Salicylaldehyde synthesis
- Product Name:Salicylaldehyde
- CAS Number:90-02-8
- Molecular formula:C7H6O2
- Molecular Weight:122.12
84761-77-3
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90-02-8
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Yield:90-02-8 100%
Reaction Conditions:
with caesium carbonate in toluene at 80; for 15 h;Sealed tube;Reagent/catalyst;Solvent;Temperature;
Steps:
General procedure for deprotection of triflates
General procedure: Toa solution of aryl triflate 1a-k (0.3 mmol) in distilledtoluene (5 mL) was added Cs2CO3(3 eq.). The suspension was heated at 80 °C (oilbath temp) during 15h. The crude mixture was quenched withethyl acetate (~5 mL) and a saturatedaqueous solution of ammonium chloride (~10 mL).The aqueous layer was extracted with ethyl acetate (2x10 mL). Organic layerswere then combined, dried over MgSO4 and concentratedunder reduced pressure to afford the corresponding phenol 2a-k that was purified byflash chromatography over silica gel.
References:
Green, Alice E.;Agouridas, Vangelis;Deniau, Eric [Tetrahedron Letters,2013,vol. 54,# 51,p. 7078 - 7079] Location in patent:supporting information
40138-16-7
341 suppliers
$9.00/1g
90-02-8
438 suppliers
$9.00/1g
