2',6'-Dimethoxyacetophenone synthesis
- Product Name:2',6'-Dimethoxyacetophenone
- CAS Number:2040-04-2
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield:2040-04-2 84%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 16 h;
Steps:
6 Example 6 (S)-N-(2-cyano-1-(1-hydroxy-7-isopropyl-1,3-dihydrobenzo[c][1,2]oxaborol-6-yloxy)propan-2-yl)-4-(trifluoromethoxy)benzamide
Example 6 (S)-N-(2-cymo- 1 -( 1 -hydroxy-7-isopropyl- 1 ,3 -dihydrobenzo [c] [ 1 ,2"|oxaborol-6-yloxy")pro pan-2-yl')-4-('trifluoromethoxy')benzamide To a solution of l-(2,6-dihydroxyphenyl)ethanone (50.0g, 329.0mmol) and potassium carbonate (136.2g, 986.8mmol) in DMF (200mL) is added CH3I (48.6mL, 822.5mmol) slowly at rt. The mixture is stirred for 16h at rt, poured into ice water (lOOOmL) and stirred for 30 min. The precipitate is filtered, washed with water and dried to give the desired product as a light yellow solid (50g, yield 84%).
References:
ELI LILLY AND COMPANY;ANACOR PHARMACEUTICALS INC.;AKAMA, Tsutomu;JARNAGIN, Kurt;PLATTNER, Jacob J.;PULLEY, Shon Roland;WHITE, William Hunter;ZHANG, Yong-Kang;ZHOU, Yasheen WO2014/149793, 2014, A1 Location in patent:Page/Page column 51
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