2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane synthesis
- Product Name:2-Methoxy-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
- CAS Number:1195-66-0
- Molecular formula:C7H15BO3
- Molecular Weight:158
76-09-5
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121-43-7
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$13.00/25mL
1195-66-0
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$5.00/1g
Yield:1195-66-0 90%
Reaction Conditions:
for 6 h;Inert atmosphere;Reflux;
Steps:
Synthesis of 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane
Synthesis of 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane A flask equipped with a reflux condenser, stirrer, an inert gas inlet and a thermocouple set in heating mantle was charged with trimethyl borate and pinacol under positive pressure of nitrogen. The resulting mixture was heated at reflux for 6 hours. The mixture was cooled to ambient temperatures and transferred to a flask with a Vigreux column. The mixture was distilled at atmospheric pressure to afford 2-methoxy-4,4,5,5-tetramethyl[1,3,2]dioxaborolane (bp 159° C.) in high yield (90%). 1H NMR (400 MHz, CDCl3): δ 3.41 (m, 3H), 1.11 (m, 12H). 11B NMR (128.3 MHz, CDCl3): δ 22.2. 13C NMR (100.6 MHz, CDCl3): δ 82.7, 52.6, 24.6.
References:
Anderson Development Company US2012/289733, 2012, A1 Location in patent:Page/Page column 4
124-38-9
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25015-63-8
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1195-66-0
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616-38-6
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1195-66-0
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124-38-9
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25015-63-8
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1195-66-0
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67-56-1
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73183-34-3
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1195-66-0
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1333-74-0
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