| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Calcineurin
CAS:90371-51-0
Purity:lyophilized powder, main >= 2,500units/mg protein Package:50units, 100units, 500units Remarks:C1907
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Product Name:Calcineurin from bovine brain
CAS:90371-51-0
|
|
| | CALCINEURIN Basic information |
| Product Name: | CALCINEURIN | | Synonyms: | CALCINEURIN FROM BOVINE BRAIN, >10 U/MG;calcium/calmodulin-activated protein phosphatase;MODULATOR BINDING PROTEIN;PP2B;PPASE-2B;PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI;PROTEIN PHOSPHATASE 2B;CAN | | CAS: | 90371-51-0 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![CALCINEURIN Structure]() |
| | CALCINEURIN Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: soluble | | form | lyophilized powder |
| | CALCINEURIN Usage And Synthesis |
| Uses | Calcineurin from bovine brain has been used:
- as a positive control in western blot analysis of oocytes and cumulus cells proteome
- as a positive control in calmodulin (CaM)-agarose binding assay
- to test its phosphatase activity in the presence of okadaic acid
| | General Description | Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain. | | Biochem/physiol Actions | Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells. |
| | CALCINEURIN Preparation Products And Raw materials |
|