ChemicalBook CAS DataBase List 2,4'-Difluorobenzophenone

2,4'-Difluorobenzophenone synthesis

6synthesis methods

Product Name:2,4'-Difluorobenzophenone
CAS Number:342-25-6
Molecular formula:C13H8F2O
Molecular Weight:218.2

1765-93-1 Synthesis

1765-93-1
543 suppliers
$9.00/1g

446-52-6 Synthesis

446-52-6
425 suppliers
$6.00/25g

342-25-6
290 suppliers
$6.00/5g

Yield:342-25-6 98%

Reaction Conditions:

with potassium phosphate;palladium diacetate in water;methyl cyclohexane; for 8 h;Reflux;Solvent;

Steps:

3 Example 3

Method of the present embodiment provides a 2,4 ′-difluorobenzophenone and preparation method thereof, as follows: in a 1000 ml round bottom flask The bottle was added sequentially o-fluoro benzaldehyde 124 g of 4-fluorophenylboronic acid and 140 g of potassium phosphate, 106 grams, 1.12 g of palladium acetate, then adding 500 ml of methyl cyclohexane and 100 ml of water and heated to reflux for 8 hours., sequentially passes through filtering, layering, washing with water, removing the solvent to obtain the product., 2,4 '-difluorobenzophenone 214 g, 98% yield.

References:

CN104230691,2016,B Location in patent:Paragraph 0028-0029