아라키돈산

아라키돈산
아라키돈산 구조식 이미지
카스 번호:
506-32-1
한글명:
아라키돈산
동의어(한글):
아라키돈산;아라키도닉애씨드
상품명:
Arachidonic acid
동의어(영문):
ARA;Arachidonate;Arachidonic;5,8,11,14-EICOSATETRAENOIC ACID;icosa-5,8,11,14-tetraenoic acid;Arachidonic Acid (peroxide free);(5Z,8Z,11Z,14Z)-Icosa-5,8,11,14-tetraenoic acid;20:4n-6;CIS-5,8,11,14-EICOSATETRAENOIC ACID;Single-Use Arachidonic Acid (peroxide free)
CBNumber:
CB8112259
분자식:
C20H32O2
포뮬러 무게:
304.47
MOL 파일:
506-32-1.mol
MSDS 파일:
SDS

아라키돈산 속성

녹는점
-49 °C (lit.)
끓는 점
169-171 °C/0.15 mmHg (lit.)
밀도
0.922 g/mL at 25 °C (lit.)
굴절률
n20/D 1.4872(lit.)
인화점
>230 °F
저장 조건
2-8°C
용해도
에탄올: 10mg/mL
산도 계수 (pKa)
4.75±0.10(Predicted)
물리적 상태
기름
색상
무색~연황색
수용성
실질적으로 불용성
Merck
14,765
BRN
1713889
Concentration
1 mCi/ml
Solvent
Ethanol under argon
Specific Activity
200-240 Ci/mmol
안정성
감광성, 온도 민감성
InChIKey
YZXBAPSDXZZRGB-DOFZRALJSA-N
LogP
6.99
CAS 데이터베이스
506-32-1(CAS DataBase Reference)
NIST
Arachidonic acid(506-32-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험 카페고리 넘버 19
안전지침서 24/25-19
유엔번호(UN No.) UN1170 - class 3 - PG 2 - Ethanol
WGK 독일 3
RTECS 번호 CE6675000
F 고인화성물질 8-10-23
HS 번호 29161900
독성 dns-mus:mmr 10 mg/L CRNGDP 5,1123,84
기존화학 물질 KE-20931
그림문자(GHS): GHS hazard pictogramsGHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P233 용기를 단단히 밀폐하시오. 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 보관하시오.
P240 용기와 수용설비를 접지 및 접합시키시오.
P241 폭발 방지용 장비[전기적/환기/조명/...]을(를) 사용하시오.
P242 스파크가 발생하지 않는 도구를 사용하시오
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
NFPA 704
1
1 0

아라키돈산 MSDS


Icosa-5,8,11,14-tetraenoic acid

아라키돈산 C화학적 특성, 용도, 생산

개요

Arachidonic acid (AA, sometimes ARA) is a polyunsaturated omega-6 fatty acid 20:4(ω-6). It is the counterpart to the saturated arachidic acid found in peanut oil, (L. arachis – peanut.).

화학적 성질

In chemical structure, arachidonic acid is a carboxylic acid with a 20-carbon chain and four cis-double bonds; the first double bond is located at the sixth carbon from the omega end.
Some chemistry sources define 'arachidonic acid' to designate any of the eicosatetraenoic acids. However, almost all writings in biology, medicine and nutrition limit the term to all-cis-5,8,11,14- eicosatetraenoic acid.

용도

Arachidonic Acid is an essential fatty acid and a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes. Arachidonic Acid occurs in liver, brain, glandular organs, and depot fats of animals, in small amounts in human depot fats, and Arachidonic Acid is also a constituent of animal phosphatides.

정의

ChEBI: A long-chain fatty acid that is a C20, polyunsaturated fatty acid having four (Z)-double bonds at positions 5, 8, 11 and 14.

일반 설명

A Certified Spiking Solution? suitable for use in mass spectrometry-based fatty acid testing applications such as assessment of cardiovascular disease risk and fatty acid deficiency, and detection and quantification of arachidonic acid in nutraceuticals and dietary supplements. Arachidonic acid (cis-5,8,11,14), sometimes referred to as AA or ARA, is a polyunsaturated omega-6 fatty acid. Studies suggests that ARA as well as other fatty acids can serve as biomarkers for cardiovascular disease, and nutritional and metabolic disorders.

생물학적 활성

Endogenous free fatty acid released from phospholipids by phospholipase A 2 . Important cellular signaling mediator and precursor of eicosanoids. Metabolized by lipoxygenases, cyclooxygenases and cytochrome P450 monooxygenases.

Safety Profile

Poison by intravenous route.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits acridsmoke and irritating fumes.

Carcinogenicity

In vitro and in vivo studies indicate that inhibition of arachidonic acid metabolism inhibits the growth of malignant cells, including head and neck squamous cell carcinoma, and implicates arachadonic acid in facilitating the metastasis of these tumor cells. Arachidonic acid reaction with cyclooxygenase and lipoxygenases yield eicosanoids that can mediate prostate cancer proliferation and enhance both tumor vascularization and metastasis. Cytochrome P450 arachidonic acid epoxygenases promote cell proliferation and inhibit apoptosis in endothelial cells.

아라키돈산 준비 용품 및 원자재

원자재

준비 용품


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