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Cas:5680-79-5
ProductName:Methyl Glycinate Hydrochloride
Purity: 99% | Package: 10 kg,25kg and 1 MT
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| Company Name: |
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| Tel: |
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| Email: |
niraj@zephyrsynthesis.com |
| Products Intro: |
Cas:5680-79-5
ProductName:Methyl glycinate hydrochloride
Purity: 99% | Package: 1 kg,5 kg, 10 kg,25kg and 1 MT
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- methyl glycinate
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- $15.00 / 1KG
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2021-07-02
- CAS:616-34-2
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- methyl glycinate
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- $100.00 / 1KG
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2019-07-06
- CAS:616-34-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Customized
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| | Methyl Glycinate Hydrochloride Basic information |
| | Methyl Glycinate Hydrochloride Chemical Properties |
| Melting point | 175 °C (dec.)(lit.) | | density | 1.000 | | storage temp. | Inert atmosphere,Room Temperature | | solubility | >1000 g/L (20°C) | | form | Powder or Cyrstals | | color | White | | Water Solubility | >1000 g/L (20 ºC) | | Sensitive | Hygroscopic | | BRN | 3593644 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChI | InChI=1S/C3H7NO2.ClH/c1-6-3(5)2-4;/h2,4H2,1H3;1H | | InChIKey | COQRGFWWJBEXRC-UHFFFAOYSA-N | | SMILES | C(=O)(OC)CN.Cl | | CAS DataBase Reference | 5680-79-5(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29224995 |
| | Methyl Glycinate Hydrochloride Usage And Synthesis |
| Chemical Properties | Crystalline | | Uses | A Glycine ester, a non-essential amino acid for human development. | | Uses | Glycine methyl ester hydrochloride a non-essential amino acid used for human development. | | reaction suitability | reaction type: solution phase peptide synthesis | | Synthesis | (2) Preparation of glycine methyl ester hydrochloride: 60 mL of methanol was added to a 100 mL round-bottomed flask under ice-bath conditions, followed by the slow dropwise addition of 4 mL of sulfoxide chloride (SOCl2) through a constant-pressure dropping funnel (with a drying tube on top). The resulting off-gas was absorbed using NaOH solution. After stirring the reaction mixture for 1 h, 8 mmol of glycine was added and stirring was continued for 30 min at room temperature. Subsequently, the reaction system was warmed up to 66 °C and refluxed for 6 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) using 2% ninhydrin ethanol solution as a color developer until the disappearance of the raw material spot. After completion of the reaction, the solvent was removed by evaporation to give glycine methyl ester hydrochloride in 100% yield. | | Purification Methods | Crystallise the ester salt from MeOH. [Werbin & Spoerri J Am Chem Soc 69 1682 1947, Beilstein 4 H 340, 4 III 1116.] | | References | [1] Synthetic Communications, 1998, vol. 28, # 3, p. 471 - 474
[2] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[3] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788
[4] Patent: US2014/206741, 2014, A1. Location in patent: Paragraph 0131
[5] European Journal of Organic Chemistry, 2017, vol. 2017, # 3, p. 695 - 703 |
| | Methyl Glycinate Hydrochloride Preparation Products And Raw materials |
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