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Mitotan

Mitotan Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:2,4'-Dichlorodiphenyldichloroethane
CAS:53-19-0
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Mitotan
CAS:53-19-0
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:53-19-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Mitotan
CAS:53-19-0
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:53-19-0
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG

Lastest Price from Mitotan manufacturers

  • Mitotan
  • US $1.00 / KG
  • 2019-05-13
  • CAS: 53-19-0
  • Min. Order: 1G
  • Purity: 98%
  • Supply Ability: 100KG
Mitotan Basic information
Pharmacological effects Chemical Properties Uses Production method Category Toxicity grading Acute toxicity Flammability and hazard properties Storage characteristics Extinguishing media
Product Name:Mitotan
Synonyms:1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-benzen;2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-ethan;2,2-Bis(2-Chlorophenyl-4-chlorophenyl)-1,1-dichloroethane;2,4’-dichlorophenyldichlorethane;2,4'-Dichlorophenyldichlorethane;Benzene, 1-chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]-;Ethane, 1,1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)-;Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-
CAS:53-19-0
MF:C14H10Cl4
MW:320.04
EINECS:200-166-6
Product Categories:API;LYSODREN;Organics;Intermediates & Fine Chemicals;Pharmaceuticals;-
Mol File:53-19-0.mol
Mitotan Structure
Mitotan Chemical Properties
Melting point 77-78 °C(lit.)
Boiling point 405.59°C (rough estimate)
density 1.3118 (rough estimate)
refractive index 1.6000 (estimate)
storage temp. APPROX 4°C
solubility DMSO: soluble20mg/mL, clear
form powder
color white to beige
Water Solubility <0.1 g/100 mL at 24 ºC
Merck 13,6237 / 13,6237
BRN 2056007
CAS DataBase Reference53-19-0(CAS DataBase Reference)
NIST Chemistry ReferenceMitotane(53-19-0)
EPA Substance Registry SystemBenzene, 1-chloro-2-[2,2-dichloro-1-( 4-chlorophenyl)ethyl]-(53-19-0)
Safety Information
Hazard Codes Xn
Risk Statements 40
Safety Statements 36/37
RIDADR 3249
WGK Germany 3
RTECS KH7880000
HazardClass 6.1(b)
PackingGroup III
Hazardous Substances Data53-19-0(Hazardous Substances Data)
MSDS Information
Mitotan Usage And Synthesis
Pharmacological effectsMitotan is structurally similar with insecticide DDT and DDD and can selectively cause the atrophy and necrosis of adrenal cortex-zona fasciculata and reticularis cells but without affecting the zona, therefore the secretion of aldosterone will not affected. After the drug administration, the cortisol and its metabolites level in blood and urine decreased rapidly after treatment. At the same time, the in vivo adrenocorticotropic hormone and metabolite products level also decrease rapidly. It is suitable for the treatment of inoperable, functional and non-functional adrenal cortical carcinoma, adrenal tumor, adrenal hyperplasia-caused Klinefelter’s syndrome, adrenal hyperplasia, and the adjuvant therapy of postoperation cortical cancer and tumor-induced Cushing's syndrome.
After oral administration, about 40% of Mitotan is absorbed through the gastrointestinal tract with the remaining 60% of the prototype excreted together with the feces. At a dose of 5~10 g daily, the plasma concentration can be up to 10~90μg/ml, the concentration of metabolites can be up to 30~50μg/ml. At 6-9 weeks after discontinuation, it can be still detected of o-alkyl chloride in the plasma. Mitotan has a high fat-solubility and is mainly stored in fat. The water soluble metabolites discharged from the urine can account for about 25% of the administered dose.
The above information is edited by the chemicalbook of Dai Xiongfeng.
Chemical PropertiesIt appears as white crystals with the melting point being 76-78 ℃. It is soluble in ethanol and carbon tetrachloride.
UsesIt belongs to antineoplastic agents and can be used for the treatment of adrenal cortical carcinoma.
Production methodIt can be prepared from O-bromo-chlorobenzene (see 05820) by the following steps.
CategoryToxic substances.
Toxicity gradingPoisoning.
Acute toxicityOral-rat; LD50> 5000 mg/kg; Oral-Mouse LD50> 4000 mg/kg.
Flammability and hazard propertiesThermal decomposition can release toxic chloride fume.
Storage characteristicsLow-temperature, dry and ventilated warehouse.
Extinguishing mediaWater, carbon dioxide, foam, powder.
Chemical PropertiesCrystalline Solid
Usesinsecticide, antineoplastic
Usesaminobiphoshphanate for treatment of osteoporosis and Paget's bone disease
UsesMitotane is an inhibitor of steroidogenesis that suppresses the growth of adrenocortical cells. It blocks the expression of several genes that encode proteins involved in steroidogenesis and disrupts mitochondrial respiratory chain activity in human adrenocortical cells. Mitotane has anti-neoplastic actions, alone or in combination with other compounds, and suppresses cortisol synthesis, although it also has significant toxicity in the gastrointestinal tract and nervous system. It is effective against adrenocortical carcinoma and Cushing’s Syndrome in clinical trials.
UsesAn Antineoplastic. Used as an adrenolytic agent
Brand nameLysodren (Bristol-Myers Squibb).
General DescriptionColorless powder.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileMitotan dehydrohalogenates with strong alkalis. Simple aromatic halogenated organic compounds are very unreactive; halogenated aliphatic compounds are moderately or very reactive. For both subgroups, reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Fire HazardFlash point data for Mitotan are not available. Mitotan is probably combustible.
Purification MethodsPurify Mitotane by recrystallisation from pentane, MeOH or EtOH. It is soluble in isooctane and CCl4. [Haller et al. J Am Chem Soc 67 1600 1945, Beilstein 5 IV 1883.]
Mitotan Preparation Products And Raw materials
Raw materials2-Bromochlorobenzene
Tag:Mitotan(53-19-0) Related Product Information
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