- Hispidulin
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- $0.00 / 20mg
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2023-02-24
- CAS:1447-88-7
- Min. Order: 20mg
- Purity: ≥98%(HPLC)
- Supply Ability: 100 g
- HISPIDULIN
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- $6.60 / 1KG
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2019-12-26
- CAS:1447-88-7
- Min. Order: 500g
- Purity: 98%
- Supply Ability: 1kg, 50kg, 100kg
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| | HISPIDULIN Basic information |
| Product Name: | HISPIDULIN | | Synonyms: | SCUTELLAREIN 6-METHYL ETHER;4',5,7-Trihydroxy-6-methoxyflavone;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one;6-Methoxyapigenin;6-Methylscutellarein;Hispidulin(Dinatin);Methoxyapigenin;Dinatin | | CAS: | 1447-88-7 | | MF: | C16H12O6 | | MW: | 300.26 | | EINECS: | | | Product Categories: | Miscellaneous Natural Products | | Mol File: | 1447-88-7.mol |  |
| | HISPIDULIN Chemical Properties |
| Melting point | 291-292 °C | | Boiling point | 601.5±55.0 °C(Predicted) | | density | 1.512±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble20mg/mL, clear | | form | powder | | pka | 6.51±0.40(Predicted) | | color | white to beige |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 | | RTECS | DJ2996000 |
| | HISPIDULIN Usage And Synthesis |
| Uses | Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
| | Definition | ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6. | | General Description | This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | | Biological Activity | Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties. | | Biochem/physiol Actions | Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand. |
| | HISPIDULIN Preparation Products And Raw materials |
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