藏红花醛
| 中文名称 | 藏红花醛 |
|---|---|
| 中文同义词 | 番紅花醛;藏花醛/藏红花醛;2,3-二氢-2,2,6-三甲基苯甲醛;藏红花醛;藏花醛;2,3-二氢-2,2,6-三甲基苯甲醛(藏花醛,藏红花醛);SAFRANAL (>80%);波斯菊 |
| 英文名称 | SAFRANAL |
| 英文同义词 | 1,1,3-TRIMETHYL-2-FORMYLCYCLOHEXA-2,4-DIENE;Safranal,2,3-Dihydro-2,2,6-trimethylbenzaldehyde;2,6,6-triMethylcyclohexa-1,3-dienecarbaldehyde;Safranal (>80%);2,6,6-Trimethyl-1,3-cyclohexadienal;2,6,6-Trimethyl-1,3-cyclohexadiene-1-carbaldehyde;2,6,6-trimethyl-3-cyclohexadiene-1-carboxaldehyde;3-Cyclohexadiene-1-carboxaldehyde,2,6,6-trimethyl-1 |
| CAS号 | 116-26-7 |
| 分子式 | C10H14O |
| 分子量 | 150.22 |
| EINECS号 | 204-133-7 |
| 相关类别 | 化工材料;香精香料;单体香料;植物提取物 |
| Mol文件 | 116-26-7.mol |
| 结构式 |  |
藏红花醛 性质
| 熔点 | <25 °C |
|---|---|
| 沸点 | 70 °C1 mm Hg(lit.) |
| 密度 | 0.966 g/mL at 25 °C(lit.) |
| 蒸气压 | 10.3Pa at 20℃ |
| FEMA | 3389 | 2,6,6-TRIMETHYLCYCLOHEXA-1,3-DIENYL METHANAL |
| 折射率 | n |
| 闪点 | 186 °F |
| 储存条件 | Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 可溶于氯仿、乙酸乙酯（少许）、甲醇（少许） |
| 形态 | 油状 |
| 颜色 | 黄色至深黄色 |
| 气味 (Odor) | 1.00% 的二丙二醇溶液。酚醛类气味， 烟草味， 辛辣味 |
| 香型 | herbal |
| 生物来源 | synthetic |
| 水溶解性 | 514.9mg/L at 20℃ |
| Merck | 13,8394 |
| JECFA Number | 977 |
| BRN | 1932918 |
| 稳定性 | 感光 |
| 主要应用 | flavors and fragrances |
| 化妆品成分功效 | PERFUMING |
| InChI | 1S/C10H14O/c1-8-5-4-6-10(2,3)9(8)7-11/h4-5,7H,6H2,1-3H3 |
| InChIKey | SGAWOGXMMPSZPB-UHFFFAOYSA-N |
| SMILES | CC1=C(C=O)C(C)(C)CC=C1 |
| LogP | 2.7 at 20℃ |
| EPA化学物质信息 | 1,3-Cyclohexadiene-1-carboxaldehyde, 2,6,6-trimethyl- (116-26-7) |
藏红花醛呈黄色液体状，溶于乙醇等有机溶剂。
藏红花醛可由藏红花中的苦味素一苦藏花素在酸中水解取得，或由β-环柠檬醛或a-环香叶酸用氧化硒催化脱氢制得。
Safranal 是藏红花 (Crocus sativus) 的主要成分，具有口服活性，是这种香料的独特香气来源。Safranal 具有神经保护和抗炎作用，并有用于帕金森氏病的研究潜力。
Safranal (10-50 μM; for 1 h) dose-dependently decreases LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Safranal (10-50 μM; for 1 h) inhibits cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells.
Safranal (10, 50 μM; for 1 h followed by stimulation with 1 μg/ml of LPS for 30 min) inhibits the nuclear translocation of NF-κB and AP-1 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells.
Western Blot Analysis
| Cell Line: | RAW264.7 cells and bone marrow-derived macrophages (BMDMs) |
| Concentration: | 10, 50 μM |
| Incubation Time: | For 1 h prior to lipopolysaccharide (LPS) stimulation (1 µg/ml) |
| Result: |
Dose-dependently decreased LPS-induced iNOS and COX-2 levels in both RAW264.7 cells and BMDMs.
Inhibited the phosphorylation of MAPK pathway proteins extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), p38. Inhibited NF-κB pathway proteins IKKα/β and IκBα and the degradation of IκBα. |
RT-PCR
| Cell Line: | RAW 264.7 cells |
| Concentration: | 10, 50 μM |
| Incubation Time: | For 1 h followed by stimulation with LPS (1 μg/ml) for 24 h |
| Result: | Inhibited cytokine IL-6 and TNF-α production and mRNA expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. |
Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low.
| Animal Model: | Female BALB/c mice (18-20 g) (DSS-induced colitis mice) |
| Dosage: | 200, 500 mg/kg |
| Administration: | PO; for 7 days |
| Result: | Caused a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low. |
安全信息
| 提供商 | 语言 |
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英文
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