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ChemicalBook >> CAS DataBase List >> AZD-9291

AZD-9291

AZD-9291 price.
  • $4 - $1800
  • Product name: AZD-9291
  • CAS: 1421373-65-0
  • MF: C28H33N7O2
  • MW: 499.61
  • EINECS:629-848-5
  • MDL Number:MFCD27988062
  • Synonyms:N-(2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxy-5-((4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl)amino)phenyl)acrylamide;Mereletinib mesylate(AZD9291);AZD9291 (free base);Osimertinib (AZD-9291);AZD9291, Osimertinib;AZD9291 Base;Osimertinib Base;AZD9291 10G
Price68 Properties Safety Information Description
68 prices
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Brand
  • aablocks
  • ACHEMBLOCK
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • J&W Pharmlab
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • TRC
Package
  • 20mg
  • 25mg
  • 50mg
  • 100MG
  • 1mg
  • 5mg
  • 10mg
  • 10mM(in1mLDMSO)
  • 250mg
  • 10mM*1mLinDMSO
  • 200mg
  • 10mM(in 1mL DMSO)
  • 500mg
  • 1000mg
  • 1g
  • 1.00g
  • 2g
  • 5g
  • 10g
  • 25g
  • 100g
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging1mg
  • Price$4
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging5mg
  • Price$5
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging10mg
  • Price$7
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging250mg
  • Price$10
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging1g
  • Price$28
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging5g
  • Price$95
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging10g
  • Price$134
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99%
  • Packaging25g
  • Price$288
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C1L
  • Product descriptionN-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98%
  • Packaging100g
  • Price$1096
  • Updated2026-05-28
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberI-9701
  • Product descriptionN-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97%
  • Packaging5G
  • Price$284
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberI-9701
  • Product descriptionN-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97%
  • Packaging1G
  • Price$81
  • Updated2026-05-27
  • Buy
  • ManufacturerACHEMBLOCK
  • Product numberI-9701
  • Product descriptionN-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97%
  • Packaging100MG
  • Price$28
  • Updated2026-05-27
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ97812
  • Product descriptionAZD-9291
  • Packaging5g
  • Price$270
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0045869
  • Product descriptionOSIMERTINIB 95.00%
  • Packaging5MG
  • Price$450.51
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1104
  • Product descriptionAZD-9291
  • Packaging500mg
  • Price$176
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1104
  • Product descriptionAZD-9291
  • Packaging10mM(in 1mL DMSO)
  • Price$90
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 1mg $4 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 5mg $5 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 10mg $7 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 250mg $10 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98% 1g $28 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98% 5g $95 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 10g $134 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 99% 25g $288 2026-05-28 Buy
aablocks AA009C1L N-[2-[[2-(Dimethylamino)ethyl]methylamino]-4-methoxy-5-[[4-(1-methyl-1H-indol-3-yl)-2-pyrimidinyl]amino]phenyl]-2-propenamide 98% 100g $1096 2026-05-28 Buy
ACHEMBLOCK I-9701 N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97% 5G $284 2026-05-27 Buy
ACHEMBLOCK I-9701 N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97% 1G $81 2026-05-27 Buy
ACHEMBLOCK I-9701 N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide 97% 100MG $28 2026-05-27 Buy
AK Scientific J97812 AZD-9291 5g $270 2021-12-16 Buy
American Custom Chemicals Corporation API0045869 OSIMERTINIB 95.00% 5MG $450.51 2021-12-16 Buy
ApexBio Technology B1104 AZD-9291 500mg $176 2026-05-06 Buy
ApexBio Technology B1104 AZD-9291 10mM(in 1mL DMSO) $90 2021-12-16 Buy
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Properties

Melting point :>188oC (dec.)
Density :1.19±0.1 g/cm3(Predicted)
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :DMSO (Slightly, Heated), Methanol (Slightly, Heated)
pka :12.68±0.70(Predicted)
form :Solid
color :Pale Yellow to Beige
InChIKey :DUYJMQONPNNFPI-UHFFFAOYSA-N
SMILES :CN1C2=CC=CC=C2C(C2C=CN=C(NC3C=C(NC(=O)C=C)C(N(C)CCN(C)C)=CC=3OC)N=2)=C1
CAS DataBase Reference :1421373-65-0

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

AZD-9291 (Mesylate), also known as Osimertinib, belongs to a third-generation EGFR (epidermal growth factor receptor) inhibitor. It can be used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) in case when the cancer cells carry specific mutations (such as T790M) in the epidermal growth factor receptor. It takes effect through directly binding to the certain mutant forms of EGFR (T790M, L858R, and exon 19 deletions) that are frequently found in NSCLC, further causing poor prognosis for late-stage disease. Since it spares wild type EGFR during therapy, it has only limited toxicity.

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Suppliers and manufacturers

Shanghai Prescrina Pharmaceutical Technology Co., LTD Cangzhou Enke Pharma-tech Co., Ltd. TargetMol Chemicals Inc. Scinova Biotech(Guangzhou) Co., Ltd. TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. Shanghai Boyle Chemical Co., Ltd. Chembest Research Laboratories Limited Beijing HwrkChemical Technology Co., Ltd Beijing Ouhe Technology Co., Ltd Tetranov Biopharm