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Teneligliptin

Teneligliptin Suppliers list
Company Name: ChemExpress
Tel: +86-021-58950125 +86-021-58950125;
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Products Intro: Product Name:Teneligliptin
CAS:760937-92-6
Purity:99% Package:100g;1kg;10kg
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:Teneligliptin
CAS:760937-92-6
Purity:98% Min. Package:1G;1KG;100KG
Company Name: Anqing Chico Pharmaceutical Co., Ltd.
Tel: 15380796838
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Products Intro: Product Name:Teneligliptin
CAS:760937-92-6
Purity:99% Package:10g;100g;1kg; 25kg or More
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
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Products Intro: Product Name:Teneligliptin
CAS:760937-92-6
Purity:99% Package:1KG;1000USD
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 18871490254
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Products Intro: Product Name:[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
CAS:760937-92-6
Purity:0.99 Package:5KG;1KG Remarks:C22H30N6OS

Teneligliptin manufacturers

  • Teneligliptin
  • Teneligliptin pictures
  • $0.00/ kg
  • 2024-09-14
  • CAS:760937-92-6
  • Min. Order: 1kg
  • Purity: 99%, Single impurity<0.1
  • Supply Ability: 1 ton
  • Teneligliptin
  • Teneligliptin pictures
  • $0.00 / 1KG
  • 2022-09-16
  • CAS:760937-92-6
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton
  • Teneligliptin
  • Teneligliptin pictures
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:760937-92-6
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
Teneligliptin Basic information
Product Name:Teneligliptin
Synonyms:teneligliptin;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;Teneligptin WS;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;API (Teneligliptin free base);Teliglietin;Teneligliptin (MP-513)
CAS:760937-92-6
MF:C22H30N6OS
MW:426.58
EINECS:
Product Categories:
Mol File:760937-92-6.mol
Teneligliptin Structure
Teneligliptin Chemical Properties
Melting point >100°C (dec.)
Boiling point 663.4±55.0 °C(Predicted)
density 1.38
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka8.70±0.10(Predicted)
color Off-White
InChIKeyWGRQANOPCQRCME-PMACEKPBSA-N
SMILESC([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O
Safety Information
MSDS Information
Teneligliptin Usage And Synthesis
DescriptionTeneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC50=0.37 nM).
OriginatorMitsubishi Tanabe Pharma (Japan)
UsesTeneligliptin, is a dipeptidyl peptidase-4 (DPP-4) inhibitor that is used to treat type 2 diabetes. It is eliminated via excretion, and has a half-life of 24.2 hours in the human body.
DefinitionChEBI: Teneligliptin is an amino acid amide.
Brand nameTenelia
PharmacokineticsReported evidence suggests that with teneligliptin 20 mg therapy, Tmax was 1 hour, and t1/2 was 18.9 hours. Maximum (89.7%) inhibition in plasma DPP-4 activity was noted within 2 hours and maintained >60% at 24 hours. Compared to the placebo, active plasma GLP-1 concentration was higher throughout the day and even 24 hours after administration of 20 mg of teneligliptin. Metabolism of teneligliptin was majorly mediated through CYP3A4, a cytochrome P450 isozyme, and flavin-containing monooxygenases (FMO1 and FMO3). A weak inhibitory activity of teneligliptin on CYP2D6, CYP3A4, and FMO was noted, while there was no inhibitory activity on CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C8/9, CYP2C19, and CYP2E1. There was no induction of expression of CYP1A2 or CYP3A4. Reported evidence suggests that teneligliptin is metabolized and eliminated via renal and hepatic routes. Approximately 34% of teneligliptin is excreted unchanged via the renal route, while 66% is metabolized and eliminated via the hepatic and renal routes[1].
Side effects The DPP-4 molecule in teneligliptin reduces the risk of hypoglycemia, although it is possible. These are some of teneligliptin’s major and minor side effects:
Hypoglycemia
Headache
Upper respiratory tract infection
Gastrointestinal symptoms
Constipation
Fatigue
Kidney problems
Nasopharyngitis
Skin rashes
Itching
Loss of appetite
Abdominal pain
References[1] Surendra Kumar Sharma. “Teneligliptin in management of type 2 diabetes mellitus.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 9 (2016): 251–60.
Teneligliptin Preparation Products And Raw materials
Tag:Teneligliptin(760937-92-6) Related Product Information
N-Methyl-2-pyrrolidone Tribenuron methyl Pyrrolidine PHENYL VALERATE Methyl salicylate Methanol Methyl acrylate 1-Pyrrolidinecarboxylic acid, 4-oxo-2-(3-thiazolidinylcarbonyl)-, 1,1-diMethylethyl ester, (2R)- VILAZODONE Rivaroxaban Pioglitazone hydrochloride Pyrrole N-Aminoethylpiperazine Polyvinylpyrrolidone Basic Violet 1 Kresoxim-methyl (2S,4R)-Teneligliptin Methylparaben