미리스틸산이소프로필에스테르

미리스틸산이소프로필에스테르
미리스틸산이소프로필에스테르 구조식 이미지
카스 번호:
110-27-0
한글명:
미리스틸산이소프로필에스테르
동의어(한글):
미리스틸산이소프로필에스테르;이소프로필미리스트산;아이소프로필미리스테이트;아이소프로필미리스테이트;이소프로필미리스트산;아이소프로필 미리스테이트;1-메틸에틸 테트라데카노에이트;아이소프로필 테트라데카노에이트;테트라데칸산 1-메틸에틸 에스터;테트라데칸산, 1-메틸에틸 에스터;프로판-2-일 테트라데카노에이트;이소프로필미리스테이트
상품명:
Isopropyl myristate
동의어(영문):
IPM;1-Methylethyl tetradecanoate;MYRISTIC ACID ISOPROPYL ESTER;IPM 100;BISOMEL;Propyl myristate;sopropyl myristate;ISOPROPYL TETRADECANOATE;ISO-PROPYL N-TETRADECANOATE;MYRISTIC ACID ISOPROPYL ESTER MINIMU
CBNumber:
CB9482638
분자식:
C17H34O2
포뮬러 무게:
270.45
MOL 파일:
110-27-0.mol
MSDS 파일:
SDS

미리스틸산이소프로필에스테르 속성

녹는점
~3 °C (lit.)
끓는 점
193 °C/20 mmHg (lit.)
밀도
0.85 g/mL at 25 °C (lit.)
증기압
<1 hPa (20 °C)
FEMA
3556 | ISOPROPYL MYRISTATE
굴절률
n20/D 1.434(lit.)
인화점
>230 °F
저장 조건
2-8°C
용해도
<0.05mg/L
물리적 상태
액체
색상
투명한
Specific Gravity
0.855 (20/4℃)
냄새
냄새 없는
수용성
알코올과 섞임. 물과 글리세롤과 혼합되지 않습니다.
Merck
14,5215
JECFA Number
311
BRN
1781127
안정성
안정적인. 타기 쉬운. 강한 산화제와 호환되지 않습니다.
InChIKey
AXISYYRBXTVTFY-UHFFFAOYSA-N
LogP
7.71
CAS 데이터베이스
110-27-0(CAS DataBase Reference)
NIST
Isopropyl Myristate(110-27-0)
EPA
Isopropyl myristate (110-27-0)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 36/37/38
안전지침서 26-36
WGK 독일 -
RTECS 번호 XB8600000
자연 발화 온도 >300 °C
TSCA Yes
HS 번호 29159080
유해 물질 데이터 110-27-0(Hazardous Substances Data)
독성 LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
기존화학 물질 KE-33355
그림문자(GHS): GHS hazard pictograms
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P321 (…) 처치를 하시오.
P332+P313 피부 자극이 생기면 의학적인 조치· 조언을 구하시오.
NFPA 704
1
0 0

미리스틸산이소프로필에스테르 MSDS


Isopropyl myristate

미리스틸산이소프로필에스테르 C화학적 특성, 용도, 생산

개요

Isopropyl myristate is odorless when pure. May be synthesized by conventional esterification of isopropanol with myristic acid.

화학적 성질

Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

출처

Reported found in kumquat peel oil, papaya, starfruit, plum brandy, coriander seed and loquat

용도

In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

제조 방법

By conventional esterification of isopropanol with myristic acid

생산 방법

Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

일반 설명

Isopropyl myristate is an ester of isopropyl alcohol myristic acid. It is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines. It also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

색상 색인 번호

Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

부작용

Thrapecylate myristate is a medicine used to treat head lice infestations in adults and children 4 years of age and older. Common side effects include skin irritation, rash, and contact dermatitis.

Safety

Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

신진 대사

Higher molecular weight aliphatic esters are thought to be readily hydrolysed to the corresponding alcohols and acids which are then metabolized; isopropyl myristate is undoubtedly hydrolysed to normal metabolic products (Fassett, 1963). When myristic acid (as the ethyl ester) was fed to dogs,

저장

Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

비 호환성

When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

미리스틸산이소프로필에스테르 준비 용품 및 원자재

원자재

준비 용품


미리스틸산이소프로필에스테르 공급 업체

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