ChemicalBook CAS DataBase List 2,2'-Dihydroxy-4,4'-dimethoxybenzophenone

2,2'-Dihydroxy-4,4'-dimethoxybenzophenone synthesis

9synthesis methods

Product Name:2,2'-Dihydroxy-4,4'-dimethoxybenzophenone
CAS Number:131-54-4
Molecular formula:C15H14O5
Molecular Weight:274.27

preparation by reaction of 2-hydroxy-4-methoxy-benzoic acid with resorcinol monomethyl ether in the presence of zinc chloride and phosphorous oxychloride at 7075° for 2.

131-55-5 Synthesis

131-55-5
427 suppliers
$10.00/5g

77-78-1
287 suppliers
$22.00/25g

2,2'-Dihydroxy-4,4'-dimethoxybenzophenone

131-54-4
312 suppliers
$12.00/5g

Yield:131-54-4 130 kg

Reaction Conditions:

with zinc(II) chloride in ethanol;1,2-dichloro-ethane at 45 - 50; for 8 h;Industrial scale;

Steps:

1.1

methylation reaction: To the reaction kettle was charged 123 kg of 2, 2 ', 4,4'-tetrahydroxybenzophenone, 2.95 kg of zinc chloride and 590 L of mixed solvent prepared from 295 L of dichloroethane and 295 L of anhydrous ethanol, Dissolved, heated to 45 ~ 50 ° C, dropping dimethyl sulfate 148kg, 2h drop is completed, Insulation reaction 6h; Cooling to room temperature, add water 148L stirring dissolved, and then standing stratification, separation of the organic phase, the aqueous phase extracted with dichloroethane twice, each amount of 50L, combine the organic phase, distillation recovery solvent, cooling crystallization, , 2'-dihydroxy-4,4'-dimethoxybenzophenone (about 130kg) and the yield of 95% (calculated as 2,2',4,4'-tetrahydroxybenzophenone)

References:

CN104262209,2016,B Location in patent:Paragraph 0006; 0025; 0026

673-22-3 Synthesis