1,1,2-트라이클로로에테인
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1,1,2-트라이클로로에테인 속성
- 녹는점
- -37 °C
- 끓는 점
- 110-115 °C (lit.)
- 밀도
- 1.435 g/mL at 25 °C (lit.)
- 증기압
- 30.3 at 25 °C (quoted, Mackay et al., 1982)
- 굴절률
- n
20/D 1.471(lit.)
- 인화점
- 11 °C
- 저장 조건
- 2-8°C
- 용해도
- 에탄올과 클로로포름에 용해됨(US EPA, 1985)
- 물리적 상태
- 액체
- 색상
- 무색의
- 수용성
- 4g/L(20℃)
- Merck
- 14,9637
- BRN
- 1731726
- Henry's Law Constant
- 8.70 at 30 °C (headspace-GC, Sanz et al., 1997)
- 노출 한도
- Potential occupational carcinogen. NIOSH REL: TWA 10 ppm (45 mg/m3), IDLH 100 ppm; OSHA PEL: TWA 10 ppm (adopted).
- Dielectric constant
- 7.2800000000000002
- 안정성
- 안정적인.
- LogP
- 2.05-2.49 at 20℃ and pH7
- CAS 데이터베이스
- 79-00-5(CAS DataBase Reference)
- IARC
- 3 (Vol. 52, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn,Xi,T,F | ||
---|---|---|---|
위험 카페고리 넘버 | 20/21/22-40-66-39/23/24/25-23/24/25-11-23-21/22 | ||
안전지침서 | 9-36/37-46-45-16-7 | ||
유엔번호(UN No.) | 3082 | ||
OEB | A | ||
OEL | TWA: 10 ppm (45 mg/m3) [skin] (Chloroethanes) | ||
WGK 독일 | 3 | ||
RTECS 번호 | KJ3150000 | ||
위험 참고 사항 | Irritant | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29031990 | ||
유해 물질 데이터 | 79-00-5(Hazardous Substances Data) | ||
독성 | Acute oral LD50 for mice 378 mg/kg, rats 580 mg/kg (quoted, RTECS, 1985). | ||
IDLA | 100 ppm | ||
기존화학 물질 | KE-34069 |
1,1,2-트라이클로로에테인 C화학적 특성, 용도, 생산
화학적 성질
1,1,2-Trichloroethane is a colorless, nonflammable (must be pre-heated before ignition can occur) liquid Sweet, chloroform-like odor.물리적 성질
Colorless liquid with a pleasant, sweet, chloroform-like odor용도
The use of 1,1,2-trichloroethane is quite restrictive. It is used to a slight extent as a specialty solvent and mostly as a chemical intermediate; a solvent for fats, waxes, natural resins, alkaloids, and various other organic materials; as an intermediate in production of vinylidene chloride and teflon tubing; and as a component of adhesives. The availability of other less toxic solvents discourages its use. More than 95% of this compound manufactured in the United States is consumed in producing vinylidene chloride. Domestic production is about 410 million pounds. It must not be confused with its much less toxic isomer, 1,1,1- trichloroethane.정의
ChEBI: A member of the class of chloroethanes that is ethane substituted by chloro groups at positions 1, 1 and 2.일반 설명
A clear light colored liquid. Flash point between 0 and 74°F. Insoluble in water and slightly denser than water. Hence sinks in water. May be toxic by inhalation.반응 프로필
1,1,2-Trichloroethane is sensitive to light and heat. Incompatible with strong oxidizing agents and strong bases. Reacts violently with sodium, potassium, magnesium, and aluminum. Attacks some plastics, rubber and coatings.건강위험
Inhalation causes irritation of the nose, throat, and lungs. High concentrations may cause death by respiratory failure. Highly toxic by ingestion; may cause liver or kidney damage or myocardial irritability. Causes severe irritation of the gastrointestinal tract. Vapor may produce superficial skin burns or defatting type dermatitis and may irritate the eyes.Safety Profile
Suspected carcinogen with experimental carcinogenic data. Poison by ingestion, intravenous, and subcutaneous routes. Moderately toxic by inhalation, skin contact, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. An eye and severe skin irritant. Has narcotic properties and acts as a local irritant to the eyes, nose, and lungs. It may also be injurious to the liver and kidneys. Incompatible with potassium. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORINATED HYDROCARBONS, ALIPHATIC; and other trichloroethane entries,잠재적 노출
1,1,2-Trichloroethane is used as an intermediate in the production of vinylidine chloride, and a component of adhesives; as a solvent; but is not as widely used as is its isomer 1,1,1-Trichloroethane; it is an isomer of 1,1,1-Trichloroethane but should not be confused with it toxicologically. 1,1,2-Trichloroethane is comparable to carbon tetrachloride and tetrachloroethane in toxicity. Forms a flammable vaporair mixture at 43℃ and higher.Carcinogenicity
According to the NCI, 1,1,2-trichloroethane has been included in the NCI bioassay program, in which it was fed by gavage to rats and mice. As in many of these studies with hepatotoxic compounds, hepatocellular carcinomas occurred in mice but not in rats fed for 78 weeks. Rats were kept an additional 35 weeks and mice 13 weeks following treatment. Pheochromocytomas were also observed in mice. The doses fed were 92 and 46 mg/kg/ day for rats and 390 and 195 mg/kg/day for mice. Mortality was accelerated in female mice but not in the rats or male mice. The NCI report does not indicate the degree of noncarcinogenic histopathology produced by these doses.In a bioassay conducted by NCI, technical-grade (92.7% pure) 1,1,2-trichloroethane was administered by gavage in corn oil to Osborne–Mendel rats and B6C3F1 mice: (50/species/sex/dose) for each of two doses and 20 animals/ species/sex for each of two control groups. Administration was five times/week for 78 weeks, during which time doses for rats were increased from 70 and 30 mg/kg/day to 100 and 50 mg/kg/day and doses for mice were increased from 300 and 150 mg/kg/day to 400 and 200 mg/kg/day. By two statistical tests, treatment of mice was found to be associated with increased incidence of hepatocellular carcinomas. A dose-related increase in pheochromocytomas was also confirmed in female mice. Tumors found in treated but not control rats included adrenal cortical carcinomas; transitional cell carcinomas of kidney; renal tubular adenomas; and hemangiosarcomas of spleen, pancreas, abdomen, and subcutaneous tissue. There was, however, no statistically significant increase in tumor incidence in rats as a function of treatment.
IRIS classifies this compound as C, possible human carcinogen on the basis of hepatocellular carcinomas and pheochromocytomas in one strain of mice. Carcinogenicity was not shown in rats. 1,1,2-Trichloroethane is structurally related to 1,2-dichloroethane, a probable human carcinogen. There are no human carcinogenicity data.
환경귀착
Biological. Vinyl chloride was reported to be a biodegradation product from an anaerobic digester at a wastewater treatment facility (Howard, 1990). Under aerobic conditions, Pseudomonas putida oxidized 1,1,2-trichloroethane to chloroacetic and glyoxylic acids. Simultaneously, 1,1,2-trichloroethane is reduced to vinyl chloride exclusively (Castro and Belser,1990). In a static-culture-flask screening test, 1,1,2-trichloroethane was statically incubated in the dark at 25 °C with yeast extract and settled domestic wastewater inoculum. Biodegradative activity was slow to moderate, concomitant with a significant rate of volatilization (Tabak et al., 1981).Chemical/Physical. Products of hydrolysis include chloroacetaldehyde, 1,1-dichloroethylene, and HCl. The aldehyde is subject to hydrolysis forming hydroxyacetaldehyde and HCl (Kollig, 1993). The reported half-life for this reaction at 20 °C is 170 yr (Vogel et al., 1987). Under alkaline conditions, 1,1,2-trichloroethane hydrolyzed to 1,2-dichloroethylene. The reported hydrolysis half-life in water at 25 °C and pH 7 is 139.2 yr (Sata and Nakajima, 1979).
운송 방법
UN3082 Environmentally hazardous substances, liquid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.Purification Methods
Purify the chloroethane as for 1,1,1-trichloroethane above. [Beilstein 1 IV 139.]비 호환성
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong acids, strong caustics; chemically active metals;, such as aluminum, magnesium powders, sodium, potassium. Attacks some plastics, rubber, coatings, steel, and zinc.폐기물 처리
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced.참고 문헌
[1] Michela Romanini. “Simultaneous Orientational and Conformational Molecular Dynamics in Solid 1,1,2-Trichloroethane.” The Journal of Physical Chemistry C 122 10 (2018): 5774–5783.1,1,2-트라이클로로에테인 준비 용품 및 원자재
원자재
준비 용품
1,1,2-트라이클로로에테인 공급 업체
글로벌( 224)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 20292 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21667 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 +8613506123987 |
marketing1@neostarunited.com | China | 9105 | 58 |
1,1,2-트라이클로로에테인 관련 검색:
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