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Mitoxantrone hydrochloride

Mitoxantrone hydrochloride Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Mitoxantrone hydrochloride
CAS:70476-82-3
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Beijing Cooperate Pharmaceutical Co.,Ltd.
Tel: +86-10-60279497 +86(0)15646567669
Email: sales01@cooperate-pharm.com
Products Intro: Product Name:Mitoxantrone HCl
CAS:70476-82-3
Purity:98% Package:100G;1KG;5KG;10KG;25KG;50KG;100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:70476-82-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Mitoxantrone hydrochloride
CAS:70476-82-3
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;product@chemlin.com.cn
Email: product@chemlin.com.cn
Products Intro: CAS:70476-82-3
Purity:98% Package:g-Kg Remarks:Dark blue powder

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Mitoxantrone hydrochloride Basic information
Product Name:Mitoxantrone hydrochloride
Synonyms:1,4-dihydroxy-5,8-bis(2-(2-hydroxyethylamino)ethylamino)anthracene-9,10-dione dihydrochloride;Mitoxantrone hydrochloride 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride;Mitoxantrone dihydrochloride, >=99%;DHAQ;DHAQ DIHYDROCHLORIDE;1,4-DIHYDROXY-5,8-BIS[2-[(2-HYDROXYETHYL)AMINO]ETHYL]AMINO]-9,10-ANTHRACENEDIONE DIHYDROCHLORIDE;1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]anthraquinone dihydrochloride;novantrone
CAS:70476-82-3
MF:C22H30Cl2N4O6
MW:517.4028
EINECS:274-619-1
Product Categories:API;NOVALDIN;API's;Anti-cancer&immunity
Mol File:70476-82-3.mol
Mitoxantrone hydrochloride Structure
Mitoxantrone hydrochloride Chemical Properties
Melting point 203-205 C
solubility Sparingly soluble in water, slightly soluble in methanol, practically insoluble in acetone.
form neat
Water Solubility Soluble to 5 mM in water and to 75 mM in DMSO
InChIKeyZAHQPTJLOCWVPG-UHFFFAOYSA-N
CAS DataBase Reference70476-82-3(CAS DataBase Reference)
EPA Substance Registry System9,10-Anthracenedione, 1,4-dihydroxy-5,8-bis[[2-[( 2-hydroxyethyl)amino]ethyl] amino]-, dihydrochloride(70476-82-3)
Safety Information
Hazard Codes T,T+
Risk Statements 46-61-26/27/28
Safety Statements 53-36/37/39-45-22
RIDADR 3249
WGK Germany 3
RTECS CB5748500
HazardClass 6.1(b)
PackingGroup III
HS Code 29146100
Hazardous Substances Data70476-82-3(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
Mitoxantrone hydrochloride Usage And Synthesis
DescriptionMitoxantrone hydrochloride is the first of the synthetic anthracenediones related to doxorubicin to reach the marketplace. Mitoxantrone is useful in the treatment of advanced localized and metastatic mammary carcinomas. It is reported to be less cardiotoxic than doxorubicin.
Chemical PropertiesDark blue, electrostatic, hygroscopic powder.
OriginatorLederle (USA)
Usesanalgesic, antipyretic
Brand nameNovantrone (Serono).
General DescriptionMitoxantrone is supplied as a blue aqueous solution in 10-and 20-mg vials for IV administration in the treatment of acute lymphoid leukemia, acute myeloid leukemia, breastcancer, prostate cancer, non-Hodgkin’s lymphoma, andmultiple sclerosis. The mechanisms of resistance are thesame as those seen for the anthracyclines. The distributionhalf-life is 1.1 to 3.1 hours, and the drug has a large volumeof distribution (11 L/kg). The elimination half-life rangedfrom 23 to 215 hours, and elimination was primarily via thebile. Metabolism of the agent involves oxidation of the sidechainalcohols to give the monocarboxylic and dicarboxylicacids.Other toxicities are those seen for the anthracyclinesand include myelosuppression, nausea, vomiting, mucositis,diarrhea, and alopecia. The intense color of the parent drugand metabolites may turn the urine blue.
Mitoxantrone hydrochloride Preparation Products And Raw materials
Tag:Mitoxantrone hydrochloride(70476-82-3) Related Product Information
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