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ChemicalBook CAS DataBase List 1-Methoxy-2-propanol

1-Methoxy-2-propanol synthesis

2synthesis methods
1-Methoxy-2-propanol is used as a reagent in the synthesis of 2-amino-3-carboxy-4-phenylthiophenes, which acts as a protein kinase C inhibitors. It is also used as a reagent in the synthesis of metolachlor.
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Yield:-

Reaction Conditions:

with phosphotungstic acid;dihydrogen peroxide in water at 50; under 11251.1 Torr; for 2 h;Molecular sieve;Reagent/catalyst;Temperature;Pressure;

Steps:

1 Test Example 1

Propylene, aqueous hydrogen peroxide,Methanol and catalyst (mass ratio of modified titanium silica molecular sieve to phosphotungstic heteropoly acid H3PW12O40 is 10:1),According to the molar ratio of propylene to hydrogen peroxide and methanol: 1:2:5, the mass ratio of propylene to catalyst is 20:1,The reaction was carried out at a temperature of 50 ° C and a pressure of 1.5 MPa.The results of the reaction for 2 hours are shown in Table 1.

References:

CN108002986,2018,A Location in patent:Paragraph 0117; 0118; 0119; 0120; 0121; 0122; 0123-0130

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