2-페녹시에탄올

2-페녹시에탄올 속성

2-페녹시에탄올 MSDS

Ethylene glycol monophenyl ether

2-페녹시에탄올 C화학적 특성, 용도, 생산

개요

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

화학적 성질

clear colorless liquid

Characteristics

Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

용도

Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

생산 방법

Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

일반 설명

Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

공기와 물의 반응

Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

반응 프로필

2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

건강위험

May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

화재위험

2-Phenoxyethanol is combustible.

Pharmaceutical Applications

Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

공업 용도

2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

색상 색인 번호

Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

Safety

Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD₅₀ (rabbit, skin): 5 g/kg
LD₅₀ (rat, oral): 1.26 g/kg

저장

Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

비 호환성

The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

2-페녹시에탄올 준비 용품 및 원자재

원자재

준비 용품

2-페녹시에탄올 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Liaoning Kelong Fine Chemical Co., Ltd	+86-0419-5589997 +86-13224191133	meni@kelongchem.com	China	3	58
Suzhou Genemill Biotechnology Co.,Ltd	+86-0512-65917170; +8615862502491	aimeegao@genemill.com	China	39	58
Hebei Zhuanglai Chemical Trading Co.,Ltd	+8613343047651	admin@zlchemi.com	China	476	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12456	58
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	sales@kindchem.cn	China	1227	58
Nanjing Deda New Material Technology Co., Ltd	+8613223293093	bella@njdeda.com	China	81	58
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	deasea125996@gmail.com	China	2503	58
Shandong Juchuang Chemical Co., LTD	+86-18885615001 +86-18885615001	admin@juchuangchem.com	China	387	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@airuikechemical.com	China	994	58
Hebei Kangcang new material Technology Co., LTD	+8619133911216	fanfan@kangcang.com.cn	China	340	58

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