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미리스틸산이소프로필에스테르

미리스틸산이소프로필에스테르
미리스틸산이소프로필에스테르 구조식 이미지
카스 번호:
110-27-0
한글명:
미리스틸산이소프로필에스테르
동의어(한글):
미리스틸산이소프로필에스테르;이소프로필미리스트산;아이소프로필미리스테이트;아이소프로필미리스테이트;이소프로필미리스트산;아이소프로필 미리스테이트;1-메틸에틸 테트라데카노에이트;아이소프로필 테트라데카노에이트;테트라데칸산 1-메틸에틸 에스터;테트라데칸산, 1-메틸에틸 에스터;프로판-2-일 테트라데카노에이트;이소프로필미리스테이트
상품명:
Isopropyl myristate
동의어(영문):
IPM;D 50;IPM-R;IPM-EX;Promyr;IPM 100;BISOMEL;Revenge;Isomyst;ESTERGEL
CBNumber:
CB9482638
분자식:
C17H34O2
포뮬러 무게:
270.45
MOL 파일:
110-27-0.mol

미리스틸산이소프로필에스테르 속성

녹는점
~3 °C (lit.)
끓는 점
193 °C/20 mmHg (lit.)
밀도
0.85 g/mL at 25 °C (lit.)
증기압
<1 hPa (20 °C)
FEMA
3556 | ISOPROPYL MYRISTATE
굴절률
n20/D 1.434(lit.)
인화점
>230 °F
저장 조건
2-8°C
용해도
<0.05mg/l
물리적 상태
Liquid
Specific Gravity
0.855 (20/4℃)
색상
Clear
수용성
Miscible with alcohol. Immiscible with water and glycerol.
Merck
14,5215
JECFA Number
311
BRN
1781127
안정성
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AXISYYRBXTVTFY-UHFFFAOYSA-N
CAS 데이터베이스
110-27-0(CAS DataBase Reference)
NIST
Isopropyl Myristate(110-27-0)
EPA
Isopropyl myristate (110-27-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 -
RTECS 번호 XB8600000
자연 발화 온도 >300 °C
TSCA Yes
HS 번호 29159080
유해 물질 데이터 110-27-0(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
기존화학 물질 KE-33355
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P321 (…) 처치를 하시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.

미리스틸산이소프로필에스테르 MSDS


Isopropyl myristate

미리스틸산이소프로필에스테르 C화학적 특성, 용도, 생산

개요

Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

화학적 성질

Pure isopropyl myristate is virtually odorless, very slightly fatty, but not rancid

화학적 성질

colourless liquid of low viscosity

화학적 성질

Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

출처

Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

용도

Isopropyl myristate is an emollient in cosmetic and pharmaceutical bases.

용도

In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

용도

isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.

생산 방법

Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

제조 방법

By conventional esterification of isopropanol with myristic acid

상표명

Estergel (Merck).

Pharmaceutical Applications

Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

색상 색인 번호

Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

Pharmacology

Isopropyl myristate is used in pharmaceutical preparations because it improves solubility and increases absorption through the skin. External uses include a non-irritating iodine preparation for disinfecting the skin (Powers & Rieger, 1963) and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes (Geistlich, 1970; Watson. 1969). Preparations for internal use include oral steroid formulations (Hirata, 1970) and anaesthetic injection solutions (Davis, Pearce & Connor, 1972).
Veterinary medications containing isopropyl myristate include oral or parenteral compositions for lungworm infections (N. V. Philips' Gloielampenfabrieken, 1964) and a spray formulation for bovine udders to treat mastitis, combat infection and improve the general skin condition (Kraus, 1965). Isopropyl myristate has been found to be an effective repository vehicle for im injection of penicillin in rabbits and for sc administration of oestrogens in ovariectomized rats (Platcow & Voss, 1954).
In assays on human forearms, vasoconstrictor activity of ointment preparations containing 0025% betamethasone 17-benzoate in white soft paraffin was increased by the presence of isopropyl myristate (Pepler, Woodford & Morrison, 1971). Donovan, Ohmart & Stoklosa (1954) noted that the good solvent properties of isopropyl myristate might increase the therapeutic activity of formulations by the apparent alteration in particle size of the active ingredients, so that further evaluation and clinical study would be necessary before its use in extemporaneous compounding could be recommended. Studies in which the antifungal activity of paraben esters solubilized by surfactants was decreased by isopropyl myristate (Matsumoto & Aoki, 1962) indicate that the effectiveness of medicinal substances may be influenced by the presence of surfactants and oily ingredients such as isopropyl myristate.

Safety

Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

신진 대사

Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

저장

Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

비 호환성

When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

미리스틸산이소프로필에스테르 준비 용품 및 원자재

원자재

준비 용품


미리스틸산이소프로필에스테르 공급 업체

글로벌( 415)공급 업체
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Capot Chemical Co.,Ltd.
+86(0)13336195806 +86-571-85586718
+86-571-85864795 sales@capotchem.com China 20012 60
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8909 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanxi Naipu Import and Export Co.,Ltd
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kaia@neputrading.com CHINA 1009 58
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
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sales@coreychem.com CHINA 29955 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 310 58
Hebei Guanlang Biotechnology Co., Ltd.
+8619930503282
sales3@crovellbio.com China 5912 58
Chongqing Chemdad Co.,Ltd
+86-19923101450
sales@chemdad.com CHINA 4000 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58

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