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Isopropyl myristate

Chemical Properties Content Analysis Applications Production Method Toxicity
Isopropyl myristate
Isopropyl myristate structure
CAS No.
110-27-0
Chemical Name:
Isopropyl myristate
Synonyms
IPM;D 50;IPM-R;IPM-EX;Promyr;Isomyst;IPM 100;BISOMEL;Revenge;Emcol-IM
CBNumber:
CB9482638
Molecular Formula:
C17H34O2
Formula Weight:
270.45
MOL File:
110-27-0.mol

Isopropyl myristate Properties

Melting point:
-5°C
Boiling point:
193 °C20 mm Hg(lit.)
Density 
0.85 g/mL at 25 °C(lit.)
vapor pressure 
<1 hPa (20 °C)
refractive index 
n20/D 1.434(lit.)
FEMA 
3556 | ISOPROPYL MYRISTATE
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
<0.05mg/l
form 
Liquid
Specific Gravity
0.855 (20/4℃)
color 
Clear
Water Solubility 
Miscible with alcohol. Immiscible with water and glycerol.
Merck 
14,5215
JECFA Number
311
BRN 
1781127
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents.
InChIKey
AXISYYRBXTVTFY-UHFFFAOYSA-N
CAS DataBase Reference
110-27-0(CAS DataBase Reference)
NIST Chemistry Reference
Isopropyl Myristate(110-27-0)
EPA Substance Registry System
Tetradecanoic acid, 1-methylethyl ester(110-27-0)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  -
RTECS  XB8600000
Autoignition Temperature >300 °C
TSCA  Yes
HS Code  29159080
Hazardous Substances Data 110-27-0(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.

Isopropyl myristate price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 172472 Isopropyl myristate 98% 110-27-0 1l $154 2018-11-13 Buy
Sigma-Aldrich 1350400 Isopropyl myristate United States Pharmacopeia (USP) Reference Standard 110-27-0 500mg $386 2018-11-13 Buy
TCI Chemical M0481 Isopropyl Myristate >98.0%(GC) 110-27-0 25mL $20 2018-11-22 Buy
TCI Chemical M0481 Isopropyl Myristate >98.0%(GC) 110-27-0 500mL $56 2018-11-22 Buy
Alfa Aesar A18111 Isopropyl tetradecanoate, 98% 110-27-0 100ml $36.7 2018-11-13 Buy

Isopropyl myristate Chemical Properties,Uses,Production

Chemical Properties

It is a colorless and odorless liquid, and miscible with vegetable oil. It is not easy to be either hydrolyzed or become rancid. The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.

Content Analysis

Weight 1.5 g sample. Then it is determined by the method ester assay (OT-18). The equivalent factor (e) in the calculation is 135.2. Or it is determined by a non-polar column method of gas chromatography (GT-10-4).

Applications

Production Method

It is a product of esterification of myristic acid derived from re-steamed coconut coil with isopropyl alcohol.
(1)  200 kg myristic acid and 450 kg isopropyl alcohol were added into the reaction vessel in turn. After mixing, 360 kg sulfuric acid (98%) was added. The reaction mixture was heated to reflux for 10 hours. Isopropyl alcohol was then recovered, washed with ice water, and neutralized with Na2CO3 aqueous solution (10%). Under normal pressure, isopropyl alcohol and water were distilled. While under reduced pressure, isopropyl myristate was distilled (185°C/1.0kPa~195°C/2.7kPa).
(2) 90 kg isopropyl alcohol was added into the reaction vessel and then sulfuric acid as catalyst, with 5% of the total amount, was added. During mixing, 228 kg myristic acid was added slowly. The mixture was heated to reflux and water was continuously separated. Until no water was separated, the reaction temperature was reduced and probe was obtained to measure the acid value. When the acid value reached 1.5 mg KOH/g, the reaction was completed. Alkali was then added for neutralization. After the removal of water under reduced pressure, the pressure was further reduced for dealcoholization until the acid value was 0.05~1.0 mg KOH/g. The final product is then isopropyl myristate.

Toxicity

ADI is not regulated (FAO/WHO, 2001).

Chemical Properties

colourless liquid of low viscosity

Chemical Properties

Isopropyl myristate is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C. It consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.

Uses

In cosmetic and topical medicinal Preparations where good absorption through the skin is desired. A jellied isopropyl myristate was marketed as Estergel (Merck & Co.) .

Uses

isopropyl myristate is an emollient, moisturizer, binder, and skin softener that also assists in product penetration. An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg. Although isopropyl myristate is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.

Production Methods

Isopropyl myristate may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent. A high-purity material is also commercially available, produced by enzymatic esterification at low temperature.

brand name

Estergel (Merck).

Pharmaceutical Applications

Isopropyl myristate is a nongreasy emollient that is absorbed readily by the skin. It is used as a component of semisolid bases and as a solvent for many substances applied topically. Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams. For example, isopropyl myristate is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Isopropyl myristate is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions. Such microemulsions may increase bioavailability in topical and transdermal applications. Isopropyl myristate has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Isopropyl myristate is used in soft adhesives for pressuresensitive adhesive tapes.

Contact allergens

Despite wide use in cosmetics, perfumes, and topical medicaments, isopropyl myristate is a very weak sen- sitizer and a mild irritant.

Safety

Isopropyl myristate is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
LD50 (mouse, oral): 49.7 g/kg
LD50 (rabbit, skin): 5 g/kg

storage

Isopropyl myristate is resistant to oxidation and hydrolysis, and does not become rancid. It should be stored in a well-closed container in a cool, dry place and protected from light.

Incompatibilities

When isopropyl myristate comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling. Isopropyl myristate is incompatible with hard paraffin, producing a granular mixture. It is also incompatible with strong oxidizing agents.

Regulatory Status

Included in the FDA Inactive Ingredients Database (otic, topical, transdermal, and vaginal preparations). Used in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Isopropyl myristate Preparation Products And Raw materials

Raw materials

Preparation Products


Isopropyl myristate Suppliers

Global( 246)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 748 58
Capot Chemical Co.,Ltd.
+86 (0)571-855 867 18
+86 (0)571-858 647 95 sales@capotchem.com China 19918 60
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3203 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hangzhou FandaChem Co.,Ltd.
0086 158 5814 5714 (Mobile; WhatsApp; Telegram)
+86-571-56059825 fandachem@gmail.com CHINA 2561 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1730 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
GIHI CHEMICALS CO.,LIMITED
08657186217390
sales@gihichemicals.com CHINA 303 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 4669 58
Hebei Chisure Biotechnology Co., Ltd.
+8613292893290
+8613292893290 Nancy@SpeedGainpharma.com CHINA 1020 58

View Lastest Price from Isopropyl myristate manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2018-12-20 Isopropyl myristate
110-27-0
US $1.00 / kg 1kg 98%min 1000kg career henan chemical co
2019-04-23 Isopropyl myristate
110-27-0
US $10.00 / kg 1kg 99% 5000kg/month Hebei Chisure Biotechnology Co., Ltd.
2018-09-11 IPM
110-27-0
US $1.00 / G 100G 99.9% 50000tons Hebei Ruishun Trade Co.,Ltd

Isopropyl myristate Spectrum


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