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ChemicalBook >> CAS DataBase List >> Axitinib

Axitinib

Axitinib price.
  • $39 - $1154
  • Product name: Axitinib
  • CAS: 319460-85-0
  • MF: C22H18N4OS
  • MW: 386.47
  • EINECS:638-771-6
  • MDL Number:MFCD09837898
  • Synonyms:N-METHYL-2-{[3-((E)-2-PYRIDIN-2-YLVINYL)-1H-INDAZOL-6-YL]SULFANYL}BENZAMIDE;AVERMECTINB;Axitinib for research;AG 013736;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]thio]-;Axtinib;N-Methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzaMide;10MG/50MG/100G
45 prices
Selected condition:
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Arctom
  • AvaChem
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • Chemcia Scientific
  • Chemenu
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • Tocris
  • Usbiological
Package
  • 10MG
  • 20mg
  • 50mg
  • 5mg
  • 50
  • 10
  • 100mg
  • 10mM(in 1mL DMSO)
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • ManufacturerAK Scientific
  • Product numberJ11463
  • Product descriptionAxitinib
  • Packaging100mg
  • Price$156
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberA819
  • Product descriptionAxitinib
  • Packaging250mg
  • Price$187
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberJ99425
  • Product descriptionAxitinib
  • Packaging1g
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024707
  • Product descriptionAXITINIB 95.00%
  • Packaging10MG
  • Price$779.63
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0024707
  • Product descriptionAXITINIB 95.00%
  • Packaging1G
  • Price$854.7
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8370
  • Product descriptionAxitinib(AG013736)
  • Packaging50mg
  • Price$50
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8370
  • Product descriptionAxitinib(AG013736)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA8370
  • Product descriptionAxitinib(AG013736)
  • Packaging100mg
  • Price$85
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60145
  • Product descriptionAxitinib
  • Packaging20mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS484876
  • Product description(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98%
  • Packaging100mg
  • Price$105
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS484876
  • Product description(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98%
  • Packaging250mg
  • Price$138
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS484876
  • Product description(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98%
  • Packaging1g
  • Price$355
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberAS484876
  • Product description(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98%
  • Packaging5g
  • Price$1154
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2431
  • Product descriptionAxitinib
  • Packaging10mg
  • Price$39
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2431
  • Product descriptionAxitinib
  • Packaging100mg
  • Price$69
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number2431
  • Product descriptionAxitinib
  • Packaging1g
  • Price$375
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J11463 Axitinib 100mg $156 2021-12-16 Buy
AK Scientific A819 Axitinib 250mg $187 2021-12-16 Buy
AK Scientific J99425 Axitinib 1g $360 2021-12-16 Buy
American Custom Chemicals Corporation API0024707 AXITINIB 95.00% 10MG $779.63 2021-12-16 Buy
American Custom Chemicals Corporation API0024707 AXITINIB 95.00% 1G $854.7 2021-12-16 Buy
ApexBio Technology A8370 Axitinib(AG013736) 50mg $50 2021-12-16 Buy
ApexBio Technology A8370 Axitinib(AG013736) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology A8370 Axitinib(AG013736) 100mg $85 2021-12-16 Buy
Arctom CFN60145 Axitinib 20mg $70 2021-12-16 Buy
Arctom AS484876 (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98% 100mg $105 2021-12-16 Buy
Arctom AS484876 (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98% 250mg $138 2021-12-16 Buy
Arctom AS484876 (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98% 1g $355 2021-12-16 Buy
Arctom AS484876 (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)thio)benzamide ≥98% 5g $1154 2021-12-16 Buy
AvaChem 2431 Axitinib 10mg $39 2021-12-16 Buy
AvaChem 2431 Axitinib 100mg $69 2021-12-16 Buy
AvaChem 2431 Axitinib 1g $375 2021-12-16 Buy

Properties

Melting point :213-215°C
Boiling point :668.9±55.0 °C(Predicted)
Density :1.4
storage temp. :room temp
solubility :DMSO: ≥8mg/mL
form :powder
pka :12.70±0.40(Predicted)
color :white to tan
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey :RITAVMQDGBJQJZ-FMIVXFBMSA-N
CAS DataBase Reference :319460-85-0(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.

Description

Axitinib is a tyrosine kinase inhibitor that blocks the activation of VEGFR1, VEGFR2, VEGFR3, c-kit, and PDGFR-β (IC50 = 1.2, 0.25, 0.29, 1.7, and 1.6 nM, respectively). Through its effects on VEGFRs, it causes regression of fenestrated, VEGFR-rich capillaries in tumors and normal tissue of mice, which is reversed following removal of the inhibitor. Axitinib has shown promise as a therapeutic, in certain cancers and cancer models.

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