N-Boc-1-aminocyclobutanecarboxylic acid
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N-Boc-1-aminocyclobutanecarboxylic acid 속성
- 녹는점
- 129-133 °C(lit.)
- 끓는 점
- 362.1±21.0 °C(Predicted)
- 밀도
- 1.18±0.1 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Sealed in dry,Room Temperature
- 용해도
- 메탄올에 용해됨
- 산도 계수 (pKa)
- 4.14±0.20(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 밝은 갈색까지
- BRN
- 7994003
- InChI
- InChI=1S/C10H17NO4/c1-9(2,3)15-8(14)11-10(7(12)13)5-4-6-10/h4-6H2,1-3H3,(H,11,14)(H,12,13)
- InChIKey
- ROVVUKFHORPDSM-UHFFFAOYSA-N
- SMILES
- C1(NC(OC(C)(C)C)=O)(C(O)=O)CCC1
- CAS 데이터베이스
- 120728-10-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
N-Boc-1-aminocyclobutanecarboxylic acid C화학적 특성, 용도, 생산
개요
N-Boc-1-aminocyclobutanecarboxylic acid (1-((tert-Butoxycarbonyl)amino)cyclobutanecarboxylic acid) is an organic compound used in the preparation of intermediates for Boc-apalutamide. Apalutamide is a prescription drug used to treat prostate cancer.Synthesis
Under stirring, add 1-aminocyclobutylcarboxylic acid (500mg, 4.34mmol) to 10mL of 0.5M sodium hydroxide solution, and add 10mL of 1,4-dioxane and di-tert-butyl dicarbonate (1.42g, 6.51 mmol), react for 15 hours. Extract with diethyl ether (20 mL × 2), add hydrochloric acid dropwise until the pH of the aqueous phase is 4, and extract with ethyl acetate (30 mL × 3). The organic phases were then combined, washed with saturated sodium chloride solution (20mL×2), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to obtain the product N-Boc-1-aminocyclobutanecarboxylic acid (750mg, white solid), yield:80.6%.N-Boc-1-aminocyclobutanecarboxylic acid 준비 용품 및 원자재
원자재
1-Aminocyclobutanecarboxylic acid
5,7-디아자스피로[3.4]옥탄-6,8-디온
시클로부탄카르복실산,1-[[(1,1-디메틸에톡시)카르보닐]aMino]-,에틸에스테르
1-브로모-사이클로부탄카르복실산에틸에스테르
준비 용품
N-Boc-1-aminocyclobutanecarboxylic acid 공급 업체
글로벌( 336)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Changzhou AniKare Pharmatech Co., Ltd. | +86-0519-8359-8696 +8618018249389 |
sales@anikare.com | China | 9259 | 58 |
Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 |
mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9308 | 55 |
AB PharmaTech,LLC | 323-480-4688 |
United States | 989 | 55 | |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 |
sales@nbinno.com | CHINA | 925 | 58 |
Shanghai Arbor Chemical Co., Ltd. | 021-60451682 |
act@arborchemical.com | CHINA | 906 | 58 |
Win-Win Chemical CO., Limited | 0086-577-64498589 |
sales@win-winchemical.com | CHINA | 998 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 |
sales@ansciepchem.com | CHINA | 4242 | 58 |