ChemicalBook CAS DataBase List 3',5'-Dichloroacetophenone

3',5'-Dichloroacetophenone synthesis

9synthesis methods

Product Name:3',5'-Dichloroacetophenone
CAS Number:14401-72-0
Molecular formula:C8H6Cl2O
Molecular Weight:189.04

3032-81-3

108-24-7

14401-72-0

General procedure for the synthesis of 1-(3,5-dichlorophenyl)ethanone from 3,5-dichloroiodobenzene (37.0 g, 136 mmol) and acetic anhydride: 3,5-dichloroiodobenzene, Pd2(dba)3 (1.5 g, 1.6 mmol), and lithium chloride (29.0 g, 682 mmol) were dissolved in 100 ml of DMF in a 500 ml round bottomed flask. Subsequently 64.0 ml of acetic anhydride and 47.0 ml of N-ethyl diisopropylamine were added to the reaction mixture. The reaction mixture was heated at 100°C for the reaction. After completion of the reaction, water was added to the mixture, extracted with ethyl acetate and the product was purified by column chromatography using ethyl acetate as eluent. 8 g of 1-(3,5-dichlorophenyl)ethanone was finally obtained.

3032-81-3
215 suppliers
$10.00/1g

108-24-7
0 suppliers
$14.00/250ML

14401-72-0
147 suppliers
$9.00/1g

Yield: 8 g

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;N-ethyl-N,N-diisopropylamine;lithium chloride in N,N-dimethyl-formamide at 100; for 8 h;

Steps:

4.1
Dichloroiodobenzene(37. 0g, 136mmol), Pd ₂ (dba) ₃ (1. 5g, 1. 6mmol), lithium chloride (29. 0g, 682mmol) to, dissolved in 100 ml of DMF in 500 ml of a round bottom flask. 64. 0 ml of acetic anhydride and 47. 0 ml of N-ethyl diisopropylamide are then added to the reaction mixture. 8 100 °C the reaction product is heated. Water is added to the reaction mixture, product is extracted with ethyl acetate, ethyl acetate and eluent Phenylbicyclohexane using a immunochromatography glycopeptide is used. Obtd. 8g of the product.

References:

UNIVERSAL DISPLAY CORPORATION;ALLEYNE, BERT;KWONG, RAYMOND;YEAGER, WALTER;XIA, CHUANJUN JP2015/212297, 2015, A Location in patent:Paragraph 0106; 0107

6575-00-4 Synthesis