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2-페녹시에탄올

2-페녹시에탄올
2-페녹시에탄올 구조식 이미지
카스 번호:
122-99-6
한글명:
2-페녹시에탄올
동의어(한글):
2-페녹시에탄올;에틸렌글리콜페닐에테르;페녹시에탄올;에틸렌글리콜페닐에테르
상품명:
2-Phenoxyethanol
동의어(영문):
PhG;Arosol;dowanolep;emery6705;Dowanol EP;dowanoleph;Emery 6705;Phenoxytol;arosol[qr];PHENOXETOL
CBNumber:
CB9852958
분자식:
C8H10O2
포뮬러 무게:
138.16
MOL 파일:
122-99-6.mol

2-페녹시에탄올 속성

녹는점
11-13 °C
끓는 점
247 °C(lit.)
밀도
1.107 g/mL at 20 °C(lit.)
증기 밀도
4.8 (vs air)
증기압
0.01 mm Hg ( 20 °C)
굴절률
n20/D 1.539
FEMA
4620 | 2-PHENOXYETHANOL
인화점
>230 °F
저장 조건
room temp
용해도
soluble, clear, colorless to very faintly yellow
물리적 상태
Liquid
색상
Clear colorless
Specific Gravity
1.109 (20/4℃)
수소이온지수(pH)
7 (10g/l, H2O, 23℃)
폭발한계
1.4-9.0%(V)
수용성
30 g/L (20 ºC)
Merck
14,7257
BRN
1364011
InChIKey
QCDWFXQBSFUVSP-UHFFFAOYSA-N
CAS 데이터베이스
122-99-6(CAS DataBase Reference)
NIST
2-Phenoxyethanol(122-99-6)
EPA
Ethanol, 2-phenoxy-(122-99-6)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xn,Xi
위험 카페고리 넘버 22-36-R36-R22
안전지침서 26-S26
WGK 독일 1
RTECS 번호 KM0350000
자연 발화 온도 535 °C DIN 51794
위험 참고 사항 Irritant
TSCA Yes
HS 번호 29094990
유해 물질 데이터 122-99-6(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 1850 mg/kg LD50 dermal Rabbit > 2000 mg/kg
그림문자(GHS):
신호 어: Warning
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H302 삼키면 유해함 급성 독성 물질 - 경구 구분 4 경고 P264, P270, P301+P312, P330, P501
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.

2-페녹시에탄올 MSDS


Ethylene glycol monophenyl ether

2-페녹시에탄올 C화학적 특성, 용도, 생산

개요

Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.

화학적 성질

clear colorless liquid

화학적 성질

Phenoxyethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.

Characteristics

Phenoxyethanol is a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk. It can be used over a wide pH range. This means that other preservatives can lose their effectiveness if the product is not within the right pH range. It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.

용도

phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.

용도

Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.

용도

Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.

용도

Antimicrobial preservative; also used topically in treatment of bacterial infections.

생산 방법

Phenoxyethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.

일반 설명

Colorless liquid with a pleasant odor. Density 1.02 g / cm3. An irritant.

공기와 물의 반응

Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.

반응 프로필

2-Phenoxyethanol may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.

건강위험

May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.

화재위험

2-Phenoxyethanol is combustible.

Pharmaceutical Applications

Phenoxyethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%; it may also be used as a preservative and antimicrobial agent for vaccines.Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxyethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,

공업 용도

2-Phenoxyethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
2-Phenoxyethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould. It is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
2-Phenoxyethanol is not registered as a food additive in the EU.
Scognamiglio et al. (ref. 105) reported that 2-phenoxyethanol is a fragrance ingredient used in many fragrance mixtures (see discussion). An ester of 2-Phenoxyethanol, 2-Phenoxyethyl isobutyrate and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).

색상 색인 번호

Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl? K 400) or with parabens. Sensitization to this molecule is very rare.

Safety Profile

Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.

Safety

Phenoxyethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes. The pure material is a moderate irritant to the skin and eyes. In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
The US FDA has recommended avoiding at least one topical product containing phenoxyethanol due to concerns over inadvertant exposure to nursing infants.
LD50 (rabbit, skin): 5 g/kg
LD50 (rat, oral): 1.26 g/kg

저장

Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving. The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.

비 호환성

The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Under European regulations for cosmetics (76/768/EEC), the maximum authorized concentration (MAC) of 2-phenoxyethanol is 1.0%.

2-페녹시에탄올 준비 용품 및 원자재

원자재

준비 용품


2-페녹시에탄올 공급 업체

글로벌( 298)공급 업체
공급자 전화 팩스 이메일 국가 제품 수 이점
Zhonglan Industry Co., Ltd.
(86) 531-82956570
(86) 531-82956571 sales@zhonglanindustry.com CHINA 746 58
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21910 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20680 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1367 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32457 55
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1752 55
Xiamen AmoyChem Co., Ltd
+86 (0)592-605 1114
sales@amoychem.com CHINA 6374 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 20642 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23982 58
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58

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