클로로포름

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클로로포름 MSDS

Methyl trichloride

클로로포름 C화학적 특성, 용도, 생산

물성

클로로포름은 상온에서 특이한 냄새와 약간 달고 찌릿한 맛이 나며.
휘발성을 가진 무색의 투명한 액체로, 에탄올이나 벤젠에는 녹지만.
물에는 잘 녹지 않는 비교적 무거운 화합물입니다.

존재

많은 종류의 해조류들이 바다에서 클로로포름을 생산하고.
토양에서는 곰팡이종들이 클로로포름을 생산하는 것으로 알려져 있습니다.

용도

클로로포름이 사람에게 처음 마취제로서 투약되었고,마취 효과가 빠르고 강하게 나타나 수술용 마취제로 널리 사용되게 되었습니다.하지만 시간이 지나면서 마취용 클로로포름 사용에 의해 환자가 사망하는 사건들이 발생하고,
더욱 안전한 마취제들이 새롭게 등장하며 더 이상 마취제로 사용되지 않게 되었습니다.
클로로포름은 현재 주로 살충제와 곰팡이 제거제로 많이 사용되며,지방과 오일, 고무, 알칼로이드, 왁스 등의 용매제 및 분석 시약으로도 사용되고 있습니다.

독성

클로로포름은 피부를 자극하고, 국소를 마비시키는 작용을 하며,증기를 흡입하면 대뇌를 마비시키는 작용이 있습니다.

포장, 보관 및 운송

산화를 방지하기 위해 갈색 병에 넣어 마개를 꼭 닫아서 차고 어두운 곳에 보존해야 한다. 에탄올에 표백분을 작용시키든가, 아세톤에 하이포염소산칼슘을 작용시키면 생기며, 이 밖에 메탄올 염소화하여 염화메틸이나 염화메틸렌을 제조할 때에도 부생한다.

개요

Chloroform is a trichlorinated organic substance with the chemical formula of CHCl3. It is a clear liquid at room temperature and has a pleasant, sweet odor. Chloroform is only slightly soluble in water and evaporates quickly into surrounding air, increasing the risk of inhalation exposure. In addition, chloroform persists for a long time in both water and air. There are no natural sources of chloroform, but this contaminant enters the environment through a variety of industrial operations, including the chlorination of water. Humans can be exposed to chloroform through inhalation, ingestion, and dermal contact.
Chloroform has a relatively narrow margin of safety and has been replaced by better inhalation anesthetics. In addition, it is believed to be toxic to the liver and kidneys and may cause liver cancer. Chloroform was once widely used as a solvent, but safety and environmental concerns have reduced this use as well. Nevertheless, chloroform has remained an important industrial chemical.

화학적 성질

Chloroform is a noncombustible, clear, colorless liquid with a pleasant, sweet odor. The Odor Threshold is 12 ppm.

물리적 성질

Chloroform is a clear, colorless liquid with a pleasant odor and sweet burning taste. It is used to make hydrochloroflurocarbons (HCFCs), as a solvent for organic chemicals, and in chemical synthesis. Its use in many commercial products has been eliminated in recent decades because of its toxic and carcinogenic properties. It was once used extensively as an anesthetic, in medicines, in dry cleaning, and in refrigerants.

역사

Chloroform (CHCl3) was first discovered in 1831 by American physician Samuel Guthrie; and independently a few months later by Frenchman Eugène Soubeiran and Justus von Liebig in Germany. Chloroform was named and chemically characterised in 1834 by Jean-Baptiste Dumas. Its anaesthetic properties were noted early in 1847 by Marie-Jean-Pierre Flourens. Unlike ether, chloroform's characteristically sweet odour isn't irritating, although inhalation of concentrated chloroform vapour may cause irritation of exposed mucous surfaces. Chloroform is a more effective anaesthetic than nitrous oxide.
In 1864, the Report of Chloroform Committee of Royal Medical and Chirurgical Society endorsed chloroform as Britain's favourite anaesthetic. But ether was safer for patients.
In 1871, leading anaesthetic manufacturer Edward E. Squibb of Brooklyn estimated [New York Medical Journal (April 1871) 13;389] that of 400,000 administrations of anaesthesia in the USA in 1870, chloroform was the agent used in some 50%, ether for 40%, and other gases and mixtures accounted for the rest.

용도

Chloroform is a widely used industrial and laboratory solvent. It is a volatile chlorinated organic solvent whose vapors have a narcotic effect.Due to its light sensitivity, it may undergo degradation with time. This can be suppressed by adding ethanol as a stabilizer. The addition will increase the polarity of the solvent and potentially impact certain applications.

1. Chloroform has been used as a solvent for dissolving lipids and also as a cleansing agent.
2. It may also be used in solvent extraction process and also for recrystallization.
3. Suitable for HPLC, spectrophotometry, environmental testing
4. Facilitates recovery of the aqueous phase of PCRs which have been overlaid with mineral oil.
5. Meets ACS specifications.

생산 방법

Chloroform was first synthesized by treating acetone or ethanol with calcium hypochlorite or sodium hypochlorite bleaching powder. Chlorination of ethanol produces acetaldehyde and then trichloroacetaldehyde. Acetaldehyde yields chloroform and the formate ion by action of hydroxide ion. Acetone is chlorinated to trichloroacetone, which then splits into chloroform and the acetateion. The modern industrial preparation of chloroform involves the chlorination of methane or methyl chloride, CH₃Cl, using heat to substitute the chlorine atoms for hydrogen. The reaction is carried out at approximately 500°C. Hydrochlorination by reacting methanol and hydrogen chloride can also be used to produce chloroform.

정의

ChEBI: A one-carbon compound that is methane in which three of the hydrogens are replaced by chlorines.

World Health Organization (WHO)

Chloroform was formerly widely used in pharmaceutical preparations as a solvent and preservative as well as for its anaesthetic and flavouring properties. By the late 1970s reservations concerning its safety, including positive results in a carcinogenicity screening programme sponsored by the National Cancer Institute in the USA, had led to considerable restrictions in its use in pharmaceutical preparations. While many pharmaceutical products containing chloroform have been withdrawn or reformulated to exclude this substance, it may still be incorporated in toothpastes and other specified products in some countries, subject to statutorily-imposed concentration limits. (Reference: (IARCCD) Chloroform: IARC Monograph, 20(20), 401-427, 1979)

일반 설명

A clear colorless liquid with a characteristic odor. Denser (12.3 lb / gal) than water and slightly soluble in water. Hence sinks in water. Nonflammable under most conditions, but burns under extreme conditions. May cause illness by inhalation, skin absorption or ingestion. Used as a solvent, to make other chemicals, as a fumigant.

공기와 물의 반응

Slightly soluble in water. Dissolves in water to form a corrosive solution of hypochlorous acid which decomposes on standing to chlorine, oxygen, and chloric acid.

반응 프로필

A mixture of acetone and Chloroform in a residue bottle exploded. Since addition of acetone to Chloroform in the presence of base will result in a highly exothermic reaction, Chloroform is thought that a base was in the bottle. [MCA Case History 1661(1970)]. Powdered aluminum and carbon tetrachloride(also methyl chloride and Chloroform or mixtures of these chemicals) exploded when heated(to 153°C.) and by impact, [Chem. Eng. News 32:258(1954); UL Bull. Research 34(1945), ASESB Pot. Incid. 39(1968)]. An inadequately cooled addition of sodium to a Chloroform-methanol mixture (sodium methoxide) caused a violent explosion, [MCA Case History No. 693]. Chloroform is incompatible with dinitrogen tetraoxide, fluorine, sodium metal and alcohols, nitromethane, and triisopropylphosphine.

위험도

A possible carcinogen. Toxic by inhalation; anesthetic; prolonged inhalation or ingestion may be fatal. It has been prohibited by FDA from use in drugs, cosmetics, and food packaging, including cough medicines, toothpastes, etc. Nonflammable. Will burn on prolonged exposure to flame or high temperature. Liver and embryo/fetal damage, and central nervous system impairment.

건강위험

Chloroform is classified as moderately toxic. Probable oral lethal dose for humans is 0.5 to 5 g/kg (between 1 ounce and 1 pint) for a 150 lb. person. The mean lethal dose is probably near 1 fluid ounce (44 g). It is a human suspected carcinogen. Also, it is a central nervous system depressant and a gastrointestinal irritant. It has caused rapid death attributable to cardiac arrest and delayed death from liver and kidney damage.

화재위험

Container may explode in the heat of fire. When heated Chloroform liberates phosgene, hydrogen chloride, chlorine and toxic and corrosive oxides of carbon and chlorine. Chloroform explodes when in contact with aluminum powder or magnesium powder or with alkali metals (e.g., lithium, sodium, and potassium) and dinitrogen tetroxide. Chloroform reacts vigorously with acetone in the presence of potassium hydroxide or calcium hydroxide. Chloroform is oxidized by strong oxidizers such as chromic acid forming phosgene and chlorine. Chloroform reacts vigorously with triisopropylphosphine. Chloroform develops acidity from prolonged exposure to air and light.

인화성 및 폭발성

Chloroform is noncombustible. Exposure to fire or high temperatures may lead to formation of phosgene, a highly toxic gas.

화학 반응

Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

잠재적 노출

Chloroform was one of the earliest general anesthetics, but its use for this purpose has been abandoned because of toxic effects. Chloroform is widelyused as a solvent (especially in the lacquer industry); in the extraction and purification of penicillin and other pharmaceuticals; in the manufacture of artificial silk, propellents, plastics, floor polishes, and fluorocarbons (R-22); and in sterilization of catgut. Chemists and support workers as well as hospital workers are believed to be at a higher risk than the general population. Chloroform is widely distributed in the atmosphere and water (including municipal drinking water primarily as a consequence of chlorination). A survey of 80 American cities by EPA found chloroform in every water system in levels ranging from ,0.3 to 311 ppb.

Carcinogenicity

Chloroform is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

저장

In the presence of light, chloroform undergoes autoxidation to generate phosgene; this can be minimized by storing this substance in the dark under nitrogen. Commercial samples of chloroform frequently contain 0.5 to 1% ethanol as a stabilizer.

운송 방법

UN1888 Chloroform, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

비 호환성

Though nonflammable, chloroform decomposes to form hydrogen chloride, phosgene, and chlorine upon contact with a flame. Chloroform decomposes slowly in air and light. Reacts violently with strong caustics (bases), strong oxidants, chemically active metals (especially powders), such as aluminum, lithium, magnesium, potassium, and sodium, causing fire and explosion hazard. Attacks plastic, rubber, and coatings. Corrodes iron and other metals in the presence of moisture.

폐기물 처리

Incineration, preferably after mixing with another combustible fuel. Care must be exercised to assure complete combustion to prevent the formation of phosgene. An acid scrubber is necessary to remove the halo acids produced. Where possible it should be recovered, purified by distillation, and returned to the supplier.

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