6-티오구아닌
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6-티오구아닌 속성
- 녹는점
- ≥300 °C(lit.)
- 밀도
- 1.483 (estimate)
- 굴절률
- 1.5605 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- 물과 에탄올(96%)에 거의 녹지 않습니다. 알칼리 수산화물의 묽은 용액에 용해됩니다.
- 물리적 상태
- 동결건조된 분말
- 산도 계수 (pKa)
- pKa 8.22 (Uncertain)
- 끓는 점
- 555.4±42.0 °C(Predicted)
- 색상
- 노란색에서 녹색으로
- 수용성
- 녹는
- Merck
- 14,9337
- BRN
- 157765
- 안정성
- Stable for 1 year from date of purchase as supplied. Solutions in DMF may be stored at -20°C for up to 1 month.
- CAS 데이터베이스
- 154-42-7(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T,Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 25-23/24/25 | ||
안전지침서 | 28-36/37/39-45-28A | ||
유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
WGK 독일 | 3 | ||
RTECS 번호 | UP0740000 | ||
F 고인화성물질 | 13 | ||
위험 참고 사항 | Irritant | ||
위험 등급 | 6.1 | ||
포장분류 | III | ||
HS 번호 | 29335990 | ||
유해 물질 데이터 | 154-42-7(Hazardous Substances Data) | ||
독성 | LD50 oral in mouse: 160mg/kg |
6-티오구아닌 C화학적 특성, 용도, 생산
개요
6-Thioguanine (NSC 752, Thioguanine, 2-Amino-6-purinethiol), is an antineoplastic metabolic antagonist that inhibits DNA synthesis by being metabolically converted to 6-thioGMP. This inhibits purine biosynthesis at multiple steps, and may be phosphorylated and incorporated into DNA. In humans, it causes bone marrow depression and gastrointestinal toxicity. Due to safety problems it is currently less used as an antineoplastic agent but has some use as therapy for ulcerative colitis.화학적 성질
Crystalline, lyophilized, sterile, endot. It is white or slightly yellow powder with umami taste, easily soluble in water, but insoluble in organic solvents such as ethanol and acetone.용도
6-Thioguanine acts as an antineoplastic and purine antimetabolite. It is also useful as an inhibition of stimulated expression of TNF-related apoptosis-inducing ligand (TRAIL) protein. It is involved in the treatment of acute leukemias and Psoriasis. Further, it is used for the treatment of ulcerative colitis and autoimmune diseases.Indications
6-Thioguanine is a purine analogue structurally related to 6-mercaptopurine and azathioprine. Thioguanine interferes with several enzymes required for de novo purine synthesis, and its metabolites are incorporated into DNA and RNA, further impeding nucleic acid synthesis. The mechanism of action of thioguanine in psoriasis is not clearly understood; it has been hypothesized to affect the proliferation and trafficking of lymphocytes as well as the proliferation of keratinocytes.정의
ChEBI: 6-Thioguanine is a 2-aminopurine that is the 6-thiono derivative of 2-amino-1,9-dihydro-6H-purine.주요 응용
6-Thioguanine is a variant of guanine with hydrogen bonding at the N-7 of the purine ring. Its association with cytosine alters the dimension of the base stacking. 6-Thioguanine usage in treating inflammatory bowel disease (IBD) contributes to nodular regenerative hyperplasia (NRH) in the liver.6-Thioguanine has been used:
to induce autophagy and apoptosis in colorectal cancer cell lines HCT116
as a selection marker in the mutation and survival assay in chinese hamster lung fibroblasts culture V79
as a selection marker in clonogenic Lung metastasis assay of 4T1-luc cells
일반 설명
6-thioguanine appears as odorless or almost odorless pale yellow crystalline powder. The drug is available in 40-mg tablets for oral use. It is used to treat acute nonlymphocytic leukemia.공기와 물의 반응
6-Thioguanine may be sensitive to prolonged exposure to air. Insoluble in water.반응 프로필
6-Thioguanine is incompatible with strong oxidizing agents.화재위험
Flash point data for 6-Thioguanine are not available; however, 6-Thioguanine is probably combustible.Mechanism of action
The mechanism of action involves incorporation of thetriphosphate into DNA and RNA, resulting in inhibition ofprocessing and function. Thioguanine is a purine antagonist. It is a pro-drug that is converted intracellullarly directly to thioguanine monophosphate (also called 6-thioguanylic acid) (TGMP) by the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGPRT). TGMP is further converted to the di- and triphosphates, thioguanosine diphosphate (TGDP) and thioguanosine triphosphate (TGTP). The cytotoxic effect of thioguanine is a result of the incorporation of these nucleotides into DNA. Thioguanine has some immunosuppressive activity.1 Thioguanine is specific for the S phase of the cell cycle.부작용
Dose-related myelosuppression is the major adverse effect produced by 6-thioguanine. Patients deficient in thiopurine methyltransferase (TPMT), a cytosolic enzyme required for metabolism of 6-thioguanine, are at heightened risk. Other adverse effects include gastrointestinal complaints and elevations of liver transaminases. There have been rare reports of more serious hepatotoxicity, including acute hepatitis, acute cholestasis, and hepatic venoocclusive disease.Safety Profile
Poison by ingestion andintraperitoneal routes. Human mutation data reported. Anexperimental teratogen. Other reproductive effects. Ahuman skin irritant. When heated to decomposition itemits very toxic fumes of SOx and NOx.Purification Methods
It crystallises from H2O as needles. It has UV at 258 and 347nm (H2O, pH 1) and 242, 270 and 322nm max (H2O, pH 11). [Elion & Hitchings J Am Chem Soc 77 1676 1955, Fox et al. J Am Chem Soc 80 1669 1958.] It is an antineoplastic agent [Kataoka et al. Cancer Res 44 519 1984]. [Beilstein 26 III/IV 3926.]6-티오구아닌 준비 용품 및 원자재
원자재
무수부틸산
에틸알코올
5'—NUCLEOTIDE
구아닌
포스포디에스테라제I
6-클로로구아닌
알엔에이
삼황화사인
ANION EXCHANGE RESIN 717
Guanine hydrochloride
Polyurethane foam plastic
Ion exchange resin column
초산에틸
염산
Dialysis tubing
아세트산(빙초산)
수산화나트륨
Anhydrous pyridine
Syrup, NF
나트륨하이드로설파이드
3′,5′-사이클릭아데닐산
Industrial ammonia
5'-아데닐산
석유 에테르
준비 용품
6-티오구아닌 공급 업체
글로벌( 348)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5873 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 |
sales1@chuanghaibio.com | China | 5895 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
6-티오구아닌 관련 검색:
6-머캡토퓨린 구아닌 6-티오구아닌
Ancitabine
6-Methylthioguanine
6-Thioguanosine hydrate
1,9-DIHYDRO-6H-PURINE-6-THIONE
6-N-HEPTYLMERCAPTOPURINE
2-Amino-6-mercaptopurine-13C2,15N
6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE
6-(Methylthio)purine
6-thioinosine-5'-triphosphate
8-AZA-6-HYDROXY-2-MERCAPTOPURINE
1,7,8,9-tetrahydro-8-thioxo-6H-purin-6-one
6-METHYLMERCAPTOPURINE RIBOSIDE
2-MERCAPTOPURINE
6-METHYL-D3-MERCAPTOPURINE
2,6-Dithiopurine