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Olanzapine Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Olanzapine
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: Product Name:Olanzapine
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070;
Products Intro: Product Name:Olanzapine
Purity:98% Package:For 1kg,USD 1100/kg DDU Remarks:Yellow crystalline powder
Tel: +86 21 5161 9050/ 5187 7795
Products Intro: Product Name:Olanzapine
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Products Intro: Product Name:Olanzapine
Purity:98% Package:1KG;1USD

Lastest Price from Olanzapine manufacturers

  • Olanzapine
  • US $1.00 / KG
  • 2020-01-19
  • CAS:132539-06-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10T
  • Olanzapine
  • US $1.00 / KG
  • 2019-12-31
  • CAS:132539-06-1
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100kg
  • Olanzapine
  • US $0.00-0.00 / KG
  • 2019-12-31
  • CAS: 132539-06-1
  • Min. Order: 1KG
  • Purity: 99.0%+
  • Supply Ability: 60 tons
Olanzapine Basic information
Antipsychotics Chemical properties Uses Production method
Product Name:Olanzapine
Synonyms:2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine, LY-170053, Zyprexa;4-Amino-2-methyl-10H-Thineo(2,3b)(1,5)benzodiazepine HCL;2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-β][1,5]benzodiazepine, LY-170053, Zyprexa;2-Methyl-4-(4-methyl-1-pipemzinyl)-10H-thieno[2,3-b][1,5]benzodiazepine;Larmac;2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine;2-methyl-4-(4-methylpiperazin-1-yl)-;Olanzapine (200 mg)
Product Categories:Active Pharmaceutical Ingredients;APIs;Olanzapine;Intermediates & Fine Chemicals;Pharmaceuticals;Aromatics;API;ZYPREXA;Other APIs;Heterocycles;Sulfur & Selenium Compounds
Mol File:132539-06-1.mol
Olanzapine Structure
Olanzapine Chemical Properties
Melting point 195°C
Boiling point 476.0±55.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
Fp 2℃
storage temp. -20°C Freezer
solubility DMSO: >15mg/mL
form powder
color yellow
Merck 14,6822
BRN 7655141
CAS DataBase Reference132539-06-1(CAS DataBase Reference)
NIST Chemistry ReferenceOlanzapine(132539-06-1)
Safety Information
Hazard Codes Xi,Xn,F
Risk Statements 36/38-36-20/21/22-11
Safety Statements 26-36/37-16
RIDADR UN 2811 6.1 / PGIII
WGK Germany 3
RTECS XJ9007750
HazardClass 6.1
PackingGroup III
HS Code 29349990
Olanzapine Usage And Synthesis
AntipsychoticsOlanzapine also known as olanzapine, olanzapine Oran, is a common antipsychotic drugs, clinically used to control schizophrenia, bipolar mania and agitation symptoms of dementia, it can significantly improve schizophrenia negative (for example: apathy, emotional and social withdrawal, poverty of speech), positive symptoms (such as: delusions, hallucinations, thought disorder, hostility and suspicion), and it may also relieve common secondary schizophrenia and related disorders affective symptoms.
Good oral absorption, it needs 5-8 hours to reach the peak plasma concentration, and it is not affected by eating, it is metabolized in the liver through a combination of oxidation ; the major circulating metabolite is the 10-N-glucuronide.
Animal experiments show that olanzapine displays affinity on multiple receptors 5-HT, dopamine D, α-adrenergic, histamine H et , the affinity with 5-HT2 receptor in vitro and in vivo is greater than its affinity for dopamine D2 receptors.
Animal behavior studies show that olanzapine has a 5-HT, dopamine, and cholinergic antagonism effect, and it is consistent with its receptor binding situation.
Electrophysiological studies show that olanzapine selectively reduces the limbic system (A10) dopaminergic neurons discharge, while the effect on the striatal (A9) motor path function is very small. In the reaction below to produce froze dosage levels, it can reduce the conditioned avoidance response. Different with other antipsychotics, olanzapine increases the anxiolytic response in test .
The above information is edited by the chemicalbook of Tian Ye.
Chemical propertiesCrystallization from acetonitrile, melting point of 195 ℃.
UsesUsed to control schizophrenia, bipolar mania and other diseases
Production method4-amino-2-methyl-10H-thieno [2,3-b] [1,5] benzo-diazepin-hydrochloride and N-methylpiperazine in toluene and dimethylsulfoxide , reflux under nitrogen for 20h, to obtain olanzapine.
DescriptionZyprexa was launched in Canada, Germany, the UK and US as an antipsychotic agent. Prepared in three steps via the intermediate diazepinone, it is an atypical antipsychotic with a high affinity for dopaminergic and serotonergic receptors. Specifically, olazapine is a potent 5-HT2/D2 antagonist with anticholinergic activity. It has a greater antagonistic effect at 5-HT2a than at dopamine D2 receptors and in vivo is clozapine-like. Thus it is less likely to produce extrapyramidal side effects and does not produce any granulocytopenia. Its 10 metabolic products are all inactive.
Chemical PropertiesYellow Crystalline Powder
OriginatorLilly (USA)
UsesA serotonin (5-HT2) and dopamine (D1/D2) receptor antagonist with anticholinergic activity. Antipsychotic.
Usesintermediate for Imidacloprid, Indobufen, Nitroguanidine, Nalorphine, Tazarotene, Trovafloxacin
Usesanti-ulcer, gastrointestinal-emptying agent enhances motility in the upper gastrointestinal tract
DefinitionChEBI: A benzodiazepine that is 10H-thieno[2,3-b][1,5]benzodiazepine substituted by a methyl group at position 2 and a 4-methylpiperazin-1-yl group at position 4.
Brand nameZyprexa (Lilly).
General DescriptionOlanzapine, 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine (Zyprexa), isa yellow crystalline solid that is essentially insoluble in water.Olanzapine orally disintegrating tablets (Zyprexa Zydis) is asolid dosage form that immediately disintegrates when exposedto saliva. This product is useful for elderly patients whohave difficulty in swallowing. An injectable form, olanzapinefor injection (Zyprexa IM), is indicated for agitation associatedwith schizophrenia or bipolar I mania. Olanzapine iscombined with fluoxetine (Symbyax) for use in depressionthat is associated with bipolar I disorder. Peak concentrationsof oral olanzapine are reached at 6 hours after oral administration,and absorption of the compound is not affected byfood.
Olanzapine binds with high affinity at DA D2, 5-HT2A,5-HT2C, 5-HT6,α1, and H1 histamine receptors. The effectsof olanzapine for the treatment of schizophrenia are presumablymediated through antagonism at D2 and 5-HT2Areceptors.The use of olanzapine in acute maniathat is associated with bipolar I disorder is thought to bemediated by antagonism at D2 and other monamine receptors.Additionally, olanzapine is postulated to produce itsmood stabilizing and antidepressant effects through 5-HT2Areceptor blockade and increased cortical DA and NE concentrations.Several studies have investigated the effectof olanzapine-induced weight gain and new-onset type 2diabetes.In a comparison study with risperidone,olanzapine was shown to have a greater risk of producingdyslipidemia and type 2 diabetes.
Olanzapine Preparation Products And Raw materials
Raw materials
Tag:Olanzapine(132539-06-1) Related Product Information
Benzodiazepine OLANZAPINE N-OXIDE 2-Ethyl-4-(4-methyl-1-piperazinyl)-7-nitro-10H-thieno(2,3-b)(1,5)benzo diazepine OLANZAPINE-METHYL-D3 GLUCURONIDE OLANZAPINE-METHYL-D3 OLANZAPINE GLUCURONIDE,Olanzapine-b-D-glucuronide Flumezapine Olanzapine Methyl acetate Methyl 1-Methylpiperazine Methyl salicylate 1,2-DIMETHYLHYDRAZINE DIHYDROCHLORIDE Kresoxim-methyl Thiophanate-methyl Methyl bromide Cephalothin Tribenuron methyl