ChemicalBook CAS DataBase List 4-Nitrophenylboronic acid pinacol ester

4-Nitrophenylboronic acid pinacol ester synthesis

14synthesis methods

Product Name:4-Nitrophenylboronic acid pinacol ester
CAS Number:171364-83-3
Molecular formula:C12H16BNO4
Molecular Weight:249.07

98-74-8
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$10.00/5g

73183-34-3
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171364-83-3
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$7.00/250mg

Yield: 78%

Reaction Conditions:

with dipotassium hydrogenphosphate in acetonitrile at 20; for 24 h;UV-irradiation;

Steps:

4 Synthesis of 4-nitrophenylboronic acid ester
To a 25 mL reaction tube was added 2 mL of acetonitrile, 4-methylbenzenesulfonyl chloride (66.3 mg, 0.3 mmol), boronic acid pinacol ester (114.3 mg, 0.45 mmol), dipotassium hydrogen phosphate (104.4 mg, 2.0 eq.) , And the reaction tube was irradiated with an ultraviolet lamp, and the reaction was carried out by stirring at room temperature for 24 hours.After the reaction was completed, most of the solvent was distilled off under reduced pressure, and the remaining mixture was purified by column chromatography on petroleum ether / ethyl acetate (10: 1) as eluent to obtain the desired product as a yellow solid , 58.3 mg, yield 78%.

References:

Lishui University;YAN, GUO BING;YU, JIAN CN105859761, 2016, A Location in patent:Paragraph 0029-0031