2-(2-Chlorophenyl)-4,5-diphenylimidazole synthesis
- Product Name:2-(2-Chlorophenyl)-4,5-diphenylimidazole
- CAS Number:1707-67-1
- Molecular formula:C21H15ClN2
- Molecular Weight:330.81
89-98-5
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$18.00/25g
134-81-6
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57-13-6
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$5.00/5g
1707-67-1
105 suppliers
$31.00/5g
Yield: 76%
Reaction Conditions:
with ammonium acetate;zinc(II) chloride at 70 - 110; for 0.5 h;Green chemistry;
Steps:
Imidazoles 3a-y; General Procedure
General procedure: 0.8 g of urea/zinc chloride DES (3.5:1) was heated to 70 °C to obtain a clear melt. To this melt a mixture of dicarbonyl compound (1 mmol), aldehyde (1 mmol) and ammonium acetate (2mmol) was added and the reaction was stirred at 110 °C for 30 minutes. After completion of the reaction (monitored by TLC), the reaction mixture was quenched by adding water while still hot, cooled to room temperature and the crude solid was filtered, washed with water and ethanol (3 x 2 mL) to afford the pure product.
References:
Higuera, Natalia López;Peña-Solórzano, Diana;Ochoa-Puentes, Cristian [Synlett,2019,vol. 30,# 2,p. 225 - 229] Location in patent:supporting information
631-61-8
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89-98-5
666 suppliers
$18.00/25g
119-53-9
410 suppliers
$5.00/25g
1707-67-1
105 suppliers
$31.00/5g