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| | 1-(4-Bromophenyl)ethanol Basic information | | Synthesis |
| | 1-(4-Bromophenyl)ethanol Chemical Properties |
| Melting point | 36-38 °C(lit.) | | Boiling point | 119-121 °C7 mm Hg(lit.) | | density | 1.46 g/mL at 25 °C(lit.) | | refractive index | 1.5680 | | Fp | 146 °F | | storage temp. | Store at room temperature | | pka | 14.22±0.20(Predicted) | | form | Crystalline Powder | | Specific Gravity | 1.460 | | color | White to light brown | | BRN | 2042029 | | InChI | 1S/C8H9BrO/c1-6(10)7-2-4-8(9)5-3-7/h2-6,10H,1H3 | | InChIKey | XTDTYSBVMBQIBT-UHFFFAOYSA-N | | SMILES | CC(O)c1ccc(Br)cc1 | | CAS DataBase Reference | 5391-88-8(CAS DataBase Reference) | | NIST Chemistry Reference | Benzenemethanol, 4-bromo-«alpha»-methyl-(5391-88-8) |
| Hazard Codes | Xn,Xi | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HS Code | 29062900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-(4-Bromophenyl)ethanol Usage And Synthesis |
| Synthesis | There are many ways to prepare 1-(4-Bromophenyl)ethanol. It can be prepared by reducing 1-(4-bromophenyl)-1-ethyl ketone or 1-(4-bromophenyl)-1-acetic acid with sodium borohydride; or by reacting p-bromobenzyl chloride with sodium acetate in glacial acetic acid to produce p-bromobenzyl acetate, and then by alkaline hydrolysis of p-bromobenzyl acetate to obtain 1-(4-Bromophenyl)ethanol. In this paper, p-bromobenzaldehyde is used as the starting material, and 1-(4-Bromophenyl)ethanol is prepared by reacting it with chloroform with dimethylformamide (DMF) as solvent under the catalysis of potassium hydroxide/methanol. The reaction conditions of this process route are optimized [1]. The synthetic reaction formula for 1-(4-Bromophenyl)ethanol is shown in the figure below: 
| | Chemical Properties | white to light brown crystalline powder | | Uses | 4-Bromo-α-methylbenzyl alcohol was used in the synthesis of 3-(4-(1-(tert-butyl)dimethylsilyloxy)ethyl)phenyl)-3-(trifluoromethyl)-3H-diazirine and (1-(4-bromophenyl)ethoxy)(tert-butyl)dimethylsilane. | | Purification Methods | The (±)-racemate is purified by distillation in a vacuum (b 90o/1mm, 119-121o/7mm, d 1.46) and it solidifies on cooling (m 36-37o) [Overberger et al. Org Synth |
| | 1-(4-Bromophenyl)ethanol Preparation Products And Raw materials |
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