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| | 4-Methoxy-1-naphthaldehyde Basic information |
| | 4-Methoxy-1-naphthaldehyde Chemical Properties |
| Melting point | 35-36 °C(lit.) | | Boiling point | 212 °C40 mm Hg(lit.) | | density | 1.1879 | | refractive index | 1.6640 | | Fp | >230 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | Low Melting Solid | | color | Slightly beige to pink-brown | | Sensitive | Air Sensitive | | BRN | 2046436 | | InChI | 1S/C12H10O2/c1-14-12-7-6-9(8-13)10-4-2-3-5-11(10)12/h2-8H,1H3 | | InChIKey | MVXMNHYVCLMLDD-UHFFFAOYSA-N | | SMILES | COc1ccc(C=O)c2ccccc12 | | CAS DataBase Reference | 15971-29-6(CAS DataBase Reference) | | NIST Chemistry Reference | 1-Naphthalenecarboxaldehyde, 4-methoxy-(15971-29-6) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29124990 | | Storage Class | 11 - Combustible Solids |
| | 4-Methoxy-1-naphthaldehyde Usage And Synthesis |
| Chemical Properties | slightly beige to pink-brown low melting solid | | Uses | 4-Methoxy-1-naphthaldehyde was used in fluorometric enzymatic assay for determination of activity of class I and II alcohol dehydrogenase isoenzymes in human pancreas and in human liver homogenates. | | Biochem/physiol Actions | 4-Methoxy-1-naphthaldehyde is fluorogenic substrate for human alcohol dehydrogenase (ADH). | | Synthesis | General method: A mixture of 4-hydroxy-1-naphthaldehyde (1 eq.), potassium carbonate (K2CO3, 1.5 eq.) and iodomethane (1.5 eq.) in acetone (12 mL/mmol) was stirred under reflux conditions for 4 to 24 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) until complete disappearance of the raw material. Upon completion of the reaction, the solvent was removed by evaporation under reduced pressure. The residue was purified by silica gel column chromatography with an eluent ratio of cyclohexane/ethyl acetate (90:10 to 70:30). | | References | [1] Physical Chemistry Chemical Physics, 2015, vol. 17, # 15, p. 10238 - 10249
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 161 - 170
[3] Justus Liebigs Annalen der Chemie, 1907, vol. 357, p. 373
[4] Journal of the American Chemical Society, 1982, vol. 104, # 16, p. 4469 - 4477
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 20, p. 8969 - 8973 |
| | 4-Methoxy-1-naphthaldehyde Preparation Products And Raw materials |
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