4 mg/L have been found in sputum.It is predominantly excreted by renal secretion, 83–89% being recovered unchanged in the urine over 24 h. Plasma half-life is linearly related to creatinine clearance. As a result of its high protein binding it is not removed by hemodialysis.
It is generally well tolerated; pain on injection, rash and positive Coombs’ test are reported in some patients. It has been used to treat respiratory, soft tissue and urinary infections. Available in Italy.
Cefonicid 준비 용품 및 원자재
원자재
DL-MANDELAMIDE
소디움 아지이드
소듐 2-에틸헥사노에이트
메틸 카바메이트
5-메틸-1H-테트라졸
Methanol solution of sodium methoxide
Ion exchange resin column
초산에틸
중탄산나트륨(중조)
Alcohol soluble
Methyl dithiocarbamate
Aminomethanesulfonic acid
이소프로필알코올
요오드 메탄
준비 용품
Cefonicid 공급 업체
글로벌( 68)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9348 | 55 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9320 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 29220 | 58 |
BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Hebei Duling International Trade Co. LTD | +8618032673083 |
sales05@hbduling.cn | China | 15745 | 58 |
ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 |
admin@jiuzhou-chem.com;jamie@jiuzhou-chem.com;alice@jiuzhou-chem.com | China | 20000 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49999 | 58 |
Cefonicid 관련 검색:
N,N-디메틸아세트아미드 아세트아마이드 아세트아미노펜 글리콜아미드 싸이오아세트아마이드 산소, 냉각된 액체
CHLOROPHOSPHONAZO III
5-Mercapto-1H-tetrazole-1-methanesulfonic acid disodium salt
Sodium cefamandole
7-TMCA
7-Phenyl-acetamido-deacetoxy-cephalosporanic-acid
5-Mercapto-1H-tetrazole-1-methane sulphonic acid
CEFONICID DISODIUM,CEFONICID SODIUM,CEFONICID DISODIUM SALT
Cefamandole
CEFONICID SODIUM FOR INJECTION
Cefonicid
Cefonicid disodium sterile
5-MERCAPTO-1,2,3,4-TETRAZOLE-1-METHYL SULFONIC ACID DISODIUM SALT. ( SMT , FOR CEFONICID )