| Company Name: |
Cipla Ltd
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| Tel: |
+912224826000 |
| Email: |
exports@cipla.com |
| Products Intro: |
Product Name:Glatiramer
CAS:28704-27-0
Purity:98% Package:1 kg,5 kg, 10 kg,25kg And 1MT
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| Company Name: |
Nanjing Peptide Biotech Ltd.
|
| Tel: |
025-025-58361106-805-805 13082558573 |
| Email: |
liugang@njpeptide.com |
| Products Intro: |
Product Name:Glatiramer
CAS:28704-27-0
Purity:90%HPLC,95%HPLC,98%HPLC Package:5mg,20mg,100mg,250mg,500mg,1g
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| Product Name: | COP-1 | | Synonyms: | [L-ALA, L-GLU, L-LYS HBR, L-TYR]N;COP-1;POLY(ALA, GLU, LYS, TYR) HYDROBROMIDE;(t,g)-a-l;poly(ala;POLY(ALA, GLU, LYS, TYR) 6:2:5:1*HYDROBR OMIDE MOL.;Copaxone;(l-ala, l-glu, l-lys, l-tyr)n ·hbr | | CAS: | 28704-27-0 | | MF: | C23H41N5O11 | | MW: | 563.61 | | EINECS: | | | Product Categories: | | | Mol File: | 28704-27-0.mol |  |
| | COP-1 Chemical Properties |
| | COP-1 Usage And Synthesis |
| Description | Copaxone was launched in Israel and the US for treatment of relapsingremitting
multiple sclerosis. The amino acid polymer is prepared from the Ncarboxyanhydrides
of Tyr, Ala, γ-benzylglutamate and ε,N-trifluoroacetyllysine followed
by deprotection. Structurally, the random polymer, with a residue molar ratio of
6.0:1.9:4.7:1.O=Ala:Glu:Lys:Tyr, simulates myelin basic protein (MBP). This gives it
immunomodulating and immunosuppressive activity (antigen specific so not a general
immunosuppressive). The mechanism involves binding to MHC class Ⅱ (I-A/DR)
molecules which results both in competition with myelin antigens for T-cell activation
and in induction of specific suppressor cells of the Th2 type. Therefore, the antigenspecific
interaction gives rise to a reduced probability of long-term damage to the
immune system. The competition with MBP and other myelin-associated antigens
inhibits T-cell responses to MBP, and the binding occurs with high efficiency, fast rates
and is non-species specific. It resulted in a 29% reduction in relapse rate and is most
effective in patients with less accumulated neurologic disability. | | Originator | Yeda (Israel) | | Brand name | Copaxone |
| | COP-1 Preparation Products And Raw materials |
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