3H-IMidazo[4,5-b]pyridine-6-carbonitrile synthesis
- Product Name:3H-IMidazo[4,5-b]pyridine-6-carbonitrile
- CAS Number:773884-58-5
- Molecular formula:C7H4N4
- Molecular Weight:144.13
107238-27-7
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Yield:773884-58-5 91%
Reaction Conditions:
at 100; for 2 h;
Steps:
10.C; 30.C Step C: Preparation of 3H-imidazo[4,5-b]pyridine-6-carbonitrile:
To a solution of 5,6- diaminopyridine-3-carbonitrile (7.0 g, 52.2 mmol) in triethyl orthoformate (100 mL) was added formic acid (6.3 mL, 52.2 mmol) slowly at ambient temperature. After addition, the reaction mixture was stirred at 100 °C for 2 hours. After cooling to ambient temperature, the mixture was concentrated under reduced pressure. The residue was purified by recrystallization from ethyl acetate to give 3H-imidazo[4,5-b]pyridine-6-carbonitrile (6.9 g, 91%) as a solid. ESI (+) m/z 145 (M+H).
References:
WO2019/232319,2019,A1 Location in patent:Paragraph 0359; 0532
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