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Flunixin meglumine

Flunixin meglumine Suppliers list
Company Name: Wuhan Fortuna Chemical Co., Ltd
Tel: +86-27-59207850 +86-13986145403
Email: info@fortunachem.com
Products Intro: Product Name:Flunixin meglumine
CAS:42461-84-7
Purity:99%-101%; USP Package:25Kg/Drum
Company Name: Capot Chemical Co.,Ltd.
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Email: sales@capotchem.com
Products Intro: Product Name:2-[[2-Methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic acid meglumine salt
CAS:42461-84-7
Purity:97% (Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
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Products Intro: Product Name:Flunixin Meglumine (300 mg)
CAS:42461-84-7
Purity:99% Package:25KG;5KG;1KG
Company Name: Hubei XinRunde Chemical Co., Ltd.
Tel: +8615102730682
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Products Intro: Product Name:Flunixin Meglumine
CAS:42461-84-7
Purity:99% Package:1KG;10USD
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Products Intro: Product Name:Flunixin meglumin
CAS:42461-84-7
Purity:98% Package:1KG;1USD

Flunixin meglumine manufacturers

  • Flunixin meglumine
  • $20.00 / 1kg
  • 2023-01-31
  • CAS:42461-84-7
  • Min. Order: 10kg
  • Purity: 99%
  • Supply Ability: 20tons
  • Flunixin meglumin
  • $10.50 / 1KG
  • 2023-01-30
  • CAS:42461-84-7
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1 ton
  • Flunixin meglumine
  • $0.00 / 1KG
  • 2023-01-28
  • CAS:42461-84-7
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
Flunixin meglumine Basic information
Product Name:Flunixin meglumine
Synonyms:2-[[2-methyl-3-(trifluoromethyl)phenyl]amino]-3-pyridinecarboxylate, 1-deoxy-1-(methylamino)-D-glucitol(1:1);Flunixin Solution, 100ppm;Flunixin Meglumine injectable grade;flunixinn-methylglucanine;ino)-3-pyridinecarboxylate(salt);BANAMINE;FLUNIXINE MEGLUMINE SALT;FLUNIXIN MEGLUMINE SALT
CAS:42461-84-7
MF:C21H28F3N3O7
MW:491.46
EINECS:255-836-0
Product Categories:Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;API;veterinary drugs
Mol File:42461-84-7.mol
Flunixin meglumine Structure
Flunixin meglumine Chemical Properties
Melting point 136.6-137.4 °C
alpha -9~-12゜(D/20℃)(c=12,CH3OH)
storage temp. room temp
solubility H2O: freely soluble
form solid
color off-white
Water Solubility soluble
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR UN 2811 6.1 / PGI
WGK Germany 3
RTECS LZ4367000
HS Code 29339900
MSDS Information
ProviderLanguage
SigmaAldrich English
Flunixin meglumine Usage And Synthesis
Chemical PropertiesWhite Solid
Usesdental carries prophylactic
UsesCyclooxigenase inhibitor. Anti-inflammatory; analgesic; antipyretic.
UsesFlunixin meglumine has been used as a nonsteroidal anti-inflammatory drug standard in electrospray ionization mass spectrometry (LC-ESI/MS).
DefinitionChEBI: An organoammonium salt obtained by combining flunixin with one molar equivalent of 1-deoxy-1-(methylamino)-D-glucitol. A relatively potent non-narcotic, nonsteroidal analgesic with anti-inflammatory, anti-endotoxic and anti-pyretic propert es; used in veterinary medicine for treatment of horses, cattle and pigs.
Brand nameBanamine Veterinary (Schering-Plough Animal Health).
General DescriptionFlunixin meglumine is a nonsteroidal anti-inflammatory drug and a potent cyclo-oxygenase (COX) inhibitor. It is commonly used as an analgesic and antipyretic in animals.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Biological Activityflunixin meglumine serves as a non-narcotic and non-steroidal analgesic agent with antipyretic activities. as a potent inhibitor of the enzyme cyclooxygenase, flunixin meglumine has demonstrated a wide-spectrum of biological activities including anti-inflammation and pain-alleviating. moreover, flunixin meglumine could be applied as a drug in animals for the management of intestinal ischaemia, colic, and endotoxemia. [1]
Biochem/physiol ActionsCOX1, COX2 and PLA2 inhibitor non-narcotic analgesic, anti-pyretic, anti-inflammatory.
Veterinary Drugs and TreatmentsIn the United States, flunixin meglumine is approved for use in horses, cattle and swine; however, it is approved for use in dogs in other countries. The approved indications for its use in the horse are for the alleviation of inflammation and pain associated with musculoskeletal disorders and alleviation of visceral pain associated with colic. In cattle it is approved for the control of pyrexia associated with bovine respiratory disease and endotoxemia, and control of inflammation in endotoxemia. In swine, flunixin is approved for use to control pyrexia associated with swine respiratory disease.
Flunixin has been suggested for many other indications in various species, including: Horses: foal diarrheas, shock, colitis, respiratory disease, post-race treatment, and pre- and post ophthalmic and general surgery; Dogs: disk problems, arthritis, heat stroke, diarrhea, shock, ophthalmic inflammatory conditions, pre- and post ophthalmic and general surgery, and treatment of parvovirus infection; Cattle: acute respiratory disease, acute coliform mastitis with endotoxic shock, pain (downer cow), and calf diarrheas; Swine: agalactia/hypogalactia, lameness, and piglet diarrhea. It should be noted that the evidence supporting some of these indications is equivocal and flunixin may not be appropriate for every case.
in vitroan in vitro whole blood model in feedlot calves was adopted to detect the activity of the anti-inflammatory agents flunixin-meglumine (flu), rs (±) carprofen (cpf) and s (+) cpf. the drugs all exhibited inhibitory activity on coxs, with an order of flu > s (+) cpf > rs (±) cpf in their potency. this finding indicated that flu was a nonselective suppressorr of bovine coxs, whereas rs (±) cpf and s (+) cpf selectively inhibited cox-2 isoenzyme. [2]
in vivofindings from mice, rats and monkeys suggested flunixin meglumine as a potent non-narcotic analgesic agent after parenteral administration. after being subcutaneous administered, this agent showed higher efficacy than pentazocine, meperidine and codeine in the rat yeast paw test. intramuscular administration and subcutaneous administration of flunixin meglumine had similar effects. moreover, orally administered flunixin meglumine also exerted analgesic and anti-inflammatory activities. based on mice abdominal constriction test, flunixin meglumine had comparable efficacy to pentazocine and was more potent than meperidine and codeine. in primates, 10 mg/kg flunixin meglumine showed an equal efficacy to that of 0.3 mg/kg morphine. [1]
IC 50a potent cyclooxygenase inhibitor with ic50 values of 1 nm.
references[1]ciofalo vb, latranyi mb, patel jb and taber ri. flunixin meglumine: a non-narcotic analgesic. j pharmacol exp ther. 1977 mar; 200(3): 501-7.
[2]miciletta m, cuniberti b, barbero r and re g. in vitro enantioselective pharmacodynamics of carprofen and flunixin-meglumine in feedlot cattle. j vet pharmacol ther. 2014 feb; 37(1): 43-52.
[3] jochle w, moore jn, brown j, baker gj, lowe je, fubini s, reeves mj, watkins jp and white na. comparison of detomidine, butorphanol, flunixin meglumine and xylazine in clinical cases of equine colic. equine vet j suppl. 1989 jun; (7): 111-6.
Flunixin meglumine Preparation Products And Raw materials
Tag:Flunixin meglumine(42461-84-7) Related Product Information
Methyl acrylate Methylparaben Isosorbide Parathion-methyl Meglumine Bensulfuron methyl Kresoxim-methyl METSULFURON METHYL Thiophanate-methyl FLAVONE HIPPOPHAES FLUNIXIN MEGLUMINE IMP. A (EP): 2-CHLOROPYRIDINE-3-CARBOXYLIC ACID FLUNIXIN MEGLUMINE IMP. C (EP): ETHYL 2-CHLOROPYRIDINE-3-CARBOXYLATE FLUNIXIN MEGLUMINE,FLUNIXIN MEGLUMINE SALT QUINOLINE-3-CARBOXYLIC ACID Methyl NIACINAMIDE USP Flunixin meglumine SILIBININ-N-METHYLGLUCAMINE, 95% (HPLC)