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Iopanoic acid

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Tel: 0371-55170695
Products Intro: CAS:96-83-3
Purity:0.99 Package:25KG;5KG;1KG;500G
Tel: 86-18523575427
Products Intro: Product Name:iopanoic acid
Purity:99% Package:1kg
Company Name: career henan chemical co
Tel: 0086-371-86658258
Products Intro: Product Name:Iopanoic acidv
Purity:>=98% Package:1KG;9.8USD
Company Name: Zhuozhou Wenxi import and Export Co., Ltd
Tel: +8613111626072 (WhatsApp)
Products Intro: Product Name:Iopanoic acid
Purity:99%+ HPLC Package:1KG;15USD|100KG;12USD|1000KG;10USD
Company Name: Target Molecule Corp
Tel: 781-999-5354
Products Intro: Product Name:Iopanoic acid;Acidum iopanoicum;Iodopanoic acid;Iodopanoic acid
Purity:95.00% Package:100 mg;200 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

Lastest Price from Iopanoic acid manufacturers

  • Iopanoic acid
  • US $350.00 / KG
  • 2021-10-20
  • CAS:96-83-3
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 9000kg/per week
  • Iopanoic acid
  • US $15.00-10.00 / KG
  • 2021-08-12
  • CAS:96-83-3
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Iopanoic acid Basic information
Product Name:Iopanoic acid
Product Categories:PREVACID
Mol File:96-83-3.mol
Iopanoic acid Structure
Iopanoic acid Chemical Properties
Melting point 153 °C
Boiling point 529.1±50.0 °C(Predicted)
density 2.2567 (estimate)
storage temp. 2-8°C
pka4.8(at 25℃)
form neat
Water Solubility 348.3mg/L(37 ºC)
Merck 14,5058
CAS DataBase Reference96-83-3(CAS DataBase Reference)
EPA Substance Registry SystemBenzenepropanoic acid, 3-amino-.alpha.-ethyl-2,4,6-triiodo- (96-83-3)
Safety Information
Risk Statements 20/21/22
Safety Statements 22-26-36/37/39
WGK Germany 1
RTECS NW5075000
Hazardous Substances Data96-83-3(Hazardous Substances Data)
MSDS Information
Iopanoic acid Usage And Synthesis
Chemical PropertiesLight Brown Solid
UsesIodopanoic Acid is an iodine-containing radiocontrast medium used in cholecystography. Iodopanoic Acid is a potent inhibitor of thyroid hormone release from thyroid gland.
Manufacturing Process(A) Preparation of α-Ethyl-m-Nitrocinnamic Acid: This acid is prepared from 100 g of m-nitrobenzaldehyde, 210 g of butyric anhydride and 73 g of sodium butyrate. The crude α-ethyl-m-nitrocinnamicacid is crystallized from ethanol giving about 105 g, MP 140° to 142°C. From the filtrates there may be isolated a small amount of a stereoisomer, which when pure melts at 105° to 106°C.
(B) Preparation of m-Amino-α-Ethylhydrocinnamic Acid: A mixture of 50 g of α-ethyl-m-nitrocinnamic acid, 9.1 g of sodium hydroxide, 600 cc of water and 5 teaspoons of Raney nickel catalyst is shaken at 32°C in an atmosphere ofhydrogen at an initial pressure of 450 psi until the calculated amount of hydrogen is absorbed. The filtered solution is acidified with hydrochloric acid, made basic with ammonium hydroxide and again acidified with acetic acid. Upon concentration of this solution, an oil separates which crystallizes upon standing, giving about 20 g, MP 60° to 68°C. Complete evaporation of the filtrate and extraction of the residue of inorganic salts with ether gives about 20 g of additional material, MP 54° to 59°C. Recrystallization of the combined product from benzene petroleum ether gives about 35 g of m-amino-α- ethylhydrocinnamic acid, MP 67° to 70°C.
(C) Preparation of β-(3-Amino-2,4,6-Triiodophenyll-α-Ethylpropionic Acid: A solution of 5.0 g of m-amino-α-ethylhydrocinnamic acid in 100 cc of water containing 5 cc of concentrated hydrochloric acid is added over a period of ? hour to a stirred solution of 3.2 cc of iodine monochloride in 25 cc of water and 25 cc of concentrated hydrochloric acid heated to 60°C. After addition is complete, the heating is continued for one hour longer at 60° to 70°C. A black oil separates which gradually solidifies.
The mixture is then cooled and sodium bisulfite added to decolorize. Recrystallization of the product from methanol gives about 8 g, MP 147° to 150°C. The β-(3-amino-2,4,6-triiodophenyl)-α-ethylpropionic acid may be purified further by precipitation of the morpholine salt from ether solution and regeneration of the free amino acid by treatment of a methanol solution of the morpholine salt with sulfur dioxide. The pure amino acid has the MP 155° to 156.5°C.
Therapeutic FunctionDiagnostic aid (radiopaque medium)
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