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아세트아마이드

아세트아마이드
아세트아마이드 구조식 이미지
카스 번호:
60-35-5
한글명:
아세트아마이드
동의어(한글):
아세트아마이드;아세트아미드;아세트산아미드;에탄아미드;메탄카르복스아미드;아세타마이드
상품명:
Acetamide
동의어(영문):
CH3CONH2;AMIDE C2;Acetamid;Actamide;ACETAMIDE;NCI-C02108;ETHANAMIDE;acetylamine;Acetylamide;Acetamide,99%
CBNumber:
CB3453432
분자식:
C2H5NO
포뮬러 무게:
59.07
MOL 파일:
60-35-5.mol

아세트아마이드 속성

녹는점
78-80 °C(lit.)
끓는 점
221 °C(lit.)
밀도
1.159
증기압
1 mm Hg ( 65 °C)
굴절률
1.4274
인화점
220-222°C
저장 조건
Store at RT
용해도
H2O: 0.5 g/mL, Hazen ≤50
산도 계수 (pKa)
0.63(at 25℃)
물리적 상태
Crystals
색상
White
수용성
2000 g/L (20 ºC)
Merck
14,43
JECFA Number
1592
BRN
1071207
안정성
Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
InChIKey
DLFVBJFMPXGRIB-UHFFFAOYSA-N
CAS 데이터베이스
60-35-5(CAS DataBase Reference)
NIST
Acetamide(60-35-5)
EPA
Acetamide(60-35-5)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn
위험 카페고리 넘버 40
안전지침서 36/37
유엔번호(UN No.) UN 3077 9/PG 3
WGK 독일 1
RTECS 번호 AB4025000
F 고인화성물질 3
TSCA Yes
HS 번호 29241900
유해 물질 데이터 60-35-5(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 7000 mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H320 눈에 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2B 경고 P264, P305+P351+P338,P337+P313
H351 암을 일으킬 것으로 의심됨 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
H361 태아 또는 생식능력에 손상을 일으킬 것으로 의심됨 생식독성 물질 구분 2 경고 P201, P202, P281, P308+P313, P405,P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P202 모든 안전 조치 문구를 읽고 이해하기 전에는 취급하지 마시오.
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P281 요구되는 개인 보호구를 착용하시오
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P405 밀봉하여 저장하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

아세트아마이드 MSDS


Ethanamide

아세트아마이드 C화학적 특성, 용도, 생산

개요

아세트 아미드는 아세트산으로부터 유도 된 아미드이다. 순수한 생성물은 실온에서 백색 결정질 고체이며, 아세트산 암모늄의 탈수에 의해 수득 될 수있다. 그것은 가소제 및 유기 합성의 중요한 원료로 사용됩니다.

용도

"1. 용융 아세트 아미드는 다양한 유기 및 무기 물질을위한 우수한 용매입니다. 섬유 산업에서 염료로 사용되는 용제 및 용해제와 같이 수용성이 낮은 물질을 물에 용해시킬 때 용해 보조제로 사용할 수 있습니다. 또한 가소제의 안정제, 화장품 산업의 제산제, 제지 산업의 습윤제 및 chloramphenicol과 같은 항생제 합성 용제로 널리 사용됩니다. 2. 분석 시약, 용제, 안정제, 가소제로 사용됩니다. 또한 유기 합성, 제약 산업, 염료 제조에도 사용할 수 있습니다. 3. 흡습제, 윤활제 등의 제조에도 사용됩니다."

제품 소개

아세트 아미드는 매우 인화성이 없지만 화상을 입으면 자극적 인 흄을 방출합니다. 흡입, 섭취, 피부 및 눈 접촉은 유독하며 피부와 눈 접촉은 발적 또는 통증을 유발할 수 있습니다.

개요

Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.

화학적 성질

Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.

화학적 성질

Acetamide occurs as hexagonal colourless deliquescent crystals with a musty odour. It is incompatible with strong acids, strong oxidising agents, strong bases, and triboluminescent materials. Acetamide is used primarily as a solvent, a plasticiser, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastic and chemical industries.

용도

  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.

일반 설명

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.

공기와 물의 반응

Deliquescent. Very soluble in water.

반응 프로필

Acetamide may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).

건강위험

After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.

건강위험

Mild irritant; acute oral toxicity in animals very low; oral LD50 value (rats):7000 mg/kg; carcinogenic to animals; oraladministration caused blood and liver tumorsin mice and rats; carcinogenicity: animal limited evidence, no evidence in humans.

화재위험

The flash point of Acetamide has not been determined, but Acetamide is probably combustible.

Safety Profile

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.

잠재적 노출

Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing

효소 저해제

This simple amide (FW = 59.07 g/mol; CAS 142-26-7; M.P. = 81°C; B.P. = 222° C), Deliquescent solid; Solubility: 97 g/100 mL H2O). Target (s) : thermopsin; b-N-acetylglucosaminidase; urease, weakly inhibited ; alcohol dehydrogenase, weakly inhibited; carbonic anhydrase ; acetylcholinesterase, weakly inhibited; Na+/K+-exchanging ATPase, weakly inhibited; urea carboxylase; amidase, also alternative substrate; pyroglutamyl-peptidase I; soluble epoxide hydrolase, Ki = 37 mM; glucan 1,3-b-glucosidase; and b-N- acetylhexosaminidase.

저장

Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.

운송 방법

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required

Purification Methods

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]

비 호환성

Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.

폐기물 처리

Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.

주의 사항

During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.

아세트아마이드 준비 용품 및 원자재

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