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Propylene glycol

Physical and Chemical Properties Medicinal property and application Content analysis Toxicity Use limitation Chemical property Uses Synthesis method Category Toxicity grading Acute toxicity Irritation data Explosive hazardous characteristics Flammability hazard characteristics Storage characteristics Extinguishing agent
Propylene glycol
Propylene glycol
CAS No.
57-55-6
Chemical Name:
Propylene glycol
Synonyms
PG;PGI;gpi;pg12;gpia;PG 12;ZeMea;PG-AAF;PG-ADF;ucar35
CBNumber:
CB8485612
Molecular Formula:
C3H8O2
Formula Weight:
76.09
MOL File:
57-55-6.mol

Propylene glycol Properties

Melting point:
-60 °C
Boiling point:
187 °C(lit.)
Density 
1.036 g/mL at 25 °C(lit.)
vapor density 
2.62 (vs air)
vapor pressure 
0.08 mm Hg ( 20 °C)
refractive index 
n20/D 1.432(lit.)
FEMA 
2940 | PROPYLENE GLYCOL
Flash point:
225 °F
storage temp. 
Store at RT.
form 
Viscous Liquid
color 
APHA: ≤10
Specific Gravity
1.038 (20/20℃)1.036~1.040
PH
6-8 (100g/l, H2O, 20℃)
explosive limit
2.4-17.4%(V)
Water Solubility 
miscible
Sensitive 
Hygroscopic
Merck 
14,7855
BRN 
1340498
InChIKey
DNIAPMSPPWPWGF-UHFFFAOYSA-N
CAS DataBase Reference
57-55-6(CAS DataBase Reference)
NIST Chemistry Reference
Propylene glycol(57-55-6)
EPA Substance Registry System
1,2-Propanediol(57-55-6)

SAFETY

Safety Statements  24/25
WGK Germany  1
RTECS  TY2000000
Autoignition Temperature 779 °F
TSCA  Yes
HS Code  29053200
Hazardous Substances Data 57-55-6(Hazardous Substances Data)
Toxicity LD50 orally in Rabbit: 19400 - 36000 mg/kg LD50 dermal Rabbit 20800 mg/kg

Propylene glycol price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 12279 1,2-Propanediol analytical standard 57-55-6 1ml-f $21.9 2018-11-13 Buy
Sigma-Aldrich 12279 1,2-Propanediol analytical standard 57-55-6 5ml-f $84.4 2018-11-13 Buy
TCI Chemical P0485 1,2-Propanediol >99.0%(GC) 57-55-6 500g $20 2018-11-22 Buy
Alfa Aesar 030948 1,2-Propanediol, ACS, 99.5% 57-55-6 1L $65.3 2018-11-16 Buy
Alfa Aesar 030948 1,2-Propanediol, ACS, 99.5% 57-55-6 *4x1L $183 2018-11-16 Buy

Propylene glycol Chemical Properties,Uses,Production

Physical and Chemical Properties

Propylene glycol is scientifically named as “1,2-propanediol”, and has a chemical formula of CH3CHOHCH2OH and a molecular weight of 76.10. There is a chiral carbon atom in the molecule. Its racemate is a hygroscopic viscous liquid and is slightly spicy. It has a specific gravity of 1.036 (25/4 °C), a freezing point of-59 °C, and a boiling point of 188.2 °C, respectively 83.2 °C (1,333 Pa). It is miscible with water, acetone, ethyl acetate and chloroform, and is soluble in ether. It is soluble in many essential oils, but is not miscible with petroleum ether and paraffin oil. It is relatively stable to heat and light, and is more stable at low temperatures. Its L-isomer has a boiling point of 187 to 189 °C and a specific optical rotation [α] of D20-15.0°. It can be oxidized at high temperatures to propionaldehyde, lactic acid, pyruvic acid and acetic acid.
 the molecular structure of propylene glycol
Figure 1 the molecular structure of propylene glycol.
Propylene glycol is a diol having the general nature of the alcohol. It can react with inorganic and organic acids to generate mono-or di-esters. It reacts with propylene oxide to generate ether, with hydrogen halide to generate halohydrin, and with acetaldehyde to generate methyl dioxolane.

Medicinal property and application

Propylene glycol has good solubility and less toxicity and irritation, and is widely used as solvents, extraction solvents and preservatives for injections (eg. intramuscular injections, intravenous injections) and non-injectable pharmaceutical preparations (such as oral liquid, ophthalmic preparations, otic preparations, dental preparations, rectovaginal preparations, transdermal preparations, etc.). It is better than glycerol solvent and can dissolve many substances such as corticosteroids (sex hormone), chloramphenicol, sulfonamides, barbiturate, reserpine, quinidine, corticosterone acetate, tetrahydropalmatine sulfate, mechlorethamine hydrochloride, vitamin A, vitamin D, many volatile oils, most of the alkaloids and many local anesthetics.
Propylene glycol is similar to ethanol when used as a bacteriostatic agent, and its efficacy to inhibit mold is similar to glycerin and is slightly lower than that of ethanol. Propylene glycol is commonly used as a plasticizer for the aqueous film coating materials. Its mixture with equal amounts of water can delay the hydrolysis of certain drugs, and increase the stability of the preparation product. It is used as an antimicrobial preservative in 15% to 30% propylene glycol solution and semi-solid formulation, as humectants in about 15% propylene glycol topical formulation, and as solvent and co-solvent in 10% to 30% propylene glycol aerosol solvent, 10% to 25 % propylene glycol oral solution, 10% to 60% injectable formulation and 5% to 80% topical formulation.
[Stability and storage condition] It is very stable at room temperature, but is oxidized when left open at high temperatures (above 280 °C); has a chemical stability after mixing with 95% ethanol or water; can be sterilized by autoclaving or sterile filtration. Propylene glycol has hygroscopicity, and should be positioned at cool and dry place and stored in dark airtight container.
[Incompatibility] It has incompatibility with some oxidants (such as potassium permanganate).
The above information is edited by the Chemicalbook of Jin Yinxue.

Content analysis

A 10μl sample is injected into the gas chromatograph, which has a thermal conductivity detector. The column is 1m × 6.35mm stainless steel column. The filler is polyethylene glycol 20M (Carbowax compound 20M) 4%, and the carrier is a 40/60 mesh sieved polytetrafluoroethylene (Chromosorb T) or similar material. Helium carrier gas has a flow rate of 75ml/min. Injector temperature is 240 °C; column temperature is 120 to 200 °C, temperature increment is 5 °C/min; final temperature is 250 °C. Under specified conditions, the residence time of propylene glycol is about 5.7 minutes, the residence time of three kinds of glycol isomers are respectively 8.2, 9.0 and 10.2 minutes. The area of each peak is determined using any proper method, and then the percentage of propylene glycol area is calculated and transformed into mass percentage.

Toxicity

FAO/WHO (2000): ADI is 0 to 25mg/kg.
LD50 is 22 to 23.9 mg/kg (mouse, oral).
GRAS (FDA, §184.1666, 2000).

Use limitation

FAO/WHO (1984): Cottage cheese, the cream mixture amount of 5g/kg (used alone or in combination with other carriers and stabilizers).
Japan (1998): Raw noodles, raw stuffing and cuttlefish smoked products ≤2%; skins for dumplings, steamed dumplings, spring rolls and wonton ≤1.2%; other food ≤0.6%.
GB 2760-96: pastry 3.0g/kg, chewing gum.
FDA, §184.1666 (2000): Alcoholic beverages 5%; frosting and candy 24%; frozen dairy 2.5%; flavoring agents, flavor enhancers 97%; nuts and nut products 5%; other food 2.0%.

Chemical property

It is a colorless, stable and viscous hydroscopic liquid, and is almost odorless and tasteless. It is miscible with water, ethanol and various organic solvents.

Uses

1. It is used as a resin, a plasticizer, a surfactant, and materials for emulsifier and demulsifier. It is also used as antifreeze and heat carrier.
2. It is used as gas chromatography stationary phase, solvents, antifreeze, a plasticizer and a dehydrating agent.
3. A carrier solvent; wetting agents; moisturizing agents; anti-caking agents; antioxidants; texturizing agents; surfactant; stabilizer; a thickener; dough modifiers; emulsifiers; flavoring agents; excipient; processing aids.GB2760-96 lists it as food processing aids.
It is mainly used as solvents for a variety of flavors, colors and preservatives, and as extraction solvents for vanilla beans, roasted coffee grains and natural spices. It is used as moisturizing agents and softeners for candy, bread, packaged meats and cheese. It is also used as mildew agents for noodles and sandwiches class. Addition of 0.006% in soymilk enables the flavor not to change upon heating and produces white glossy packaging tofu, which undergoes volume expansion when fried.
4. Propylene glycol is an intermediate for fungicide difenoconazole.
5. It is used a solvent. Preservatives, colorings, antioxidants and other poorly water-soluble food additives can be dissolved therein, which is then added into food; it is strongly hygroscopic and has food moisturizing and anti-freeze effect. China stipulates its use for pastry, and the maximum usage is 3.0g/kg.
6. Propylene glycol is an important raw material for unsaturated polyester, epoxy resin, and polyurethane resin. The use amount in this area accounts for about 45% of the total consumption of propylene glycol. Such unsaturated polyester is used extensively for reinforced plastics and surface coatings. Propylene glycol is excellent in viscosity and hygroscopicity and is non-toxic, and thus is widely used as hygroscopic agent, antifreeze, lubricants and solvents in the food, pharmaceutical and cosmetic industry. In the food industry, propylene glycol reacts with fatty acid to give propylene ester of fatty acids, and is mainly used as food emulsifier; Propylene glycol is a good solvent for flavorings and pigments. Propylene glycol is commonly used as solvents, softeners and excipients, etc. in the pharmaceutical industry for the manufacture of various types of ointments and salves. Propylene glycol is also used as a solvent and a softener for cosmetic since it has good mutual solubility with various spices. Propylene glycol is also used as tobacco moisturizing agents, antifungal agents, food processing equipment lubricants and solvents for food marking ink. Aqueous solution of propylene glycol is an effective anti-freeze agent.
7. It is used as a drug carrier, and agents for drug particles. It can be used as humectants, softeners, solvents and the like in cosmetics. It can be used as tobacco flavor, tobacco moisturizing agents, preservatives and the like in the tobacco industry. It can be used as flavor, food coloring solvents, food packaging softeners, food release agent and the like in food industry. It can also be used for the production of unsaturated polyester resins, and is also raw materials for plasticizers, dehydrating agents, surfactants, curing agents and binders. It can also be used in paints, pesticides, coatings and other industries.
8. It is used in aviation de-icing fluid, refrigerant and antifreeze, food and spices, fragrances, cosmetics and personal care products, heat transfer fluids, hydraulic and brake fluids, paints and coatings, pet food/animal feeding stuffs, medicines, polyurethane, unsaturated polyester resin and the like.

Synthesis method

It can be obtained by hydrolysis of Propylene oxide:
CH3CHCH2+H2O[H+]→CH3CH(OH)CH2OH
Direct hydration
Propylene oxide and water are fed in a molar ratio of 1: 15, and react at 150-2000 °C, a pressure of 1.2-1.4 MPa for 30 minutes to obtain 16% aqueous solution of propylene glycol, which is subjected to evaporation to obtain the finished product.
Catalyzed hydrolysis
The reaction is performed under catalyzation of sulfuric acid or hydrochloric acid. 0.5% to 1.0% dilute sulfuric acid is added into 10% to 15% aqueous solution of propylene oxide, the mixture is hydrolyzed at 50 to 70 °C; the hydrolysate is neutralized and concentrated under reduced pressure, and refined to obtain the finished products.
The preparation method is a method in which propylene oxide is hydrolyzed to propylene glycol, and which can be carried out in the liquid phase. There are catalytic and non-catalytic processes in industry. Catalytic method is a method in which hydrolysis is carried out in the presence of 0.5% to 1% sulfuric acid at 50 to 70 °C. Non-catalytic process is carried out under high temperature and pressure (150 to 300℃, 980 to 2940kPa), and is used for production in domestic.

Category

flammable liquid

Toxicity grading

low toxicity

Acute toxicity

Oral-rat LD50: 20000 mg/kg; Oral-Mouse LD50: 32000 mg/kg

Irritation data

Eyes-rabbit 100 mg mild

Explosive hazardous characteristics

explosive when mixed with air

Flammability hazard characteristics

Flammable; generate irritating smoke upon combustion

Chemical Properties

clear viscous liquid

Chemical Properties

Propylene glycol is a colorless, odorless, syrupy liquid.

Uses

Next to water, propylene glycol is the most common moisturecarrying vehicle used in cosmetic formulations. It has better skin permeation than glycerin, and it also gives a pleasant feel with less greasiness than glycerin. Propylene glycol is used as a humectant because it absorbs water from the air. It also serves as a solvent for anti-oxidants and preservatives. In addition, it has preservative properties against bacteria and fungi when used in concentrations of 16 percent or higher. There is a concern that propylene glycol is an irritant at high concentrations, though it appears to be quite safe at usage levels under 5 percent.

Uses

Propylene Glycol is a humectant and flavor solvent that is a polyhy- dric alcohol (polyol). it is a clear, viscous liquid with complete solu- bility in water at 20°c and good oil solvency. it functions as a humectant, as do glycerol and sorbitol, in maintaining the desired moisture content and texture in foods such as shredded coconut and icings. it functions as a solvent for flavors and colors that are insoluble in water. it is also used in beverages and candy.

Uses

Used as a solvent.

Definition

An alcohol in which the hydroxyl groups are attached to a carbon atom of a branched or straight-chain aliphatic hydrocarbon.

brand name

Sentry Propylene Glycol (Union Carbide); Sirlene (Dow Chemical).

Storage characteristics

Ventilated warehouse and low-temperature drying.

Extinguishing agent

Dry powder, foam, sand, water.

General Description

Thick odorless colorless liquid. Mixes with water.

Air & Water Reactions

Water soluble.

Reactivity Profile

1,2-Propanediol is hygroscopic. 1,2-Propanediol is sensitive to excessive heat (tends to oxidize at high temperatures). 1,2-Propanediol can react with oxidizing materials. 1,2-Propanediol is incompatible with acid chlorides, acid anhydrides, chloroformates, and reducing agents. 1,2-Propanediol dissolves many essential oils. A mixture of 1,2-Propanediol with hydrofluoric acid and silver nitrate was put in a glass bottle which burst 30 minutes later.

Hazard

Toxic.

Health Hazard

Liquid may irritate eyes.

Fire Hazard

1,2-Propanediol is combustible.

Contact allergens

Propylene glycol is used as a solvent, a vehicle for topical medicaments such as corticosteroids or aciclovir, an emulsifier and humectant in food and cosmetics, and as antifreeze in breweries, in the manufactures of resins. It was present as an occupational sensitizer in the color film developer Flexicolor?. Patch tests in aqua are sometimes irritant.

Safety Profile

Slightly toxic by ingestion, skin contact, intraperitoneal, intravenous, subcutaneous, and intramuscular routes. Human systemic effects by ingestion: general anesthesia, convulsions, changes in surface EEG. Experimental teratogenic and reproductive effects. An eye and human skin irritant. Mutation data reported. Combustible liquid when exposed to heat or flame; can react with oxidizing materials. Explosive in the form of vapor when exposed to heat or flame. May react with hydrofluoric acid + nitric acid + silver nitrate to form the explosive silver fulminate. To fight fire, use alcohol foam. When heated to decomposition it emits acrid smoke and irritating fumes.

Potential Exposure

Propylene glycol is used as a solvent; emulsifying agent; food and feed additive; flavor, in manu- facture of plastics; as a plasticizer, surface-active agent; antifreeze, solvent, disinfectant, hydroscopic agent; coolant in refrigeration systems; pharmaceutical, brake fluid; and many others.

First aid

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, includ- ing resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medi- cal attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.

Purification Methods

Dry the diol with Na2SO4, decant and distil it under reduced pressure. [Beilstein 1 IV 2468.]

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explo- sions. Keep away from alkaline materials, strong acids (especially nitric acid), strong bases, permanganates, dichromates; may cause a violent reaction.

Waste Disposal

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.All federal, state, and local environmental regulations must be observed.

Propylene glycol Preparation Products And Raw materials

Raw materials

Preparation Products


Propylene glycol Suppliers

Global( 515)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hefei TNJ Chemical Industry Co.,Ltd.
86-0551-65418684 18949823763
86-0551-65418684 info@tnjchem.com China 1659 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32651 55
Hebei Guanlang Biotechnology Co., Ltd.
+86-0311-66562153 whatsapp +8615203118427
+86-0311-66562153 sales@crovellbio.com CHINA 416 50
Shenzhen Sendi Biotechnology Co.Ltd.
0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3217 55
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 22049 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20786 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555
+86-021-57951555 jack.li@time-chemicals.com CHINA 1374 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 663 60
Jiangsu Qingquan Chemical Co., Ltd.
+86-571-86589381/86589382/86589383
lyy@qqpharm.com sales1@qqpharm.com CHINA 177 55
Tianjin Zhongxin Chemtech Co., Ltd.
022-89880739
022-66880086 sales@tjzxchem.com CHINA 559 58

View Lastest Price from Propylene glycol manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-01-21 1,2-PROPYLENE GLYCOL
57-55-6
US $10.00 / Kg 1Kg 99% 10000kg/kg hebei chisure biotechnology co.,ltd
2019-01-02 Propylene Glycol cas 57-55-6 (whatsapp:+8618830163278)
57-55-6
US $15.00 / kg 1kg 99.8% 19tons Hebei Huanhao Biotechnology Co., Ltd.
2018-12-17 Propylene glycol
57-55-6
US $1.00 / kg 1kg 99% 100KG career henan chemical co

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